painless mass
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2021 ◽  
Vol 148 (12) ◽  
pp. 102-107
Author(s):  
Trinh Le Huy ◽  
Tran Dinh Anh

Primary breast diffuse large B-cell lymphoma (DLBCL) is a rare non-Hodgkin’s lymphoma with limited data. We here report a case of primary breast diffuse large B-cell lymphoma mimicking breast cancer. A 52-year-old woman had a painless mass in her right breast. Fine needle aspiration cytology and core biopsy were performed which suggested malignant features but could not confirm the specific subtype. Excisional biopsy then was conducted revealing non-Hodgkin lymphoma, which was subsequently confirmed with histopathology and diagnosed as diffuse large B-cell lymphoma (DLBCL). A chest computed tomography scan revealed a 3.5 cm sized breast mass with skin thickening and modest lymphadenopathy in the ipsilateral axilla. The patient received six courses of R-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone plus rituximab) chemotherapy, then whole breast radiation (30Gy in 15 fractions). At 12 months of follow-up, the patient survives with no evidence of disease. No morbidities occurred in this patient during the follow-up period. We briefly review the current practice pattern in patients with primary breast diffuse large B-cell lymphoma.


2021 ◽  
Vol 49 (12) ◽  
pp. 030006052110643
Author(s):  
Cheng Han Lin ◽  
Karl Wu

Nora’s lesion, also known as bizarre parosteal osteochondromatous proliferation (BPOP), is a very rare benign lesion with few published cases. BPOP is more common in adults during the second to third decades of life, and usually occurs on the hands and feet. Radiologically, it appears as a calcified mass attached to the bone cortex that grows rapidly and that recurs easily following resection. Aggressive features on imaging and confusing histopathological findings usually result in misdiagnosis or mistreatment. Herein, we present a case of a rare bony tumour involving the distal ulna presenting as a painless growing mass. An excisional biopsy with clear margins was performed without disturbing the ulnar nerve and arteries. There was no recurrent mass or calcified lesion 1 year after surgery. Based on its rarity and difficult diagnosis, BPOP should be considered in the differential diagnosis of a painless mass in the distal ulnar region. Careful follow-up after surgery is essential, even without lesion recurrence.


2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Miyako Hoshino ◽  
Katsuyuki Inoue ◽  
Tomohisa Kaneda ◽  
Michiko Nishimura ◽  
Kaoru Kusama ◽  
...  

Clear cell carcinoma (CCC) is a rare entity in the salivary gland tumor. So far, only 10 cases of primary CCC of the buccal mucosa have been reported. Here, we first report an extremely rare case of buccal CCC with the EWSR1-CREM fusion gene. The patient, a 69-year-old woman, presented with a painless mass in the right buccal mucosa. The tumor, which had been present for about 10 years, measured approximately 15 mm in diameter and was pedunculated, elastic hard, smooth, and mobile. Histopathological examination revealed proliferating tumor cells with vacuolated and clear cytoplasm partially surrounded by hyalinized stroma. The tumor was not encapsulated, and no contact with the overlying epithelium was evident. Duct-like structures were occasionally observed in the tumor nests composed of clear cells. The tumor had invaded into surrounding muscle and adipose tissues. Immunohistochemical examination revealed that the clear cells were positive for epithelial cell markers, and myoepithelial markers were negative. Fluorescence in situ hybridization (FISH), performed to search for genetic abnormalities, demonstrated split positivity for EWSR1, and fusion with CREM was confirmed. These findings suggested a diagnosis of CCC.


Author(s):  
Jin Soo Kim ◽  
Jung Hyun Park ◽  
Hee Jeong Lee ◽  
Byung Jun Kim ◽  
Sung Hoon Koh ◽  
...  

Malignant nodular hidradenoma (MNH) is an infrequent, highly malignant tumor derived from eccrine sweat glands. MNH usually occurs on the scalp, trunk, and proximal extremities, and rarely on the hand. A 55-year-old male patient visited clinics with a gradually enlarging painless mass at fingertip. It begins a year ago. Recently, it has grown rapidly and starts ulceration, and bleeding over the past 3 weeks. According to the biopsy report, it has focal necrosis, atypia, atypical mitoses, and nuclear pleomorphism suggested that the mass was MNH. After histological diagnosis, tiny bone erosion was observed in the re-read radiographic finding. For the oncologic evaluation, the patient was transferred to the cancer center. Radical amputation was performed to the residual tumor that might remain based on re-reading of radiographs. MNH of the finger is especially difficult to the diagnosis given its rarity and variable histology. When ulcerative skin lesion and radiographic bone erosion are observed, one should suspect malignancy and makes out a proper therapeutic plan after histologic biopsy.


2021 ◽  
Author(s):  
Chujie Bai ◽  
Lu Zhang ◽  
Yaohui Wang ◽  
Taiyan Guo ◽  
Xia You ◽  
...  

Abstract Undifferentiated high-grade pleomorphic sarcoma (UPS) is a rare soft tissue sarcoma (STS) of mesenchymal origin, particularly the extremities and retroperitoneum, meanwhile it has been reported in almost all parts of the body. UPS is highly invasive and has a poor prognosis due to its clinical manifestations of painless mass and deep tumor site, which are usually found at an advanced stage. Patients with UPS tend to have a lower 5-year survival rate than patients with other types of STS. Recently, NTRK fusions were detected in many cancer types, such as thyroid cancer, colorectal cancer, non-small cell lung cancer, soft tissue tumors, uterine sarcomas, and melanomas. However, the mutation frequency of NTRK fusion in all cancers is only 0.1-1%. Targeted therapy with NTRK inhibitors, such as Larotrectinib and Entrectinib, leads to a response in most patients with NTRK1/2/3 gene fusion-positive tumors. Herein, we present a 68-years old man diagnosed with stage IIIA (T2N0M0G3) UPS. Next-generation sequencing (NGS) revealed a novel TMTC2-NTRK3 fusion. The NTRK3 positivity was also detected by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). He had a response to Larotrectinib. This report broadens the spectrum of NTRK fusions in UPS and highlights a new target for treatment.


2021 ◽  
Author(s):  
Yuan-yuan Liu ◽  
Zhi-hua Zhou ◽  
Shuai Hu ◽  
Xin Su ◽  
jinxu zhou

Abstract Background: This article presents a rare case of skull metastasis of primary hepatocellular carcinoma that manifests the isolated progressive enlargement of the head mass as the first symptom. Case presentation:A 65-year-old female patient presented an isolated painless mass in the head, which grew rapidly over the last month. Head CT revealed a 6.4 cm×5.6cm osteolytic destruction in the right parietal bone. MRI further revealed that the occupation was significantly enhanced in the T1 reinforced phase. The patient underwent total surgical resection. Postoperative pathology confirmed that the head mass was the skull metastasis from hepatocellular carcinoma (HCC). Conclusion: The case of skull metastasis from primary hepatocellular carcinoma is rare, and HCC patient with intracranial metastasis tends to have a rather poor prognosis. Surgical excision of the metastatic mass and radiotherapy can improve the life quality and prolong the survival time of the patient.


BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Margaret K. Gannon ◽  
Amy M. Pearlman

Abstract Background Collagenase Clostridium histolyticum (CCH), also know as Xiaflex, with penile modeling is considered to be the gold standard non-surgical option for management of Peyronie’s disease and is known to be safe and efficacious. Corporal rupture is a rare but known adverse event of CCH treatment, however there are limited studies describing corporal herniation without rupture. Here we present a patient who experienced a rare complication following CCH injections for Peyronie’s disease: lateral herniation of the tunica albuginea in the setting of a dorsal penile plaque. Case presentation A 58-year-old male presented to our clinic seeking treatment for Peyronie’s disease. On exam, he was found to have a palpable dorsal plaque and > 30 degrees leftward curvature of the penis. He was deemed an appropriate candidate for and patient decided to proceed with CCH and modeling. He received 2 cycles of CCH injections (4 total CCH injections) with in-office and at-home penile modeling, per manufacturer’s protocol. Two weeks following in-office modeling during his second CCH cycle, the patient reported a painless, soft swelling involving the left side of his penile shaft only occurring with erection. Exam and history were suggestive of lateral herniation rather than corporal rupture. CCH was discontinued. Patient declined further evaluation with penile ultrasound. Conclusions This is the first case report detailing lateral herniation with CCH injections. Symptoms and exam that should raise suspicion of corporal herniation are a soft, painless mass with erection.


2021 ◽  
Author(s):  
Kaiping Zhang ◽  
Ye Zhang ◽  
Yin Zhang ◽  
Min Chao

Abstract Background: Testicular hemangioma is a extremely rare and typically occurs in childhood or adolescence. It is a benign tumor that appears as a slowly growing painless mass.Case presentation: We herein present the case of a 3 year-old male patient with testicular hemangioma accompanying hydrocele, who underwent surgical resection.Conclusions: This article discusses the diagnosis and currently available treatment options of testicular hemangioma. It also can be provide clinical experiences for urologist in face of similar situation.


2021 ◽  
Vol 1 (25) ◽  
Author(s):  
Xuemiao Zhao ◽  
Xinmu Zhou ◽  
Xiao Chen ◽  
Junqiao Pan ◽  
Bingrong Li

BACKGROUND To the best of the authors’ knowledge, this is the first case of microcystic/reticular schwannoma arising in the frontal bone. OBSERVATIONS An 18-year-old man presented to the authors’ orthopedic clinic with a complaint of a progressively enlarging, painless mass in the frontal bone. It showed significant hyperintensity on T2-weighted imaging with progressive enhancement. Computed tomography combined with three-dimensional reconstruction showed expansive bone destruction with a soft tissue mass in the left side of the frontal bone, without calcification inside or a sclerotic margin around it. The mass was a microcystic/reticular schwannoma as confirmed by surgical pathology. LESSONS The authors report a rare case of a microcystic/reticular schwannoma arising in the frontal bone, with relatively comprehensive imaging data that enabled them to learn more about this tumor.


2021 ◽  
Vol 3 (3) ◽  
pp. 96-99
Author(s):  
O. Oulghoul ◽  
F. Hadid ◽  
O. Benhoummad ◽  
Y. Rochdi ◽  
A. Raji

Introduction: Cystic lymphangioma or cystic hygroma is a congenital malformation of the lymphatic system that manifests as a soft, benign, and painless mass. It originates from remnants of embryonic lymphatic tissue that retains the potential for proliferation. Material and methods: Our retrospective study involved 16 cases of cystic lymphangioma managed between 2017 and 2020. Results: This study included 9 girls and 7 boys with a mean age of 4.2 years. Cystic lymphangioma was visible in 7 cases at birth and in 6 cases before the age of 2 years, and beyond 2 years in 3 cases. The tumor was cervical in 11 cases, including one case of parotid extension, and 02 cases of sub maxillary extension, jugal in one and one case of parotid localization, and one case of lingual localization. Surgical indication was based on clinical examination and imaging in all cases. Excision was considered complete in 12 cases and incomplete in four cases. In three cases, excision was difficult due to adhesion to the internal jugular vein and the carotid bifurcation, base of the tongue in one case and facial nerve in one case. Early complications were, hematoma [one case], lymphorrhea [one case], jugal recurrence [one case] nine months after surgical excision. Conclusion: Cervico-facial cystic lymphangioma is a particular pathology whose management is challenging, complex and multidisciplinary.


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