Sertoli-Leydig Cell Tumour and DICER1 Mutation: A Case Report and Review of the Literature
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Sertoli-Leydig cell tumours of the ovary (SLCT) are rare tumours predominantly caused by mutations in the DICER1 gene. We present a patient with a unilateral SLCT who had an underlying germline DICER1 gene mutation. We discuss the underlying pathology, risks, and screening opportunities available to those with a mutation in this gene as SLCT is only one of a multitude of other tumours encompassing DICER1 syndrome. The condition is inherited in an autosomal dominant fashion. As such, genetic counselling is a key component of the management of women with SLCT.
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1990 ◽
Vol 22
(5)
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pp. 455-460
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Keyword(s):
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1986 ◽
Vol 93
(11)
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pp. 1171-1175
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2009 ◽
Vol 123
(11)
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2019 ◽
Vol Volume 12
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pp. 1127-1132
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