scholarly journals Impact of Acute Pancreatic Injury on Sphingolipid Metabolism in the Salivary Glands

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Małgorzata Żendzian-Piotrowska ◽  
Dominika M. Ziembicka ◽  
Bartłomiej Łukaszuk ◽  
Krzysztof Kurek

Acute pancreatic injury can be related to both parenchymal (responsible for exocrine functions) and islet (mainly β-cells, responsible for endocrine functions) damage. During embryonic development, both the salivary glands and the pancreas originate from the foregut, which explains many of the observed histological and functional similarities between these two organs. The relationship between several diseases of the pancreas and salivary glands, resulting from morphological and functional similarities, is well established. Sphingolipids constitute a class of biologically active molecules involved in numerous physiological and pathological processes, including acute pancreatitis (AP) and diabetes mellitus. However, the effect of AP on sphingolipid metabolism in the salivary glands remains uncertain. In the presented study, we examined the effect of AP and type 1 diabetes mellitus on sphingolipid metabolism in the salivary glands of rats. We demonstrated that acute pancreatic injury, related to both exocrine and endocrine functions, affects the metabolism of sphingolipids in the parotid, but not submandibular, salivary glands.

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Fujiko Egashira ◽  
Midori Kawashima ◽  
Ai Morikawa ◽  
Minami Kosuda ◽  
Hisamitsu Ishihara ◽  
...  

1999 ◽  
Vol 283 (1-2) ◽  
pp. 119-128 ◽  
Author(s):  
Iain R. Brown ◽  
Alasdair M. McBain ◽  
John Chalmers ◽  
Ian W. Campbell ◽  
Ewan R. Brown ◽  
...  

Author(s):  
Pedro Romero-Aroca ◽  
Juan Fernandez-Ballart ◽  
Nuria Soler ◽  
Marc Baget-Bernaldiz ◽  
Isabel Mendez-Mari

Author(s):  
Mi-Kyoung Cho ◽  
Mi Young Kim

We investigated the relationship between diabetes family conflict and parental conflict on problem recognition in illness self-management (PRISM) among individuals with type 1 diabetes mellitus (T1DM). We employed a descriptive research design. Participants were 243 individuals with T1DM who completed online questionnaires. Data were analyzed with descriptive statistics, correlations, and multiple regression analyses. Results revealed that barriers were felt in all areas (understanding and organizing care, regimen pain and bother, healthcare team interaction, family interaction, and peer interaction), especially peer interaction. The significant influencing factors in the regression model for the total PRISM score of individuals with T1DM were conflict behavior toward mothers (t = 4.44, p < 0.001), diabetes family conflict (t = 5.77, p < 0.001), conflict behavior toward fathers (t = 2.58, p = 0.011), women (t = 2.67, p = 0.008), non-religious (t = −2.33, p = 0.020), and diabetic complications (t = 2.17, p = 0.031). The explanatory power of the constructed regression model for PRISM was 42.0% (F = 30.12, p < 0.001). To promote self-management among individuals with T1DM, the development of interventions that promote improved peer interactions, a family-centered approach, and a program that can minimize conflicts between families and parents are required.


2017 ◽  
Vol 9 (04) ◽  
pp. 329-331 ◽  
Author(s):  
Prabhat Kumar ◽  
Abhishek Sakwariya ◽  
Amit Ranjan Sultania ◽  
Renu Dabas

AbstractDiabetic ketoacidosis (DKA) is a frequently encountered complication of diabetes mellitus. DKA is an insulin deficit state and results in moderate to severe hypertriglyceridemia (HTG). HTG is the third leading cause of acute pancreatitis (AP) and often goes unnoticed. The triad of DKA, HTG, and AP is rarely seen, and literature on the same is sparse. We report a case of AP which was due to DKA-induced secondary HTG in an adult with previously undiagnosed type 1 diabetes. His HbA1c was significantly raised, and C-peptide level was low, confirming chronic hyperglycemia. He was treated successfully with insulin infusion, intravenous crystalloid, and analgesics.


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