Efficacy of Electroconvulsive Therapy for Neuropathic Pain Comorbid with Major Depression

We report a case of a 41-year-old male with postinjury neuropathic pain comorbid with major depression in which electroconvulsive therapy (ECT) was effective in relieving both neuropathic pain and major depression. A total of 12 sessions of bilateral ECT were performed using a Thymatron® (Somatics LLC; Lake Bluff, IL). After ECT, the patient was subsequently maintained on paroxetine, eszopiclone (2 mg/day), and alprazolam. There was no relapse for at least one year after the last ECT. This case indicates that ECT might be an alternative treatment for major depression associated with chronic neuropathic pain after traumatic injury.

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The features of chronic neuropathic pain syndrome forming at traumatic injury of nerves of extremities

Ukrainian Neurosurgical Journal ◽

10.25305/unj.89657 ◽

2010 ◽

Vol 0 (2) ◽

pp. 51-54

Author(s):

V. I. Tsymbaliuk ◽

S. N. Nelepin ◽

A. N. Nikiforova ◽

N. A. Sapon

Keyword(s):

Neuropathic Pain ◽

Traumatic Injury ◽

Pain Syndrome ◽

Chronic Neuropathic Pain ◽

Neuropathic Pain Syndrome

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A one year open label assessment of the use of nabilone in the treatment of chronic neuropathic pain

http://isrctn.org/> ◽

10.1186/isrctn38408594 ◽

2012 ◽

Author(s):

Dilip Kapur

Keyword(s):

Neuropathic Pain ◽

Open Label ◽

Chronic Neuropathic Pain ◽

One Year

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Robust and Sustained Effect of Ketamine Infusions Coadministered with Conventional Antidepressants in a Patient with Refractory Major Depression

Case Reports in Psychiatry ◽

10.1155/2015/815673 ◽

2015 ◽

Vol 2015 ◽

pp. 1-3

Author(s):

José Manuel Montes ◽

Elena Luján ◽

Fernado Pascual ◽

Jose María Beleña ◽

Jose Luis Perez-Santar ◽

...

Keyword(s):

Major Depression ◽

Transient Response ◽

Electroconvulsive Therapy ◽

Alternative Treatment ◽

Potential Role ◽

Antidepressant Treatments ◽

Sustained Effect ◽

Resistant Depression

Antidepressant treatments show low capacity to achieve full clinical remissions. Electroconvulsive therapy is an alternative treatment which has been shown to be more effective but it is not well tolerated and there are concerns regarding its safety. We present the case of a patient with resistant depression and modest and transient response to ECT and who showed a robust and maintained response after six i.v. ketamine (0.5 mg/kg) infusions without withdrawing her antidepressant regimen. Ketamine was very well tolerated. This case illustrates the potential role of ketamine as a booster to standard antidepressants.

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