scholarly journals Variations in Aggressive and Indolent Behaviour of Central Dentinogenic Ghost Cell Tumor

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Radhika Manoj Bavle ◽  
Sudhakara Muniswamappa ◽  
Soumya Makarla ◽  
Reshma Venugopal

Among the aggressive odontogenic tumors, a few tumors generally ameloblastomas, carry a connotation of being aggressive. But, a rare tumor like central dentinogenic ghost cell tumor (DGCT) can be equally aggressive with a propensity for recurrence. The two cases discussed in this article are divergent in behaviour with features such as presentation, seen in early decades as central intraosseous tumors in the maxilla and mandible. The first case describes an aggressive DGCT, associated with impacted tooth and odontome which showed recurrence into a large solid tumor within a year. The second case arose in accordance with a partially erupted molar which was comparatively innocuous and less aggressive. Both the cases exhibited classic histopathological features. These two unconventional cases of DGCT with a follow-up are being reported here to highlight the variation in behaviour and presentation and also to understand the aggressive nature of the tumor.

2014 ◽  
Vol 117 (5) ◽  
pp. 626-633 ◽  
Author(s):  
Wagner Gomes da Silva ◽  
Teresa Cristina Ribeiro Bartholomeu dos Santos ◽  
Márcia Grillo Cabral ◽  
Rebeca Souza Azevedo ◽  
Fábio Ramôa Pires

2021 ◽  
Author(s):  
Yuri Noda ◽  
Chisato Ohe ◽  
Mitsuaki Ishida ◽  
Kimiaki Okano ◽  
Kaori Sando ◽  
...  

Abstract Background: Odontogenic tumors arising from extra-alveolar sites are extremerly rare. Dentinogenic ghost cell tumor (DGCT) is an uncommon odontogenic neoplasm characterized by CTNNB1 mutation, ghost cell appearance, and dentinoid-like calcification. We present a case of an ectopic DGCT arising from a calcifying odontogenic cyst in the floor of the mouth. Case presentation: A 72-year-old man presented with a painless sublingual swelling. Imaging revealed a multi-lobulated, solid-cyst mass on the floor of the mouth. Cytology showed folded epithelial clusters composed of basaloid cells, keratinized material, and dentinoid matrix. Histology also revealed a multi-cystic, cribriform to solid nest. Immunohistochemically, CK19, CK5/6, bcl-2, and p63 were diffuse positive. CTNTTB1 mutation was detected, leading to the final diagnosis of an ectopic DGCT. There was no recurrence during a 6-month follow-up. Conclusion: This is the first report to comprehensively describe the clinicopathological features of an ectopic DGCT of odontogenic origin, developing similarly to that of a true odontogenic DGCT. Accurate diagnosis of this rare entity is necessary to avoid overtreatment.


2015 ◽  
Vol 49 (1) ◽  
pp. 56 ◽  
Author(s):  
Merva Soluk Tekkeşin ◽  
Mehmet Ali Erdem ◽  
Nedim Özer ◽  
Vakur Olgaç

2016 ◽  
Vol 20 (1) ◽  
pp. 163 ◽  
Author(s):  
SweetySagarmal Bafna ◽  
Tabita Joy ◽  
JagdishVishnu Tupkari ◽  
JayantShivaji Landge

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Uddipan Kumar ◽  
Hitesh Vij ◽  
Ruchieka Vij ◽  
Jitin Kharbanda ◽  
IN Aparna ◽  
...  

Dentinogenic ghost cell tumor (DGCT) is an uncommon locally invasive odontogenic tumor regarded by many as a variant of calcifying odontogenic cyst. The peripheral variant of this clinical rarity appears as a well-circumscribed mass mimicking a nonspecific gingival enlargement. Microscopic appearance of odontogenic epithelium admixed with focal areas of dentinoid formation and sheets of ghost cells giving the definitive diagnosis of dentinogenic ghost cell tumor imply that microscopic examination is compulsory for any gingival mass. Van Gieson histochemical stain further confirmed the nature of dentinoid-like material. A complete workup of a case of peripheral dentinogenic ghost cell tumor is presented in this paper and the current concept as well as the appraisal of literature is presented.


2020 ◽  
Vol 129 (1) ◽  
pp. e140-e141
Author(s):  
ISADORA PEREIRA GOMES ◽  
JOSÉ ALCIDES ALMEIDA ARRUDA ◽  
ELISMAURO FRANCISCO DE MENDONÇA ◽  
ELENA RIET CORREA RIVERO ◽  
BRUNO AUGUSTO BENEVENUTO DE ANDRADE ◽  
...  

2009 ◽  
Vol 38 (11) ◽  
pp. 1179-1183 ◽  
Author(s):  
G. Sun ◽  
X. Huang ◽  
Q. Hu ◽  
X. Yang ◽  
E. Tang

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