scholarly journals The Migration of Human Follicular Dendritic Cell-Like Cell Is Facilitated by Matrix Metalloproteinase 3 Expression That Is Mediated through TNFα-ERK1/2-AP1 Signaling

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Hyo-Kyung Pak ◽  
Yong-Woo Kim ◽  
Bora Nam ◽  
A-Neum Lee ◽  
Jin Roh ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Follicular Dendritic Cell ◽  
Therapeutic Modality ◽  
Control Mechanisms ◽  
Follicular Dendritic Cells ◽  
Molecular Control ◽  
Matrix Metalloproteinase 3 ◽  
Follicular Dendritic ◽  
Factor Α

Follicular dendritic cells are important stromal components of the germinal center (GC) and have pivotal roles in maintaining the GC microenvironment for high-affinity antibody production. Tumor necrosis factor-α (TNFα) is essential for the development and functions of follicular dendritic cells. Despite the importance of follicular dendritic cells in humoral immunity, their molecular control mechanisms have yet to be fully elucidated due to the lack of an adequate investigation system. Here, we have used a unique human primary follicular dendritic cell-like cell (FDCLC) to demonstrate that the migration of these cells is enhanced by TNFα-mediated metalloproteinase 3 (MMP3) expression. MMP3 was found to be highly expressed in normal human GCs and markedly upregulated in human primary FDCLCs by TNFα. TNFα induced ERK1/2 phosphorylation and the transcription of MMP3 through AP1. TNFα treatment increased FDCLC migration, and a knockdown of MMP3 significantly reduced the TNFα-induced migration of FDCLCs. Overall, we have newly identified a control mechanism for the expression of MMP3 in FDCLCs that modulates their migration and may indicate an important role in GC biology. Since GCs are observed in the lesions of autoimmune diseases and lymphomas, targeting the MMP3/TNFα-mediated migration of stromal cells in the B cell follicle may have great potential as a future therapeutic modality against aberrant GC-associated disorders.

Human follicular dendritic cells in vitro and follicular dendritic-cell-like cells

1997 ◽  
Vol 288 (2) ◽  
pp. 381-389 ◽  
Author(s):  
Rikiya Tsunoda ◽  
Alain Bosseloir ◽  
Kikuo Onozaki ◽  
Ernst Heinen ◽  
Katsuya Miyake ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Follicular Dendritic Cell ◽  
Follicular Dendritic Cells ◽  
Follicular Dendritic

scholarly journals Rate of immune complex cycling in follicular dendritic cell determines the extent of protecting antigen integrity and availability to germinal center B cells1

2020 ◽  
Author(s):  
Theinmozhi Arulraj ◽  
Sebastian C. Binder ◽  
Michael Meyer-Hermann
Keyword(s):  
Experimental Data ◽  
Dendritic Cells ◽  
Germinal Center ◽  
Follicular Dendritic Cell ◽  
Follicular Dendritic Cells ◽  
Average Residence Time ◽  
Antigen Concentration ◽  
Time Periods ◽  
Follicular Dendritic ◽  
Cycling Time

AbstractFollicular Dendritic Cells (FDCs) retain immune complexes (ICs) for prolonged time periods and are important for germinal center (GC) reactions. ICs undergo periodic cycling in FDCs, a mechanism supporting an extended half-life of antigen. Based on experimental data we estimated that the average residence time of Phycoerythrin-ICs (PE-ICs) on FDC surface and interior were 21 and 36 minutes, respectively. GC simulations show that antigen cycling might impact GC dynamics due to redistribution of antigen on the FDC surface and by protecting antigen from degradation. Antigen protection and influence on GC dynamics varied with antigen cycling time and total antigen concentration. Simulations predict that blocking antigen cycling terminates the GC reaction and decreases plasma cell production. Considering that cycling of antigen could be a target for the modulation of GC reactions, our findings highlight the importance of understanding the mechanism and regulation of IC cycling in FDCs.

scholarly journals Paraneoplastic Pemphigus Associated with Follicular Dendritic Cell Tumor in the Mediastinum

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Aparna Mullangath Prakasan ◽  
Anne Jennifer Prabhu ◽  
Kanmani Velarasan ◽  
Selvamani Backianathan ◽  
Thomas Samuel Ram
Keyword(s):  
Dendritic Cell ◽  
Follicular Dendritic Cell ◽  
Follicular Dendritic Cells ◽  
Paraneoplastic Pemphigus ◽  
Bullous Disease ◽  
Autoimmune Bullous Disease ◽  
Underlying Malignancy ◽  
Follicular Dendritic ◽  
High Index Of Suspicion ◽  
Disease Free

Paraneoplastic Pemphigus (PNP) is an autoimmune bullous disease characterized by severe stomatitis, polymorphous skin eruptions, and underlying neoplasms. Diagnosis of cutaneous paraneoplastic disorders requires high index of suspicion. We describe a patient with PNP associated with follicular dendritic cell (FDC) tumor in the mediastinum, a rare neoplasm originating from follicular dendritic cells. Its management requires identification of underlying malignancy and treatment of the same. Our patient showed remission of PNP upon excision of the tumor and remained disease-free for 8 years.

scholarly journals Angioimmunoblastic T-Cell Lymphoma: A Questionable Association with Follicular Dendritic Cell Sarcoma

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Daniel Benharroch ◽  
Miriam Zekzer ◽  
Karen Nalbandyan
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Cell Lymphoma ◽  
Follicular Dendritic Cell ◽  
T Cell Lymphoma ◽  
Follicular Dendritic Cell Sarcoma ◽  
Follicular Dendritic Cells ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Dendritic Cell Sarcoma ◽  
Follicular Dendritic

An elderly woman presented with generalized lymphadenopathy, several systemic symptoms, and splenomegaly. An inguinal lymph node excision revealed a compound picture. One aspect of the lymph node morphology, including cells with follicular T-helper cell phenotype, was most consistent with angioimmunoblastic T-cell lymphoma. The other component, revealing spindle cells forming whorls with immunostaining for CD21, CD23, and fascin, might be an integral part of this T-cell lymphoma. However, due to the often massive involvement of the nodal tissue by these follicular dendritic cells, these areas were questionably suggestive of involvement by follicular dendritic cell sarcoma. We raise herein the issue of the borderline area between advanced follicular dendritic cell expansion in angioimmunoblastic T-cell lymphoma and a massive follicular dendritic cell proliferation consistent with follicular dendritic cells sarcoma, in the absence of a genomic analysis.

scholarly journals Follicular Dendritic Cell Sarcoma

2016 ◽  
Vol 140 (2) ◽  
pp. 186-190 ◽  
Author(s):  
Annie Wu ◽  
Sheeja Pullarkat
Keyword(s):  
Dendritic Cell ◽  
Follicular Dendritic Cell ◽  
Follicular Dendritic Cell Sarcoma ◽  
Follicular Dendritic Cells ◽  
Braf Mutations ◽  
Cell Sarcoma ◽  
Diagnostic Pitfall ◽  
Dendritic Cell Sarcoma ◽  
Follicular Dendritic

Follicular dendritic cell sarcoma is an uncommon neoplastic proliferation of spindled to ovoid cells with morphologic and immunophenotypic features similar to normal follicular dendritic cells. While most follicular dendritic cell sarcomas arise from lymph nodes, at least one-third occur in extranodal sites. A broad differential diagnosis can be developed—as this tumor has morphologic features similar to other tumors, hence creating a diagnostic pitfall—but its immunophenotypic profile is quite specific and is diagnostically crucial. Herein, we review the pathogenesis; histologic morphology; and immunohistochemical, electron microscopy, and clinical features, including treatment and prognosis, of follicular dendritic cell sarcomas. We will briefly describe the role of molecular studies including utility of BRAF mutations in diagnosing this tumor.

Extranodal Follicular Dendritic Cell Sarcoma

2008 ◽  
Vol 132 (10) ◽  
pp. 1683-1687 ◽  
Author(s):  
Kenneth E. Youens ◽  
Michael S. Waugh
Keyword(s):  
Dendritic Cell ◽  
Follicular Dendritic Cell ◽  
Follicular Dendritic Cell Sarcoma ◽  
Rare Tumor ◽  
Follicular Dendritic Cells ◽  
Cell Sarcoma ◽  
Dendritic Cell Sarcoma ◽  
Follicular Dendritic ◽  
Ancillary Studies ◽  
Worse Prognosis

Abstract Extranodal follicular dendritic cell sarcoma is a rare tumor of follicular dendritic cells that can occur in a wide variety of sites. Although fairly well characterized histologically, with a distinct immunophenotype, it remains underrecognized, with as many as one third of cases initially misdiagnosed. This is often due to a failure to consider the entity. Patients with this tumor may have a worse prognosis than originally described. Prompted by a recent case at our institution, we briefly review the clinical features, etiology, histologic, and cytologic appearance of the tumor, as well as the ancillary studies useful in resolving diagnostic issues, primarily in an attempt to increase recognition of this rare neoplasm.

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