scholarly journals Usefulness of Transurethral Incision as a Primary Treatment of Ureterocele in Children

1996 ◽  
Vol 2 (4) ◽  
pp. 189-196 ◽  
Author(s):  
Ichiro Takeuchi ◽  
Katsuya Nonomura ◽  
Koichi Kanagawa ◽  
Tetsufumi Yamashita ◽  
Hidehiro Kakizaki ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Renal Function ◽  
Urinary Tract ◽  
Tract Infection ◽  
De Novo ◽  
Primary Treatment ◽  
Single System ◽  
Normal Kidney ◽  
Duplex System ◽  
Transurethral Incision

Seventeen patients (11 girls and 6 boys, with bilateral cases in 4 for a total 21 units), in whom ureterocele was diagnosed at from 5 days to 11 years old, were treated with transurethral incision as a primary treatment. Urinary tract infection was the most common presenting sign in 8 patients. A voiding disturbance was observed in 10 patients. Seven units were diagnosed as intravesical ureteroceles of a single system and 14 units as ectopic ones (12 associated with the duplex system and 2 with a single system). De novo reflux occurred in 12 units, but in 5 units resolved spontaneously. All 5 refluxes in mate units improved, and 2 refluxes in the contralateral ureter also disappeared. The control of infection became easy in all patients except for one with a sphincteric ureterocele. Split renal function on T99mc-diethylenetriamine pentaacetic acid scintigraphy was prominently improved in 5 systems (35.7%) and normal kidney growth was obtained in 11 systems (78.6%). A total of 13 affected units (68.4%), including 7 units (6 intravesical and 1 ectopic) for which transurethral incision seemed to have been the sole necessary treatment, were saved. We believe that transurethral incision of ureteroceles is a very useful technique as a primary treatment for all types of ureteroceles in children of all ages.

scholarly journals Population Pharmacokinetic and Pharmacokinetic/Pharmacodynamic Analyses of Cefiderocol, a Parenteral Siderophore Cephalosporin, in Patients with Pneumonia, Bloodstream Infection/Sepsis, or Complicated Urinary Tract Infection

2020 ◽  
Author(s):  
Nao Kawaguchi ◽  
Takayuki Katsube ◽  
Roger Echols ◽  
Toshihiro Wajima
Keyword(s):  
Urinary Tract Infection ◽  
Renal Function ◽  
Urinary Tract ◽  
Tract Infection ◽  
Bloodstream Infection ◽  
Plasma Concentrations ◽  
Complicated Urinary Tract Infection ◽  
Population Pharmacokinetic ◽  
Dosing Regimen ◽  
Population Pk

Cefiderocol is a novel siderophore cephalosporin with antibacterial activity against Gramnegative bacteria including carbapenemresistant strains. The standard dosing regimen of cefiderocol is 2 g administered every 8 hours over 3 hours infusion in patients with creatinine clearance (CrCL) of 60 to 119 mL/min, and it is adjusted for patients with < 60 mL/min or ≥ 120 mL/min CrCL. A population pharmacokinetic (PK) model was constructed using 3427 plasma concentrations from 91 uninfected subjects and 425 infected patients with pneumonia, bloodstream infection/sepsis (BSI/sepsis), and complicated urinary tract infection (cUTI). Plasma cefiderocol concentrations were adequately described by the population PK model, and CrCL was the most significant covariate. No other factors including infection sites and mechanical ventilation were clinically relevant, although the effect of infection sites was identified as a statistically significant covariate in the population PK analysis. No clear pharmacokinetic/pharmacodynamic relationship was found for any of the microbiological outcome, clinical outcome, or vital status. This is because the estimated percentage of time for which free plasma concentrations exceed the minimum inhibitory concentration (MIC) over dosing interval (%fT>MIC) was 100% in most of the enrolled patients. The probability of target attainment (PTA) for 100% fT>MIC was > 90% against MICs ≤ 4 μg/mL for all infection sites and renal function groups except for BSI/sepsis patients with normal renal function (85%). These study results support adequate plasma exposure can be achieved at the cefiderocol recommended dosing regimen for the infected patients including the patients with augmented renal function, ventilation, and/or severe illness.

scholarly journals Anderson-Hynes Pyeloplasty in Children: Nonintubated Versus Intubated

2012 ◽  
Vol 35 (2) ◽  
pp. 59-61
Author(s):  
Gazi Zahirul Hasan ◽  
AKM Zahid Hossain ◽  
Md Ruhul Amin ◽  
Shafiqul Hoque ◽  
MTH Siddiqui
Keyword(s):  
Urinary Tract Infection ◽  
Renal Function ◽  
Urinary Tract ◽  
Tract Infection ◽  
Hospital Stay ◽  
Paediatric Surgery ◽  
Dhaka City ◽  
Additional Advantage ◽  
Differential Renal Function ◽  
Medical University

Objective: To compare between nonintubated versus intubated Anderson-Hynes (AH) pyeloplasty in children.Study Design: Prospective studyStudy place: Department of Paediatric Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh and some private clinics of Dhaka city. Study period: March 2001 to December 2008.Subjects: A total of 75 patients were included in this study. They were divided in two groups. Nonintubated Anderson-Hynes pyeloplasty was done in 45 patients and intubated Anderson-Hynes pyeloplasty was done in 30 patients.Results: The anastomotic leakage of urine, urinary tract infection, hospital stay and improvement of differential renal function were assessed post operatively in both nonintubated and intubated groups. This study showed that there was no anastomotic failure and no post operative urinary tract infection in either group. The percentage of improvement of differential renal function is almost same in both the groups. The post operative hospital stay was markedly reduced in nonintubated Anderson-Hynes pyeloplasty. In this study the post operative hospital stay in nonintubated group was average 6 days and it was average 16.5 days in intubated group.Conclusion: From this study it may be concluded that the effects of nonintubated AH pyeloplasty is as good as intubated one but an additional advantage of significantly less post operative hospital stay was observed in nonintubated group.DOI: http://dx.doi.org/10.3329/bjch.v35i2.10378  Bangladesh J Child Health 2011; Vol 35 (2): 59-61

scholarly journals Renal Function 16 to 26 Years After the First Urinary Tract Infection in Childhood

2000 ◽  
Vol 154 (4) ◽  
pp. 339 ◽  
Author(s):  
Martin Wennerström ◽  
Sverker Hansson ◽  
Ulf Jodal ◽  
Rune Sixt ◽  
Eira Stokland
Keyword(s):  
Urinary Tract Infection ◽  
Renal Function ◽  
Urinary Tract ◽  
Tract Infection

Renal function in adult women with urinary tract infection in childhood

2015 ◽  
Vol 30 (9) ◽  
pp. 1493-1499 ◽  
Author(s):  
Carin Gebäck ◽  
Sverker Hansson ◽  
Jeanette Martinell ◽  
Torsten Sandberg ◽  
Rune Sixt ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Renal Function ◽  
Urinary Tract ◽  
Tract Infection ◽  
Adult Women

Extended Therapy in Patients with Established Urinary Tract Infection

1971 ◽  
Vol 16 (3) ◽  
pp. 169-172
Author(s):  
D. H. Lawson ◽  
R. I. Gleadle ◽  
A. L. Linton
Keyword(s):  
Urinary Tract Infection ◽  
Renal Function ◽  
Urinary Tract ◽  
Tract Infection ◽  
Recurrence Rate ◽  
Impaired Renal Function ◽  
Renal Damage ◽  
Initial Therapy ◽  
Intravenous Pyelography ◽  
Acute Urinary Tract Infection

Sixty-six patients with established urinary tract infection were given a 3-month course of antibacterial therapy and the effect of this upon the recurrence rate of urine infections investigated. Even in patients with no radiological evidence of renal damage the recurrence rate was 40 per cent at 2 years and this rose to 75 per cent in the group with impaired renal function and abnormalities present on intravenous pyelography. It is concluded that an initial 10 day course of therapy is indicated in females suffering from their first or second attack of acute urinary tract infection. If this becomes established, a 3-month course of therapy is suggested and following this, further recurrences demand careful renal investigation. In the male, all cases of urinary tract infection should be investigated after the initial therapy. Finally, the management of those patients with no anatomical lesion who suffer from recurrent attacks of infection after a 3-month course of therapy has not yet been clearly defined. There is no evidence that either ampicillin, nitrofurantoin or nalidixic acid is superior to sulphadimidine in the treatment of patients with established urinary tract infection.

A 8-Year-Forgotten Ureteral Stent after Kidney Transplantation: Treatment and Long-term Follow-up

2013 ◽  
Vol 80 (1) ◽  
pp. 80-82 ◽  
Author(s):  
Fedele Lasaponara ◽  
Ettore Dalmasso ◽  
Silvia Santià ◽  
Omidreza Sedigh ◽  
Andrea Bosio ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Renal Function ◽  
Urinary Tract ◽  
Tract Infection ◽  
Graft Loss ◽  
Ureteral Stent ◽  
Urological Complications ◽  
Long Term Follow Up ◽  
Forgotten Ureteral Stent

Introduction Forgotten indwelling ureteral stents can cause significant urological complications. Only few cases are reported after kindney transplantation. Materials and Methods We present a case of a 39-year-old woman, transplanted in 1993 and referred to our Transplant Center 8 years later, because of a serious urinary tract infection with renal function impairment. Abdominal CT scan showed pyelonephritis and hydronephrosis in the transplanted kidney and the presence of a calcific ureteral stent, which had been forgotten in situ for 8 years. The stent was removed, but it was impossibile to replace it with a new stent both retrogradely and anterogradely, because of a tight obstruction of the mid ureter. So a uretero-ureteral anastomosis with up urinary tract was performed. Results No intra- or post-operative complications occurred. At 9 years’ follow-up, the patient shows an optimal renal function, with no urinary tract infection. Discussion A forgotten ureteral stent in a trasplanted kidney can cause a lot of complications and can lead to graft loss. The prosthesis may cause an irreversibile ureteral damage, so, as in our experience, forgetting a ureteral stent can result in a complex surgery.

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