scholarly journals Trypanosoma Cruzi-Induced Host Immune System Dysfunction: A Rationale for Parasite Immunosuppressive Factor(s) Encoding Gene Targeting

2001 ◽  
Vol 1 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Ali Ouaissi ◽  
Anabela Cordeiro Da Silva ◽  
Angel Gustavo Guevara ◽  
Margarida Couthino ◽  
Eliane Guilvard
1991 ◽  
Vol 142 (2) ◽  
pp. 125-126 ◽  
Author(s):  
M. Hontebeyrie-Joskowicz ◽  
P. Minoprio

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
José M. Álvarez ◽  
Raissa Fonseca ◽  
Henrique Borges da Silva ◽  
Cláudio R. F. Marinho ◽  
Karina R. Bortoluci ◽  
...  

Over the past 20 years, the immune effector mechanisms involved in the control ofTrypanosoma cruzi, as well as the receptors participating in parasite recognition by cells of the innate immune system, have been largely described. However, the main questions on the physiopathology of Chagas disease remain unanswered: “Why does the host immune system fail to provide sterile immunity?” and “Why do only a proportion of infected individuals develop chronic pathology?” In this review, we describe the mechanisms proposed to explain the inability of the immune system to eradicate the parasite and the elements that allow the development of chronic heart disease. Moreover, we discuss the possibility that the inability of infected cardiomyocytes to sense intracellularT. cruzicontributes to parasite persistence in the heart and the development of chronic pathology.


2002 ◽  
Vol 4 (9) ◽  
pp. 1007-1013 ◽  
Author(s):  
George A. DosReis ◽  
Lígia M.T. Peçanha ◽  
Maria Bellio ◽  
José O. Previato ◽  
Lúcia Mendonça-Previato

Science ◽  
2007 ◽  
Vol 317 (5836) ◽  
pp. 376-381 ◽  
Author(s):  
N. Stern-Ginossar ◽  
N. Elefant ◽  
A. Zimmermann ◽  
D. G. Wolf ◽  
N. Saleh ◽  
...  

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 259-261
Author(s):  
Aamir Khan ◽  
Rajni K. Gurmule

Vasavaleha is one of the best medicine given for respiratory diseases. Corona viruses typically affect the respiratory system, causing symptoms such as coughing, fever and shortness of breath. It also affects host immune system of human body. Spreading rate of this disease is very high. Whole world is seeking for the treatment which can uproots this diseases. There in no vaccine available till date against this pandemic disease. Ayurveda mainly focuses on prevention of diseases alongwith its total cure. Rajyakshma Vyadhi is MadhyamMarga Roga as per Ayurveda. It shows many symptoms such as Kasa, Shwasa etc. By overall view of Covid 19, shows its resemblance with Rajyakshma Vyadhi described in Ayurveda. Vasavaleha is a Kalpa which is described in Rogadhikara of Rajyakshma. It shows Kasahara, Shwashara properties. It consists of Vasa, Pipalli, Madhu and Goghrita. These components shows actions like bronchodilation, antitussive effect and many more other actions. Pipalli shows important Rasayana effect. So in present review, we have tried to focus on role of Vasavaleha in the management of Covid 19. This can be used as preventive as well as adjuvant medication in treating Covid 19. There is need of further clinical research to rule of exact action of Vasavaleha against Covid 19.


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