Upper gastrointestinal symptoms in type 2 diabetes mellitus and detection of gastric emptying by ultrasongraphy

2008 ◽  
Vol 16 (23) ◽  
pp. 2653
Author(s):  
Chun-Tao Li ◽  
Ye Zhang
Author(s):  
A. E. Shklyaev ◽  
D. D. Kazarin ◽  
Y. V. Gorbunov

The constant increase in the incidence of diabetes in the world and the high frequency of lesions of the upper gastrointestinal tract with impaired motor function in this category of patients, on the one hand, worsen the clinical picture, and on the other, reduce the effectiveness of sugar-lowering therapy. Currently, specialists have at their disposal a number of prokinetics that contribute to the restoration of the motor-evacuation function of the stomach, but many of them have many undesirable effects. The aim of our study was to evaluate the effectiveness of itopride hydrochloride in the treatment of patients with chronic gastritis associated with Helicobacter pylori and type 2 diabetes. During the study, both general clinical and more specific research methods were used, in particular, esophagogastroduodenoscopy. According to the results of the study, the use of prokinetics in the treatment of patients with type 2 diabetes mellitus reduces the manifestations of impaired motor-evacuation function of the upper gastrointestinal tract. The results obtained indicate to verify the manifestations of chronic gastritis in patients with type 2 diabetes mellitus and the identification of motor dysfunction and the need for prokinetic therapy.


1998 ◽  
Vol 15 (12) ◽  
pp. 1022-1027 ◽  
Author(s):  
C. Weytjens ◽  
B. Keymeulen ◽  
C. Van Haleweyn ◽  
G. Somers ◽  
A. Bossuyt

2016 ◽  
Vol 35 (5) ◽  
pp. 385-392 ◽  
Author(s):  
Venkata Anudeep ◽  
Kolar Vishwanath Vinod ◽  
Nandini Pandit ◽  
Vivek Kumar Sharma ◽  
Halanaik Dhanapathi ◽  
...  

2003 ◽  
Vol 124 (4) ◽  
pp. A94
Author(s):  
Amelia Pilichiewicz ◽  
Deirdre O'Donovan ◽  
Christine Feinle ◽  
Yong Lei ◽  
Laura Bryant ◽  
...  

2012 ◽  
Vol 142 (5) ◽  
pp. S-839 ◽  
Author(s):  
Adil E. Bharucha ◽  
Ananda Basu ◽  
Erica B. Veil ◽  
Yogish C. Kudva ◽  
Michael Camilleri ◽  
...  

2019 ◽  
Vol 51 (04) ◽  
pp. 267-273
Author(s):  
Christelle Beti ◽  
Bernd Stratmann ◽  
Georgy Bokman ◽  
Jens Dreier ◽  
Michael Hauber ◽  
...  

AbstractThe effect of the treatment with glucagon-like peptide (GLP)-1 receptor agonists on gastric emptying in patients with diabetes with and without gastroparesis is analysed. Patients with type 2 diabetes mellitus subjected to GLP-1 receptor agonist therapy with exenatide were examined before and shortly after initiation of treatment. Gastric half-emptying time was determined by 13C-octanoic breath test; routine laboratory parameter as well as active GLP-1, ghrelin, leptin, insulin, proinsulin and C-peptide levels were determined in fasting state as well as postprandial secretion within 1 h after a standardised meal. Thirty patients’ data sets were available for evaluation, of those 20 patients had no gastroparesis and 10 patients showed pathological results following the breath test. Gastric half-emptying time was prolonged in nearly all patients who presented without gastroparesis at initiation of treatment with GLP-1 receptor agonists, only 2 patients with pre-existing mild gastroparesis had worsening of gastric emptying. No effect was detected on leptin and ghrelin levels. Postprandial GLP-1 concentrations measured as AUC after meal decreased significantly. Fasting insulin and C-peptide levels increased significantly without effect on postprandial levels. Proinsulin levels – fasting as well as AUC – decreased non-significantly. Patients reported comparable perception of therapeutic effects. Treatment with GLP-1 receptor agonists may be applied in patients with pre-existing gastroparesis; no effect in terms of worsening of symptoms compared to those without gastroparesis was detected. Patients reported outcome was independent from underlying gastroparesis. Negative effects on gastric emptying were only detected in patients without or with mild gastroparesis.


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