Impaired Dihydrotestosterone Catabolism in Human Prostate Cancer: Critical Role of AKR1C2 as a Pre-Receptor Regulator of Androgen Receptor Signaling

2007 ◽  
Vol 67 (3) ◽  
pp. 1361-1369 ◽  
Author(s):  
Qing Ji ◽  
Lilly Chang ◽  
Frank Z. Stanczyk ◽  
Murad Ookhtens ◽  
Andy Sherrod ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Critical Role ◽  
Human Prostate ◽  
Receptor Signaling ◽  
Human Prostate Cancer ◽  
Androgen Receptor Signaling

scholarly journals Cell-autonomous intracellular androgen receptor signaling drives the growth of human prostate cancer initiating cells

The Prostate ◽  
2009 ◽  
Vol 70 (1) ◽  
pp. 90-99 ◽  
Author(s):  
Donald J. Vander Griend ◽  
Jason D'Antonio ◽  
Bora Gurel ◽  
Lizamma Antony ◽  
Angelo M. DeMarzo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Human Prostate ◽  
Receptor Signaling ◽  
Human Prostate Cancer ◽  
Androgen Receptor Signaling

scholarly journals Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling

2010 ◽  
Vol 49 (10) ◽  
pp. 902-912 ◽  
Author(s):  
Gagan Deep ◽  
Subhash C. Gangar ◽  
Nicholas H. Oberlies ◽  
David J. Kroll ◽  
Rajesh Agarwal
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Human Prostate ◽  
Receptor Signaling ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Androgen Receptor Signaling

scholarly journals Interplay Between SOX9, Wnt/β-Catenin and Androgen Receptor Signaling in Castration-Resistant Prostate Cancer

2019 ◽  
Vol 20 (9) ◽  
pp. 2066 ◽  
Author(s):  
Namrata Khurana ◽  
Suresh C. Sikka
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Signaling Pathways ◽  
Critical Role ◽  
Castration Resistant Prostate Cancer ◽  
Form Complex ◽  
Androgen Receptor Signaling ◽  
Castration Resistant ◽  
Signaling Axis

Androgen receptor (AR) signaling plays a key role not only in the initiation of prostate cancer (PCa) but also in its transition to aggressive and invasive castration-resistant prostate cancer (CRPC). However, the crosstalk of AR with other signaling pathways contributes significantly to the emergence and growth of CRPC. Wnt/β-catenin signaling facilitates ductal morphogenesis in fetal prostate and its anomalous expression has been linked with PCa. β-catenin has also been reported to form complex with AR and thus augment AR signaling in PCa. The transcription factor SOX9 has been shown to be the driving force of aggressive and invasive PCa cells and regulate AR expression in PCa cells. Furthermore, SOX9 has also been shown to propel PCa by the reactivation of Wnt/β-catenin signaling. In this review, we discuss the critical role of SOX9/AR/Wnt/β-catenin signaling axis in the development and progression of CRPC. The phytochemicals like sulforaphane and curcumin that can concurrently target SOX9, AR and Wnt/β-catenin signaling pathways in PCa may thus be beneficial in the chemoprevention of PCa.

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