Curcumin Suppresses the Paclitaxel-Induced Nuclear Factor-κB Pathway in Breast Cancer Cells and Inhibits Lung Metastasis of Human Breast Cancer in Nude Mice

2005 ◽  
Vol 11 (20) ◽  
pp. 7490-7498 ◽  
Author(s):  
Bharat B. Aggarwal ◽  
Shishir Shishodia ◽  
Yasunari Takada ◽  
Sanjeev Banerjee ◽  
Robert A. Newman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Lung Metastasis ◽  
Nude Mice ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Human Breast

scholarly journals Inverse effects of 20K and 22K human growth hormones on the growth of T-47D human breast cancer cells in culture and in nude mice

IUBMB Life ◽  
1998 ◽  
Vol 46 (4) ◽  
pp. 719-724
Author(s):  
Takahiko Fujikawa ◽  
Hiroshi Kaneko ◽  
Hiroshige Hibasami ◽  
Kesami Sakaguchi ◽  
Khorshed Alam ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Nude Mice ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Growth ◽  
Growth Hormones ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cells In Culture

scholarly journals Activation of a Nuclear Factor κB/Interleukin-1 Positive Feedback Loop by Amphiregulin in Human Breast Cancer Cells

2007 ◽  
Vol 5 (8) ◽  
pp. 847-861 ◽  
Author(s):  
Katie L. Streicher ◽  
Nicole E. Willmarth ◽  
Jose Garcia ◽  
Julie L. Boerner ◽  
T. Gregory Dewey ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Feedback Loop ◽  
Interleukin 1 ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Positive Feedback Loop

scholarly journals Wortmannin Reduces Metastasis and Angiogenesis of Human Breast Cancer Cells via Nuclear Factor-κB-Dependent Matrix Metalloproteinase-9 and Interleukin-8 Pathways

2012 ◽  
Vol 40 (3) ◽  
pp. 867-876 ◽  
Author(s):  
J Li ◽  
F Li ◽  
H Wang ◽  
X Wang ◽  
Y Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Enzyme Linked Immunosorbent Assay ◽  
Nuclear Factor ◽  
Human Breast

OBJECTIVE: To investigate whether inhibition of Akt phosphorylation by the phosphatidylinositol 3-kinase (PI3K) inhibitor, wortmannin, reduces metastasis and angiogenesis in a human breast cancer cell line via nuclear factor (NF)-κB-dependent matrix metalloproteinase (MMP)-9 and interleukin (IL)-8 pathways. METHODS: MDA-MB-231 cells were treated with wortmannin 0 – 200 nM for 4 h. Restoration of Akt activity was evaluated by transfection of cells with constitutively active myristoylated Akt (myr-Akt). NF-κB, MMP-9 and IL-8 proteins were detected by electrophoretic mobility shift assay, Western blot or enzyme-linked immunosorbent assay. The chicken embryo chorio-allantoic membrane assay, cell motility and migration assays were used to evaluate angiogenesis and invasion in vitro. A mouse pseudo metastatic breast cancer model was used to assess the effects of wortmannin on metastasis and angiogenesis in vivo. RESULTS: Wortmannin inhibited the phosphorylation of Akt, upregulation of NF-κB, MMP-9, IL-8, and in vitro cell invasion and angiogenesis, in a dose-dependent manner. Transfection of myr-Akt reversed the cellular and biochemical effects of wortmannin in vitro. Wortmannin also significantly inhibited tumour metastasis and angiogenesis in vivo. CONCLUSION: The findings of the present study suggest that wortmannin inhibits metastasis and angiogenesis in breast cancer cells via PI3K/Akt/NF-κB-mediated MMP-9 and IL-8 signalling pathways.

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