Abstract A125: Fragment-based approach to develop small-molecule STAT3 transcription factor inhibitors

2018 ◽  
Author(s):  
Kazi S. Nahar ◽  
Shirin Jamshidi ◽  
David E. Thurston ◽  
Khondaker Miraz Rahman
Keyword(s):  
Transcription Factor ◽  
Small Molecule ◽  
Stat3 Transcription Factor

Abstract 1624: A fragment-based approach to the development of small-molecule STAT3 transcription factor inhibitors

2014 ◽  
Author(s):  
Kazi Sharmin Nahar ◽  
Christopher Chamberlain ◽  
Aanchal Grover ◽  
Paul Jackson ◽  
Khondaker M. Rahman ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Small Molecule ◽  
Stat3 Transcription Factor

Inhibition of NGLY1 inactivates the transcription factor Nrf1 and potentiates proteasome inhibitor cytotoxicity

2017 ◽  
Author(s):  
Carolyn Bertozzi ◽  
Fred Tomlin ◽  
Ulla Gerling-Driessen ◽  
Yi-Chang Liu ◽  
Ryan Flynn ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Small Molecule ◽  
Proteasome Inhibitor ◽  
Activation Mechanism ◽  
Cancer Drugs ◽  
Small Molecule Library ◽  
Library Screen ◽  
In Cells

We discovered that the proteostasis modulating transcription factor Nrf1 requires cytosolic de-N-glycosylation by the N-glycanase NGly1 as part of its activation mechanism. Through a covalent small molecule library screen, we discovered an inhibitor of NGly1 that blocks Nrf1 activation in cells and potentiates the activity of proteasome inhibitor cancer drugs. The requirement of NGly1 for Nrf1 activity likely underlies several pathologies associated with a rare hereditary deficiency in NGly1.

Cellular dynamics of the STAT3 transcription factor

Cytokine ◽  
2009 ◽  
Vol 48 (1-2) ◽  
pp. 127
Author(s):  
Velasco Cimica ◽  
Janaki Iyer ◽  
Nancy C. Reich
Keyword(s):  
Transcription Factor ◽  
Cellular Dynamics ◽  
Stat3 Transcription Factor

scholarly journals Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor

2018 ◽  
Vol 19 (6) ◽  
pp. 1608 ◽  
Author(s):  
David Lee ◽  
Rachel O’Keefe ◽  
Patrick Ha ◽  
Jennifer Grandis ◽  
Daniel Johnson
Keyword(s):  
Transcription Factor ◽  
Biochemical Properties ◽  
Stat3 Transcription Factor

scholarly journals Corrigendum to: “Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers” [EBioMedicine 8 (2016) 117–131]

EBioMedicine ◽  
2017 ◽  
Vol 25 ◽  
pp. 188
Author(s):  
Anuradha Illendula ◽  
Jane Gilmour ◽  
Jolanta Grembecka ◽  
Venkata Sesha Srimath Tirumala ◽  
Adam Boulton ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Molecule Inhibitor

QD-FRET-based biosensing of small molecule analytes using transcription factor-DNA binding

2019 ◽  
Author(s):  
Thuy Nguyen ◽  
Margaret Chern ◽  
R C. Baer ◽  
Andy Fan ◽  
Chloe Grazon ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Dna Binding ◽  
Small Molecule
Sign in / Sign up

Export Citation Format

Share Document