Abstract 3242: New chemical tools for disrupting the MDM2/p53 protein-protein interaction: Identification, synthesis and biological evaluation of a novel class of MDM2/p53 inhibitors

2011 ◽  
Author(s):  
Daniele Pernazza ◽  
Xiaolong Li ◽  
Harshani R. Lawrence ◽  
Wayne C. Guida ◽  
Courtney J. DuBoulay ◽  
...  
Keyword(s):  
Protein Interaction ◽  
P53 Protein ◽  
Biological Evaluation ◽  
Protein Protein Interaction ◽  
Chemical Tools ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK–VEGFR3 protein–protein interaction

2014 ◽  
Vol 80 ◽  
pp. 154-166 ◽  
Author(s):  
Priyanka N. Gogate ◽  
Manivannan Ethirajan ◽  
Elena V. Kurenova ◽  
Andrew T. Magis ◽  
Ravindra K. Pandey ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Protein Protein Interaction ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of thielocin B1 analogues as protein-protein interaction inhibitors of PAC3 homodimer

2018 ◽  
Vol 26 (23-24) ◽  
pp. 6023-6034 ◽  
Author(s):  
Kosuke Ohsawa ◽  
Masahito Yoshida ◽  
Miho Izumikawa ◽  
Motoki Takagi ◽  
Kazuo Shin-ya ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Biological Evaluation ◽  
Protein Protein Interaction ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of novel antiviral agents as protein–protein interaction inhibitors

2013 ◽  
Vol 29 (2) ◽  
pp. 237-242 ◽  
Author(s):  
Stefania Ferro ◽  
Laura De Luca ◽  
Francesca Morreale ◽  
Frauke Christ ◽  
Zeger Debyser ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Antiviral Agents ◽  
Biological Evaluation ◽  
Protein Protein Interaction ◽  
Synthesis And Biological Evaluation

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

2021 ◽  
Author(s):  
Gianni Chessari ◽  
Ian R. Hardcastle ◽  
Jong Sook Ahn ◽  
Burcu Anil ◽  
Elizabeth Anscombe ◽  
...  
Keyword(s):  
Protein Interaction ◽  
P53 Protein ◽  
Protein Protein Interaction ◽  
Orally Active

MDM2-p53 protein–protein interaction inhibitors: A-ring substituted isoindolinones

2011 ◽  
Author(s):  
Anna F. Watson ◽  
Junfeng Liu ◽  
Karim Bennaceur ◽  
Catherine J. Drummond ◽  
Jane A. Endicott ◽  
...  
Keyword(s):  
Protein Interaction ◽  
P53 Protein ◽  
Protein Protein Interaction
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