Abstract 828: Design, synthesis and biological evaluation of peptide inhibitors of the Keap1-Nrf2 protein-protein interaction

2011 ◽  
Author(s):  
Rowena Hancock ◽  
Helene Bertrand ◽  
Shama Naz ◽  
Tadayuki Tsujita ◽  
John Hayes ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Biological Evaluation ◽  
Peptide Inhibitors ◽  
Design Synthesis ◽  
Protein Protein Interaction ◽  
Synthesis And Biological Evaluation ◽  
Nrf2 Protein

scholarly journals Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK–VEGFR3 protein–protein interaction

2014 ◽  
Vol 80 ◽  
pp. 154-166 ◽  
Author(s):  
Priyanka N. Gogate ◽  
Manivannan Ethirajan ◽  
Elena V. Kurenova ◽  
Andrew T. Magis ◽  
Ravindra K. Pandey ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Protein Protein Interaction ◽  
Synthesis And Biological Evaluation

scholarly journals Modified Peptide Inhibitors of the Keap1–Nrf2 Protein–Protein Interaction Incorporating Unnatural Amino Acids

ChemBioChem ◽  
2018 ◽  
Vol 19 (17) ◽  
pp. 1810-1816 ◽  
Author(s):  
Nikolaos D. Georgakopoulos ◽  
Sandeep K. Talapatra ◽  
Jemma Gatliff ◽  
Frank Kozielski ◽  
Geoff Wells
Keyword(s):  
Amino Acids ◽  
Protein Interaction ◽  
Unnatural Amino Acids ◽  
Peptide Inhibitors ◽  
Protein Protein Interaction ◽  
Nrf2 Protein

Binding thermodynamics and kinetics guided optimization of potent Keap1–Nrf2 peptide inhibitors

RSC Advances ◽  
2015 ◽  
Vol 5 (105) ◽  
pp. 85983-85987 ◽  
Author(s):  
Meng-Chen Lu ◽  
Zhi-Yun Chen ◽  
Ya-Lou Wang ◽  
Yong-Lin Jiang ◽  
Zhen-Wei Yuan ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Peptide Inhibitors ◽  
Research Interest ◽  
Novel Agents ◽  
Binding Thermodynamics ◽  
Protein Protein Interaction ◽  
Thermodynamics And Kinetics ◽  
Nrf2 Protein

Activation of Nrf2 by directly inhibiting the Keap1–Nrf2 Protein–Protein Interaction (PPI) has gained research interest with regard to developing novel agents for treating inflammatory related diseases.

Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction

2020 ◽  
Vol 28 (21) ◽  
pp. 115738
Author(s):  
Stefania Colarusso ◽  
Daniele De Simone ◽  
Tommaso Frattarelli ◽  
Matteo Andreini ◽  
Mauro Cerretani ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Cyclic Peptide ◽  
Peptide Inhibitors ◽  
Protein Protein Interaction ◽  
Nrf2 Protein

Peptide inhibitors of the Keap1–Nrf2 protein–protein interaction

2012 ◽  
Vol 52 (2) ◽  
pp. 444-451 ◽  
Author(s):  
Rowena Hancock ◽  
Hélène C. Bertrand ◽  
Tadayuki Tsujita ◽  
Shama Naz ◽  
Ayman El-Bakry ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Peptide Inhibitors ◽  
Protein Protein Interaction ◽  
Nrf2 Protein

scholarly journals Design, synthesis, and biological evaluation of novel selective peptide inhibitors of 11β-hydroxysteroid dehydrogenase 1

2018 ◽  
Vol 26 (18) ◽  
pp. 5128-5139
Author(s):  
Stephanie Boudon ◽  
Marc Heidl ◽  
Anna Vuorinen ◽  
Eliane Wandeler ◽  
Remo Campiche ◽  
...  
Keyword(s):  
Hydroxysteroid Dehydrogenase ◽  
Biological Evaluation ◽  
Peptide Inhibitors ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
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