Abstract 4092: Identifying the role of TGFβ in osteogenic prostate cancer to bone metastases; an integrated biological/mathematical modeling study.

2013 ◽  
Author(s):  
Leah M. Cook ◽  
Arturo Araujo ◽  
David Basanta ◽  
Conor C. Lynch
Keyword(s):  
Mathematical Modeling ◽  
Prostate Cancer ◽  
Bone Metastases ◽  
Modeling Study

Prostate Cancer: Role of SPECT and PET in Imaging Bone Metastases

2009 ◽  
Vol 39 (6) ◽  
pp. 396-407 ◽  
Author(s):  
Mohsen Beheshti ◽  
Werner Langsteger ◽  
Ignac Fogelman
Keyword(s):  
Prostate Cancer ◽  
Bone Metastases

Advances in prevention and treatment of bone metastases in prostate cancer. Role of RANK/RANKL inhibition

2013 ◽  
Vol 37 (5) ◽  
pp. 292-304 ◽  
Author(s):  
F. Gomez-Veiga ◽  
J. Ponce-Reixa ◽  
S. Martinez-Breijo ◽  
J. Planas ◽  
J. Morote
Keyword(s):  
Prostate Cancer ◽  
Bone Metastases ◽  
Prevention And Treatment

scholarly journals Fibroblast growth factors signaling in bone metastasis

2020 ◽  
Vol 27 (7) ◽  
pp. R255-R265
Author(s):  
Estefania Labanca ◽  
Elba S Vazquez ◽  
Paul G Corn ◽  
Justin M Roberts ◽  
Fen Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastases ◽  
Cancer Progression ◽  
Cell Communication ◽  
Fibroblast Growth Factors ◽  
Bone Biology ◽  
Signaling Axis ◽  
Basic Concepts ◽  
Adult Bone

Many solid tumors metastasize to bone, but only prostate cancer has bone as a single, dominant metastatic site. Recently, the FGF axis has been implicated in cancer progression in some tumors and mounting evidence indicate that it mediates prostate cancer bone metastases. The FGF axis has an important role in bone biology and mediates cell-to-cell communication. Therefore, we discuss here basic concepts of bone biology, FGF signaling axis, and FGF axis function in adult bone, to integrate these concepts in our current understanding of the role of FGF axis in bone metastases.

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