Abstract 645: DNA methylation marker discovery for the prediction of nodal metastases in head and neck cancer.

2013 ◽  
Author(s):  
Martijn Clausen ◽  
Lieuwe J. Melchers ◽  
Leonie Bruine de Bruin ◽  
Mirjam F. Mastik ◽  
Lorian Slagter-Menkema ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Nodal Metastases ◽  
Methylation Marker ◽  
Marker Discovery

scholarly journals Salivary DNA Methylation as an Epigenetic Biomarker for Head and Neck Cancer. Part I: A Diagnostic Accuracy Meta-Analysis

2021 ◽  
Vol 11 (6) ◽  
pp. 568
Author(s):  
Óscar Rapado-González ◽  
Cristina Martínez-Reglero ◽  
Ángel Salgado-Barreira ◽  
Laura Muinelo-Romay ◽  
Juan Muinelo-Lorenzo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Diagnostic Accuracy ◽  
Head And Neck ◽  
Likelihood Ratio ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Positive Likelihood Ratio ◽  
Epigenetic Mechanism ◽  
Cochrane Library

DNA hypermethylation is an important epigenetic mechanism for gene expression inactivation in head and neck cancer (HNC). Saliva has emerged as a novel liquid biopsy representing a potential source of biomarkers. We performed a comprehensive meta-analysis to evaluate the overall diagnostic accuracy of salivary DNA methylation for detecting HNC. PubMed EMBASE, Web of Science, LILACS, and the Cochrane Library were searched. Study quality was assessed by the Quality Assessment for Studies of Diagnostic Accuracy-2, and sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (dOR), and their corresponding 95% confidence intervals (CIs) were calculated using a bivariate random-effect meta-analysis model. Meta-regression and subgroup analyses were performed to assess heterogeneity. Eighty-four study units from 18 articles with 8368 subjects were included. The pooled sensitivity and specificity of salivary DNA methylation were 0.39 and 0.87, respectively, while PLR and NLR were 3.68 and 0.63, respectively. The overall area under the curve (AUC) was 0.81 and the dOR was 8.34. The combination of methylated genes showed higher diagnostic accuracy (AUC, 0.92 and dOR, 36.97) than individual gene analysis (AUC, 0.77 and dOR, 6.02). These findings provide evidence regarding the potential clinical application of salivary DNA methylation for HNC diagnosis.

scholarly journals JAK3 Variant, Immune Signatures, DNA Methylation, and Social Determinants Linked to Survival Racial Disparities in Head and Neck Cancer Patients

2019 ◽  
Vol 12 (4) ◽  
pp. 255-270 ◽  
Author(s):  
Rafael Guerrero-Preston ◽  
Fahcina Lawson ◽  
Sebastian Rodriguez-Torres ◽  
Maartje G. Noordhuis ◽  
Francesca Pirini ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Racial Disparities ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Social Determinants ◽  
Immune Signatures

scholarly journals Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer

2020 ◽  
Vol 21 (12) ◽  
pp. 3751-3759
Author(s):  
Tialfi Bergamin de Castro ◽  
Gabriela Rodrigues-Fleming ◽  
Juliana Oliveira-Cucolo ◽  
Jéssika Nunes Silva ◽  
Fabia Silva ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Gene Polymorphisms ◽  
Folate Metabolism

scholarly journals Overall Neutrophil-to-Lymphocyte Ratio and SUVmax of Nodal Metastases Predict Outcome in Head and Neck Cancer Before Chemoradiation

2021 ◽  
Vol 11 ◽  
Author(s):  
Jonas Werner ◽  
Klaus Strobel ◽  
Dirk Lehnick ◽  
Gunesh P. Rajan
Keyword(s):  
Head And Neck Cancer ◽  
Lymph Node ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Primary Tumor ◽  
Nodal Metastases ◽  
Metabolic Markers ◽  
Node Metastases ◽  
Fdg Pet Ct

IntroductionThis study investigates the pretherapeutic neutrophil-to-lymphocyte ratio (NLR) with markers of tumor metabolism in 18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and their potential prognostic value in head and neck cancer patients prior to primary chemoradiation.Materials and MethodsNLR and metabolic markers of primary tumor and nodal metastases including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were retrospectively assessed in a consecutive cohort of head and neck squamous cell cancer patients undergoing primary chemoradiation. The main outcome measure was survival.ResultsThe study included 90 patients of which 74 had lymph node metastases at diagnosis. Median follow-up time of nodal positive patients (n=74) was 26.5 months (IQR 18–44). The NLR correlated significantly with metabolic markers of the primary tumor (TLG: rs=0.47, P<0.001; MTV: rs=0.40, P<0.001; SUVmax: rs=0.34, P=0.003), but much less with FDG-PET/CT surrogate markers of metabolic activity in nodal metastases (TLG: rs=0.15, P=0.19; MTV: rs=0.25, P=0.034; SUVmax: rs=0.06, P=0.63). For nodal positive cancer patients, multivariate analysis showed that an increased NLR (HR=1.19, 95% CI=1.04-1.37, P=0.012) and SUVmax of lymph node metastasis (HR=1.09; 95% CI=0.99-1.19; P=0.081) are independently predictive of disease-specific survival. High NLR had a negative prognostic value for overall survival (HR=1.16, 95% CI=1.02-1.33, P=0.021).ConclusionNLR correlates positively with metabolic markers of the primary tumor, suggestive of an unspecific inflammatory response in the host as a possible reflection of increased metabolism of the primary tumor. SUVmax of lymph node metastases and the NLR, however, show no correlation and are independently predictive of disease-specific survival. Therefore, their addition could be used to improve survival prediction in nodal positive head and neck cancer patients undergoing primary chemoradiation.

scholarly journals Lymphatic Vessel Density, Nodal Metastases, and Prognosis in Patients With Head and Neck Cancer

2005 ◽  
Vol 131 (12) ◽  
pp. 1065 ◽  
Author(s):  
Nathalie Audet ◽  
Nigel J. Beasley ◽  
Christina MacMillan ◽  
David G. Jackson ◽  
Patrick J. Gullane ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Lymphatic Vessel ◽  
Vessel Density ◽  
Lymphatic Vessel Density ◽  
Nodal Metastases

scholarly journals Outlier Analysis Defines Zinc Finger Gene Family DNA Methylation in Tumors and Saliva of Head and Neck Cancer Patients

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142148 ◽  
Author(s):  
Daria A. Gaykalova ◽  
Rajita Vatapalli ◽  
Yingying Wei ◽  
Hua-Ling Tsai ◽  
Hao Wang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Gene Family ◽  
Head And Neck ◽  
Cancer Patients ◽  
Zinc Finger ◽  
Neck Cancer ◽  
Outlier Analysis ◽  
Zinc Finger Gene
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