scholarly journals DNA Methylation in the Pathogenesis of Head and Neck Cancer

10.5772/51169 ◽  
2012 ◽  
Author(s):  
Zvonko Magic ◽  
Gordana Supic ◽  
Mirjana Brankovic-Magic ◽  
Nebojsa Jovic
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer

scholarly journals Salivary DNA Methylation as an Epigenetic Biomarker for Head and Neck Cancer. Part I: A Diagnostic Accuracy Meta-Analysis

2021 ◽  
Vol 11 (6) ◽  
pp. 568
Author(s):  
Óscar Rapado-González ◽  
Cristina Martínez-Reglero ◽  
Ángel Salgado-Barreira ◽  
Laura Muinelo-Romay ◽  
Juan Muinelo-Lorenzo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Diagnostic Accuracy ◽  
Head And Neck ◽  
Likelihood Ratio ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Positive Likelihood Ratio ◽  
Epigenetic Mechanism ◽  
Cochrane Library

DNA hypermethylation is an important epigenetic mechanism for gene expression inactivation in head and neck cancer (HNC). Saliva has emerged as a novel liquid biopsy representing a potential source of biomarkers. We performed a comprehensive meta-analysis to evaluate the overall diagnostic accuracy of salivary DNA methylation for detecting HNC. PubMed EMBASE, Web of Science, LILACS, and the Cochrane Library were searched. Study quality was assessed by the Quality Assessment for Studies of Diagnostic Accuracy-2, and sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (dOR), and their corresponding 95% confidence intervals (CIs) were calculated using a bivariate random-effect meta-analysis model. Meta-regression and subgroup analyses were performed to assess heterogeneity. Eighty-four study units from 18 articles with 8368 subjects were included. The pooled sensitivity and specificity of salivary DNA methylation were 0.39 and 0.87, respectively, while PLR and NLR were 3.68 and 0.63, respectively. The overall area under the curve (AUC) was 0.81 and the dOR was 8.34. The combination of methylated genes showed higher diagnostic accuracy (AUC, 0.92 and dOR, 36.97) than individual gene analysis (AUC, 0.77 and dOR, 6.02). These findings provide evidence regarding the potential clinical application of salivary DNA methylation for HNC diagnosis.

scholarly journals JAK3 Variant, Immune Signatures, DNA Methylation, and Social Determinants Linked to Survival Racial Disparities in Head and Neck Cancer Patients

2019 ◽  
Vol 12 (4) ◽  
pp. 255-270 ◽  
Author(s):  
Rafael Guerrero-Preston ◽  
Fahcina Lawson ◽  
Sebastian Rodriguez-Torres ◽  
Maartje G. Noordhuis ◽  
Francesca Pirini ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Racial Disparities ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Social Determinants ◽  
Immune Signatures

Abstract 645: DNA methylation marker discovery for the prediction of nodal metastases in head and neck cancer.

2013 ◽  
Author(s):  
Martijn Clausen ◽  
Lieuwe J. Melchers ◽  
Leonie Bruine de Bruin ◽  
Mirjam F. Mastik ◽  
Lorian Slagter-Menkema ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Nodal Metastases ◽  
Methylation Marker ◽  
Marker Discovery

scholarly journals Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer

2020 ◽  
Vol 21 (12) ◽  
pp. 3751-3759
Author(s):  
Tialfi Bergamin de Castro ◽  
Gabriela Rodrigues-Fleming ◽  
Juliana Oliveira-Cucolo ◽  
Jéssika Nunes Silva ◽  
Fabia Silva ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Gene Polymorphisms ◽  
Folate Metabolism

scholarly journals Outlier Analysis Defines Zinc Finger Gene Family DNA Methylation in Tumors and Saliva of Head and Neck Cancer Patients

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142148 ◽  
Author(s):  
Daria A. Gaykalova ◽  
Rajita Vatapalli ◽  
Yingying Wei ◽  
Hua-Ling Tsai ◽  
Hao Wang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Gene Family ◽  
Head And Neck ◽  
Cancer Patients ◽  
Zinc Finger ◽  
Neck Cancer ◽  
Outlier Analysis ◽  
Zinc Finger Gene

scholarly journals Diagnostic accuracy of DNA methylation for head and neck cancer varies by sample type and number of markers tested

Oncotarget ◽  
2016 ◽  
Vol 7 (48) ◽  
pp. 80019-80032 ◽  
Author(s):  
Xu Ji ◽  
Chao Guan ◽  
Xuejun Jiang ◽  
Hong Li
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Diagnostic Accuracy ◽  
Head And Neck ◽  
Neck Cancer ◽  
Sample Type

scholarly journals Epigenetic stratification of head and neck cancer survivors reveals differences in lycopene levels, alcohol consumption, and methylation of immune regulatory genes

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Laura Moody ◽  
Sylvia L. Crowder ◽  
Andrew D. Fruge ◽  
Julie L. Locher ◽  
Wendy Demark-Wahnefried ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Alcohol Consumption ◽  
Head And Neck ◽  
Signaling Pathway ◽  
Neck Cancer ◽  
Cell Receptor ◽  
Receptor Signaling ◽  
Treatment Type ◽  
Cell Receptor Signaling

Abstract Background Inflammation has been associated with higher rates of recurrence and mortality in head and neck cancer (HNC). While the biological mechanisms predisposing patients to heightened inflammatory states remain largely unknown, DNA methylation has been proposed to reflect systemic inflammation. In this analysis, we attempt to identify meaningful epigenetic patterns in HNC survivors by stratifying individuals based on DNA methylation profiles in leukocytes. Results We used hierarchical clustering to uncover three distinct methylation patterns among HNC survivors. Each group displayed a unique methylation signature in inflammatory pathways including cytokine and B-cell receptor signaling. Additionally, we examined physiological, clinical, and lifestyle parameters related to inflammation, such as circulating carotenoid and cytokine levels, cancer treatment type, and alcohol consumption. Specifically, we identified one group of survivors who had significant differential methylation of transcriptional and translational regulators as well as genes in the T-cell receptor signaling pathway, including hypermethylation of CD40 ligand (CD40LG) and Tec protein tyrosine kinase (TEC) and hypomethylation of CD8A. This group also displayed high circulating lycopene levels. We identified another group that had distinctive methylation in the toll-like receptor (TLR) signaling pathway, including hypomethylation of TLR5, a component of the inhibitor of nuclear factor-kappa B kinase complex (CHUK), and two mitogen-activated protein kinases (MAP3K8 and MAP2K3). This group also had hypermethylation of mitochondrial ribosomal genes along with higher rates of alcohol consumption. Conclusion The correlation between lycopene, alcohol consumption, DNA methylation, and inflammation warrants further investigation and may have implications in future recommendations and interventions to impact health outcomes in HNC survivors.

scholarly journals Global Genome Demethylation Causes Transcription-Associated DNA Double Strand Breaks in HPV-Associated Head and Neck Cancer Cells

Cancers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 21
Author(s):  
Michael Hajek ◽  
Asel Biktasova ◽  
Andrew Sewell ◽  
Cyril Gary ◽  
Paul Cantalupo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Transcriptional Repression ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Active Transcription

High levels of DNA methylation at CpG loci are associated with transcriptional repression of tumor suppressor genes and dysregulation of DNA repair genes. Human papilloma virus (HPV)-associated head and neck squamous cell carcinomas (HNSCC) have high levels of DNA methylation and methylation has been associated with dampening of an innate immune response in virally infected cells. We have been exploring demethylation as a potential treatment in HPV+ HNSCC and recently reported results of a window clinical trial showing that HNSCCs are particularly sensitive to demethylating agent 5-azacytidine (5-aza). Mechanistically, sensitivity is partially due to downregulation of HPV genes expression and restoration of tumor suppressors p53 and Rb. Here, for the first time, we show that 5-azaC treatment of HPV+ HNSCC induces replication and transcription-associated DNA double strand breaks (DSBs) that occur preferentially at demethylated genomic DNA. Blocking replication or transcription prevented formation of DNA DSBs and reduced sensitivity of HPV-positive head and neck cancer cells to 5-azaC, demonstrating that both replication and active transcription are required for formation of DSBs associated with 5-azaC.

scholarly journals DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival

Oral Oncology ◽  
2018 ◽  
Vol 85 ◽  
pp. 87-94 ◽  
Author(s):  
Srikant Ambatipudi ◽  
Ryan Langdon ◽  
Rebecca C. Richmond ◽  
Matthew Suderman ◽  
Devin C. Koestler ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Systemic Inflammation ◽  
Neck Cancer ◽  
Cancer Development
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