Abstract 4629: Physiologically based pharmacokinetic model and correlative in vitro assessment of metabolism-based interaction between Everolimus and PI3K/mTOR inhibitor BEZ235

Mapping Intimacies ◽

10.1158/1538-7445.am2014-4629 ◽

2014 ◽

Author(s):

Ganesh P. Moorthy ◽

Bilal Abuasal ◽

Larry Sallans ◽

John C. Morris ◽

George Thomas ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Mtor Inhibitor ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vitro Assessment

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The Novel In Vitro Method to Calculate Tissue-to-Plasma Partition Coefficient in Humans for Predicting Pharmacokinetic Profiles by Physiologically-Based Pharmacokinetic Model With High Predictability

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2020.04.002 ◽

2020 ◽

Vol 109 (7) ◽

pp. 2345-2355

Author(s):

Kei Mayumi ◽

Miho Tachibana ◽

Mei Yoshida ◽

Shuichi Ohnishi ◽

Takushi Kanazu ◽

...

Keyword(s):

Pharmacokinetic Model ◽

The Novel ◽

Physiologically Based Pharmacokinetic Model ◽

In Vitro Method ◽

Physiologically Based Pharmacokinetic ◽

Pharmacokinetic Profiles ◽

Physiologically Based ◽

High Predictability ◽

Plasma Partition Coefficient

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Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data

Drug Metabolism and Disposition ◽

10.1124/dmd.112.050294 ◽

2013 ◽

Vol 41 (4) ◽

pp. 744-753 ◽

Author(s):

Katherine L. Gill ◽

Michael Gertz ◽

J. Brian Houston ◽

Aleksandra Galetin

Keyword(s):

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Evaluation of an integrated in vitro–in silico PBPK (physiologically based pharmacokinetic) model to provide estimates of human bioavailability

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2005.11.002 ◽

2006 ◽

Vol 308 (1-2) ◽

pp. 133-139 ◽

Author(s):

Hongliang Cai ◽

Chad Stoner ◽

Anita Reddy ◽

Sascha Freiwald ◽

Danielle Smith ◽

...

Keyword(s):

In Silico ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Simulation of Toluene Kinetics in the Rat by a Physiologically Based Pharmacokinetic Model with Application of Biotransformation Parameters Derived Independently in Vitro and in Vivo

Toxicological Sciences ◽

10.1093/toxsci/32.2.260 ◽

1996 ◽

Vol 32 (2) ◽

pp. 260-268

Author(s):

JOOST DEJONGH ◽

BAS J. BLAAUBOER

Keyword(s):

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Development of a Physiologically Based Pharmacokinetic Model for Sinogliatin, a First-in-Class Glucokinase Activator, by Integrating Allometric Scaling, In Vitro to In Vivo Exploration and Steady-State Concentration–Mean Residence Time Methods: Mechanistic Understanding of its Pharmacokinetics

Clinical Pharmacokinetics ◽

10.1007/s40262-018-0631-z ◽

2018 ◽

Vol 57 (10) ◽

pp. 1307-1323 ◽

Author(s):

Ling Song ◽

Yi Zhang ◽

Ji Jiang ◽

Shuang Ren ◽

Li Chen ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Allometric Scaling ◽

Physiologically Based Pharmacokinetic Model ◽

Steady State Concentration ◽

Glucokinase Activator ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

State Concentration

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Combining an In Vitro Kinetic Model with a Physiologically-Based Pharmacokinetic Model to Assess the Potential In Vivo Fate of Polyvinyl Pyrrolidone-Vinyl Acetate Copolymers

Pharmaceutical Research ◽

10.1007/s11095-017-2305-1 ◽

2018 ◽

Vol 35 (4) ◽

Author(s):

Daniel S. Hsieh ◽

Liang Luo ◽

Yan Xu ◽

Joshua D. Engstrom ◽

Qi Gao

Keyword(s):

Kinetic Model ◽

Vinyl Acetate ◽

Pharmacokinetic Model ◽

Polyvinyl Pyrrolidone ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Biopharmaceutic In Vitro In Vivo Extrapolation (IVIV_E) Informed Physiologically-Based Pharmacokinetic Model of Ritonavir Norvir Tablet Absorption in Humans Under Fasted and Fed State Conditions

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.0c00043 ◽

2020 ◽

Vol 17 (7) ◽

pp. 2329-2344 ◽

Author(s):

Sumit Arora ◽

Amita Pansari ◽

Peter Kilford ◽

Masoud Jamei ◽

Iain Gardner ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Fed State ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vivo Extrapolation

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A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12461 ◽

2019 ◽

Vol 8 (10) ◽

pp. 738-747 ◽

Author(s):

Hannah M. Jones ◽

Zhiwei Zhang ◽

Paul Jasper ◽

Haobin Luo ◽

Lindsay B. Avery ◽

...

Keyword(s):

Monoclonal Antibody ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Antibody Pharmacokinetics ◽

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Reduced Physiologically-Based Pharmacokinetic Model of Repaglinide: Impact of OATP1B1 and CYP2C8 Genotype and Source of In Vitro Data on the Prediction of Drug-Drug Interaction Risk

Pharmaceutical Research ◽

10.1007/s11095-014-1333-3 ◽

2014 ◽

Vol 31 (9) ◽

pp. 2367-2382 ◽

Author(s):

Michael Gertz ◽

Nikolaos Tsamandouras ◽

Carolina Säll ◽

J. Brian Houston ◽

Aleksandra Galetin

Keyword(s):

Drug Interaction ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction ◽

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Physiologically Based Pharmacokinetic Model for Tetrachlorobenzyltoluenes in Rat: Comparison of in Vitro and in Vivo Metabolic Rates

Toxicological Sciences ◽

10.1093/toxsci/63.1.22 ◽

2001 ◽

Vol 63 (1) ◽

pp. 22-28 ◽

Author(s):

H. J. Kramer

Keyword(s):

Pharmacokinetic Model ◽

Metabolic Rates ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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