Biopharmaceutic In Vitro In Vivo Extrapolation (IVIV_E) Informed Physiologically-Based Pharmacokinetic Model of Ritonavir Norvir Tablet Absorption in Humans Under Fasted and Fed State Conditions

Fed State ◽

Physiologically Based ◽

In Vivo Extrapolation

Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data

Drug Metabolism and Disposition ◽

10.1124/dmd.112.050294 ◽

2013 ◽

Vol 41 (4) ◽

pp. 744-753 ◽

Cited By ~ 15

Author(s):

Katherine L. Gill ◽

Michael Gertz ◽

J. Brian Houston ◽

Aleksandra Galetin

Keyword(s):

Pharmacokinetic Model ◽

Evaluation of Age-Related Pyrethroid Pharmacokinetic Differences in Rats: Physiologically-Based Pharmacokinetic Model Development Using In Vitro Data and In Vitro to In Vivo Extrapolation

Toxicological Sciences ◽

10.1093/toxsci/kfz042 ◽

2019 ◽

Vol 169 (2) ◽

pp. 365-379 ◽

Cited By ~ 9

Author(s):

Gina Song ◽

Marjory Moreau ◽

Alina Efremenko ◽

Brian G Lake ◽

Huali Wu ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Age Related ◽

Physiologically Based ◽

In Vivo Extrapolation ◽

Vitro Data ◽

In Vitro Data

Simulation of Toluene Kinetics in the Rat by a Physiologically Based Pharmacokinetic Model with Application of Biotransformation Parameters Derived Independently in Vitro and in Vivo

Toxicological Sciences ◽

10.1093/toxsci/32.2.260 ◽

1996 ◽

Vol 32 (2) ◽

pp. 260-268

Author(s):

JOOST DEJONGH ◽

BAS J. BLAAUBOER

Keyword(s):

Pharmacokinetic Model ◽

Development of a Physiologically Based Pharmacokinetic Model for Sinogliatin, a First-in-Class Glucokinase Activator, by Integrating Allometric Scaling, In Vitro to In Vivo Exploration and Steady-State Concentration–Mean Residence Time Methods: Mechanistic Understanding of its Pharmacokinetics

Clinical Pharmacokinetics ◽

10.1007/s40262-018-0631-z ◽

2018 ◽

Vol 57 (10) ◽

pp. 1307-1323 ◽

Cited By ~ 4

Author(s):

Ling Song ◽

Yi Zhang ◽

Ji Jiang ◽

Shuang Ren ◽

Li Chen ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Allometric Scaling ◽

Steady State Concentration ◽

Glucokinase Activator ◽

Physiologically Based ◽

State Concentration

Combining an In Vitro Kinetic Model with a Physiologically-Based Pharmacokinetic Model to Assess the Potential In Vivo Fate of Polyvinyl Pyrrolidone-Vinyl Acetate Copolymers

Pharmaceutical Research ◽

10.1007/s11095-017-2305-1 ◽

2018 ◽

Vol 35 (4) ◽

Author(s):

Daniel S. Hsieh ◽

Liang Luo ◽

Yan Xu ◽

Joshua D. Engstrom ◽

Qi Gao

Keyword(s):

Kinetic Model ◽

Vinyl Acetate ◽

Pharmacokinetic Model ◽

Polyvinyl Pyrrolidone ◽

Physiologically Based Pharmacokinetic Model for Tetrachlorobenzyltoluenes in Rat: Comparison of in Vitro and in Vivo Metabolic Rates

Toxicological Sciences ◽

10.1093/toxsci/63.1.22 ◽

2001 ◽

Vol 63 (1) ◽

pp. 22-28 ◽

Cited By ~ 9

Author(s):

H. J. Kramer

Keyword(s):

Pharmacokinetic Model ◽

Metabolic Rates ◽

Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat in vivo and in vitro data sets using a simplified physiologically based pharmacokinetic model

The Journal of Toxicological Sciences ◽

10.2131/jts.46.391 ◽

2021 ◽

Vol 46 (9) ◽

pp. 391-399

Author(s):

Mayu Yanagi ◽

Yusuke Kamiya ◽

Norie Murayama ◽

Kaito Banju ◽

Makiko Shimizu ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Pyrrolizidine Alkaloid ◽

Metabolic Profiles ◽

Data Sets ◽

Development of a Physiologically Based Pharmacokinetic Model for the Rat Central Nervous System and Determination of an In Vitro–In Vivo Scaling Methodology for the Blood–Brain Barrier Permeability of Two Transporter Substrates, Morphine and Oxycodone

Journal of Pharmaceutical Sciences ◽

10.1002/jps.23266 ◽

2012 ◽

Vol 101 (11) ◽

pp. 4277-4292 ◽

Cited By ~ 35

Author(s):

Kathryn Ball ◽

François Bouzom ◽

Jean-Michel Scherrmann ◽

Bernard Walther ◽

Xavier Declèves

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Pharmacokinetic Model ◽

Brain Barrier Permeability ◽

Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico–in vivo extrapolation and physiologically-based pharmacokinetic modeling approach

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2012.12.002 ◽

2013 ◽

Vol 67 (3) ◽

pp. 203-213 ◽

Cited By ~ 12

Author(s):

Jonas Malmborg ◽

Bart A. Ploeger

Keyword(s):

In Silico ◽

Human Exposure ◽

Active Drug ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based ◽

In Vivo Extrapolation ◽

Oral Prodrug

In Vitro to In Vivo Extrapolation of Metabolic Rate Constants for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-9 ◽

2016 ◽

pp. 185-210

Author(s):

Gregory L. Kedderis

Keyword(s):

Metabolic Rate ◽

Rate Constants ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based ◽

In Vivo Extrapolation