Abstract 626: BGB324, a selective small molecule inhibitor of receptor tyrosine kinase AXL, abrogates tumor intrinsic and microenvironmental immune suppression and enhances immune checkpoint inhibitor efficacy in lung and mammary adenocarcinoma models

2017 ◽  
Author(s):  
Katarzyna Wnuk-Lipinska ◽  
Kjersti Davidsen ◽  
Magnus Blø ◽  
Agnete Engelsen ◽  
Jing Kang ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Small Molecule ◽  
Receptor Tyrosine Kinase ◽  
Immune Suppression ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitor ◽  
Checkpoint Inhibitor ◽  
Small Molecule Inhibitor ◽  
Mammary Adenocarcinoma ◽  
Molecule Inhibitor

Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase

2006 ◽  
Vol 71 (10) ◽  
pp. 1422-1434 ◽  
Author(s):  
A.G. Ellis ◽  
M.M. Doherty ◽  
F. Walker ◽  
J. Weinstock ◽  
M. Nerrie ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Small Molecule ◽  
Receptor Tyrosine Kinase ◽  
Egf Receptor ◽  
Small Molecule Inhibitor ◽  
Molecule Inhibitor
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