Abstract 2709: Modulation of the tumor-infiltrating lymphocyte population by PARP inhibitor talazoparib in combination with anti-PD1 treatment significantly enhances overall survival in a murine BRCA1-/-breast cancer model

2019 ◽  
Author(s):  
Anya Avrutskaya ◽  
Cordula Tschuch ◽  
Astrid Jensen ◽  
William Durham ◽  
Maycee Robinson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Parp Inhibitor ◽  
Lymphocyte Population ◽  
Cancer Model ◽  
Tumor Infiltrating Lymphocyte ◽  
Breast Cancer Model

scholarly journals Doubling Down on the PI3K-AKT-mTOR Pathway Enhances the Antitumor Efficacy of PARP Inhibitor in Triple Negative Breast Cancer Model beyond BRCA-ness

Neoplasia ◽  
2014 ◽  
Vol 16 (1) ◽  
pp. 43-W19 ◽  
Author(s):  
Pradip De ◽  
Yuling Sun ◽  
Jennifer H. Carlson ◽  
Lori S. Friedman ◽  
Brian R. Leyland-Jones ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Parp Inhibitor ◽  
Mtor Pathway ◽  
Antitumor Efficacy ◽  
Cancer Model ◽  
Breast Cancer Model

scholarly journals LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis

2019 ◽  
Vol 217 (3) ◽  
Author(s):  
Yirong Wang ◽  
Siqi Wu ◽  
Xun Zhu ◽  
Liyuan Zhang ◽  
Jieqiong Deng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cancer Model ◽  
Down Regulation ◽  
Poor Overall Survival ◽  
Mouse Xenograft ◽  
Stat3 Phosphorylation ◽  
Breast Cancer Model

Triple-negative breast cancer (TNBC) is a subtype of breast cancer (BC) with the most aggressive phenotype and poor overall survival. Using bioinformatics tools, we identified LINC00908 encoding a 60–aa polypeptide and differentially expressed in TNBC tissues. We named this endogenously expressed polypeptide ASRPS (a small regulatory peptide of STAT3). ASRPS expression was down-regulated in TNBCs and associated with poor overall survival. We showed that LINC00908 was directly regulated by ERα, which was responsible for the differential down-regulation of LINC00908 in TNBCs. ASRPS directly bound to STAT3 through the coiled coil domain (CCD) and down-regulated STAT3 phosphorylation, which led to reduced expression of VEGF. In human endothelial cells, a mouse xenograft breast cancer model, and a mouse spontaneous BC model, ASRPS expression reduced angiogenesis. In a mouse xenograft breast cancer model, down-regulation of ASRPS promoted tumor growth, and ASRPS acted as an antitumor peptide. We presented strong evidence that LINC00908-encoded polypeptide ASRPS represented a TNBC-specific target for treatment.

scholarly journals Paclitaxel–Hyaluronic NanoConjugates Prolong Overall Survival in a Preclinical Brain Metastases of Breast Cancer Model

2013 ◽  
Vol 12 (11) ◽  
pp. 2389-2399 ◽  
Author(s):  
Rajendar K. Mittapalli ◽  
Xinli Liu ◽  
Chris E. Adkins ◽  
Mohamed I. Nounou ◽  
Kaci A. Bohn ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Brain Metastases ◽  
Cancer Model ◽  
Breast Cancer Model

Lifelong isoflavone exposure and its implications in an experimental breast cancer model

2015 ◽  
Vol 122 (03) ◽  
Author(s):  
FJ Möller ◽  
K Wende ◽  
O Zierau ◽  
MC Bosland ◽  
MH Muders ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Model ◽  
Breast Cancer Model

Systemic Immunotherapy with Micellar Resiquimod–Polymer Conjugates Triggers a Robust Antitumor Response in a Breast Cancer Model

2021 ◽  
pp. 2100008
Author(s):  
Hamilton Kakwere ◽  
Hua Zhang ◽  
Elizabeth S. Ingham ◽  
Marina Nura‐Raie ◽  
Spencer K. Tumbale ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Model ◽  
Antitumor Response ◽  
Polymer Conjugates ◽  
Breast Cancer Model ◽  
Systemic Immunotherapy

scholarly journals Thermal analysis of laser irradiation-gold nanorod combinations at 808 nm, 940 nm, 975 nm and 1064 nm wavelengths in breast cancer model

2021 ◽  
Vol 38 (1) ◽  
pp. 1099-1110
Author(s):  
Leonardo Bianchi ◽  
Rachael Mooney ◽  
Yvonne R. Cornejo ◽  
Emiliano Schena ◽  
Jacob M. Berlin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Thermal Analysis ◽  
Laser Irradiation ◽  
Gold Nanorod ◽  
Cancer Model ◽  
Breast Cancer Model
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