Abstract 3071: VERU-111, a novel orally bioavailable tubulin inhibitor, overcomes taxane resistance in metastatic triple-negative breast cancer

2020 ◽  
Author(s):  
Shanshan Deng ◽  
Raisa I. Krutilina ◽  
Deanna N. Parke ◽  
Hao Chen ◽  
Duane D. Miller ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Tubulin Inhibitor ◽  
Taxane Resistance ◽  
Orally Bioavailable

VERU-111 as an Oral Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer and Evaluation of Novel Tubulin Inhibitors for Cancer Therapy

2020 ◽  
Author(s):  
◽  
Shanshan Deng ◽  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Molecular Subtypes ◽  
Mortality Rates ◽  
Tubulin Inhibitor ◽  
Tubulin Inhibitors ◽  
Clinical Challenge ◽  
Approved Drugs ◽  
Fda Approved Drugs

Triple negative breast cancer (TNBC) has aggressive clinical features strongly associated with poorer overall prognosis and higher mortality rates relative to other molecular subtypes. FDA-approved drugs, such as paclitaxel, are effective in treating TNBC. Yet, treatment failure is commonly observed due to the development of acquired chemoresistance, which remains a clinical challenge for TNBC therapy.

scholarly journals A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Chetan Rane ◽  
William Senapedis ◽  
Erkan Baloglu ◽  
Yosef Landesman ◽  
Marsha Crochiere ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cancer Tumor ◽  
Orally Bioavailable

Identification of new therapeutic leads for triple negative breast cancer subtypes

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
AJ Robles ◽  
L Du ◽  
S Cai ◽  
RH Cichewicz ◽  
SL Mooberry
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Breast Cancer Subtypes ◽  
Cancer Subtypes ◽  
Therapeutic Leads
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