Abstract 5337: Analysis of drug combinations with the PKC inhibitor IDE196 support dual MEK and PKC inhibition as a rational combination in metastatic uveal melanoma

2020 ◽  
Author(s):  
Christian R. Frey ◽  
Marie-Claire Wagle ◽  
Kedar Vaidya ◽  
Julie Hambleton ◽  
Mark Lackner ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Drug Combinations ◽  
Pkc Inhibitor ◽  
Rational Combination

Abstract CT068: A Phase I trial of LXS196, a novel PKC inhibitor for metastatic uveal melanoma

2019 ◽  
Author(s):  
Ellen Kapiteijn ◽  
Matteo Carlino ◽  
Valentina Boni ◽  
Delphine Loirat ◽  
Frank Speetjens ◽  
...  
Keyword(s):  
Phase I ◽  
Uveal Melanoma ◽  
Phase I Trial ◽  
Pkc Inhibitor

Phase I dose-escalation study of the protein kinase C (PKC) inhibitor AEB071 in patients with metastatic uveal melanoma.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 9030-9030 ◽  
Author(s):  
Sophie Piperno-Neumann ◽  
Ellen Kapiteijn ◽  
James M. G. Larkin ◽  
Richard D. Carvajal ◽  
Jason J. Luke ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Phase I ◽  
Uveal Melanoma ◽  
Dose Escalation ◽  
Dose Escalation Study ◽  
Pkc Inhibitor ◽  
Kinase C

Abstract C149: The PKC inhibitor Sotrastaurin selectively inhibits the growth of GNAQ mutant uveal melanoma.

2013 ◽  
Author(s):  
Rosemary Barrett ◽  
Ribo Guo ◽  
Jing Yuan ◽  
Vesselina Cooke ◽  
Anthony Vattay ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Pkc Inhibitor

scholarly journals Preclinical evaluation of drug combinations identifies co-inhibition of Bcl-2/XL/W and MDM2 as a potential therapy in uveal melanoma

2020 ◽  
Vol 126 ◽  
pp. 93-103 ◽  
Author(s):  
Didier Decaudin ◽  
Estelle Frisch Dit Leitz ◽  
Fariba Nemati ◽  
Malcy Tarin ◽  
Adnan Naguez ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Drug Combinations ◽  
Preclinical Evaluation

Abstract CT068: A Phase I trial of LXS196, a novel PKC inhibitor for metastatic uveal melanoma

2019 ◽  
Author(s):  
Ellen Kapiteijn ◽  
Matteo Carlino ◽  
Valentina Boni ◽  
Delphine Loirat ◽  
Frank Speetjens ◽  
...  
Keyword(s):  
Phase I ◽  
Uveal Melanoma ◽  
Phase I Trial ◽  
Pkc Inhibitor

Abstract #1010: Uveal Melanoma Masquerading as A Nontoxic Multinodular Goiter

2015 ◽  
Vol 21 ◽  
pp. 194-195
Author(s):  
Rokshana Thanadar ◽  
Uzma Siddiqui ◽  
Marie Lithgow ◽  
Runhua Hou
Keyword(s):  
Uveal Melanoma ◽  
Multinodular Goiter

Uveal melanoma metastatic risk based on comprehensive genetic testing

2020 ◽  
pp. 178-179
Author(s):  
V.A. Yarovaya ◽  
◽  
A.A. Yarovoy ◽  
A.R. Zaretsky ◽  
L.V. Chudakova ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Uveal Melanoma ◽  
Metastatic Risk
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