Abstract 1901: Diglyceride acyltransferase 1 reprograms lipid metabolism in myeloid-derived suppressor cells and augments immune checkpoints cancer immunotherapy

2021 ◽  
Author(s):  
Adeleye Oluwatosin Adeshakin ◽  
Dehong Yan ◽  
Funmilayo O. Adeshakin ◽  
Lukman O. Afolabi ◽  
Menqgi Zhang ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Cancer Immunotherapy ◽  
Suppressor Cells ◽  
Immune Checkpoints ◽  
Myeloid Derived Suppressor Cells

Targeting myeloid-derived suppressor cells for cancer immunotherapy

2018 ◽  
Vol 67 (8) ◽  
pp. 1181-1195 ◽  
Author(s):  
Yijun Liu ◽  
Guowei Wei ◽  
Wesley A. Cheng ◽  
Zhenyuan Dong ◽  
Han Sun ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells

Low dose gemcitabine-loaded lipid nanocapsules target monocytic myeloid-derived suppressor cells and potentiate cancer immunotherapy

Biomaterials ◽  
2016 ◽  
Vol 96 ◽  
pp. 47-62 ◽  
Author(s):  
Maria Stella Sasso ◽  
Giovanna Lollo ◽  
Marion Pitorre ◽  
Samantha Solito ◽  
Laura Pinton ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Low Dose ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Lipid Nanocapsules

Nanomedicines modulating myeloid-derived suppressor cells for improving cancer immunotherapy

Nano Today ◽  
2021 ◽  
Vol 39 ◽  
pp. 101163
Author(s):  
Xinghang Dai ◽  
Long Ren ◽  
Mengxi Liu ◽  
Hao Cai ◽  
Hu Zhang ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells

scholarly journals Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy

2018 ◽  
Vol 12 (1) ◽  
pp. 455-465 ◽  
Author(s):  
Nobuo Kondoh ◽  
Masako Mizuno-Kamiya ◽  
Eiji Takayama ◽  
Harumi Kawati ◽  
Naoki Umemura ◽  
...  
Keyword(s):  
Immune Suppression ◽  
Suppressor Cells ◽  
Cellular Systems ◽  
Immune Checkpoints ◽  
Cancer Associated Fibroblasts ◽  
Myeloid Derived Suppressor Cells ◽  
Chronic Infections ◽  
Oral Malignancy ◽  
Cellular Components ◽  
Immune Detection

Introduction:In order to survive, cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression.Methodology:During the development of cancer and chronic infections, the immune checkpoints and cellular components including regulatory T cells, myeloid derived suppressor cells and cancer associated fibroblasts are often enhanced as a mechanism of immune subversion and have therefore become very important therapeutic targets.Conclusion:In this review, we will discuss the complexity of immune-suppressive mechanisms in the tumor milieu of cancers, including oral malignancy.

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