Nanoparticle Systems Modulating Myeloid-Derived Suppressor Cells for Cancer Immunotherapy

2017 ◽  
Vol 17 (16) ◽  
pp. 1843-1857 ◽  
Author(s):  
Avia Wilkerson ◽  
Julian Kim ◽  
Alex Y. Huang ◽  
Mei Zhang
Keyword(s):  
Cancer Immunotherapy ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells

Targeting myeloid-derived suppressor cells for cancer immunotherapy

2018 ◽  
Vol 67 (8) ◽  
pp. 1181-1195 ◽  
Author(s):  
Yijun Liu ◽  
Guowei Wei ◽  
Wesley A. Cheng ◽  
Zhenyuan Dong ◽  
Han Sun ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells

Low dose gemcitabine-loaded lipid nanocapsules target monocytic myeloid-derived suppressor cells and potentiate cancer immunotherapy

Biomaterials ◽  
2016 ◽  
Vol 96 ◽  
pp. 47-62 ◽  
Author(s):  
Maria Stella Sasso ◽  
Giovanna Lollo ◽  
Marion Pitorre ◽  
Samantha Solito ◽  
Laura Pinton ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Low Dose ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Lipid Nanocapsules

Nanomedicines modulating myeloid-derived suppressor cells for improving cancer immunotherapy

Nano Today ◽  
2021 ◽  
Vol 39 ◽  
pp. 101163
Author(s):  
Xinghang Dai ◽  
Long Ren ◽  
Mengxi Liu ◽  
Hao Cai ◽  
Hu Zhang ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells

scholarly journals Re-polarizing Myeloid-derived Suppressor Cells (MDSCs) with Cationic Polymers for Cancer Immunotherapy

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Wei He ◽  
Pei Liang ◽  
Guangxing Guo ◽  
Zhen Huang ◽  
Yiming Niu ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Cationic Polymers

scholarly journals Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1170
Author(s):  
Mithunah Krishnamoorthy ◽  
Lara Gerhardt ◽  
Saman Maleki Maleki Vareki
Keyword(s):  
T Cell ◽  
Tumor Growth ◽  
Cancer Immunotherapy ◽  
Tumor Immunity ◽  
Cancer Progression ◽  
Suppressor Cells ◽  
T Cell Immunity ◽  
Myeloid Derived Suppressor Cells ◽  
Cell Immunity ◽  
Promote Tumor Growth

The primary function of myeloid cells is to protect the host from infections. However, during cancer progression or states of chronic inflammation, these cells develop into myeloid-derived suppressor cells (MDSCs) that play a prominent role in suppressing anti-tumor immunity. Overcoming the suppressive effects of MDSCs is a major hurdle in cancer immunotherapy. Therefore, understanding the mechanisms by which MDSCs promote tumor growth is essential for improving current immunotherapies and developing new ones. This review explores mechanisms by which MDSCs suppress T-cell immunity and how this impacts the efficacy of commonly used immunotherapies.

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