Abstract B14: Developing small-molecule inhibitors to the androgen receptor N-terminus domain for the treatment of advanced prostate cancer

Marianne D. Sadar; Jae-Kyung Myung; Iain McEwan; Stephen Plymate; Raymond J. Andersen; Carmen A. Banuelos; Nasrin R. Mawji; Jun Wang; Javier Garcia Fernandez; Amy Tien; Iran Tavakoli; Yu Chi Yang; Simon Haile

doi:10.1158/1538-7445.prca2012-b14

Abstract B14: Developing small-molecule inhibitors to the androgen receptor N-terminus domain for the treatment of advanced prostate cancer

Cancer Research ◽

10.1158/1538-7445.prca2012-b14 ◽

2012 ◽

Vol 72 (4 Supplement) ◽

pp. B14-B14

Author(s):

Marianne D. Sadar ◽

Jae-Kyung Myung ◽

Iain McEwan ◽

Stephen Plymate ◽

Raymond J. Andersen ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Advanced Prostate Cancer ◽

Small Molecule Inhibitors ◽

N Terminus

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Advances in small molecule inhibitors of androgen receptor for the treatment of advanced prostate cancer

World Journal of Urology ◽

10.1007/s00345-011-0745-5 ◽

2011 ◽

Vol 30 (3) ◽

pp. 311-318 ◽

Cited By ~ 17

Author(s):

Marianne D. Sadar

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Advanced Prostate Cancer ◽

Small Molecule Inhibitors

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Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2013.02.056 ◽

2013 ◽

Vol 23 (7) ◽

pp. 1945-1948 ◽

Cited By ~ 30

Author(s):

Robert H. Bradbury ◽

David G. Acton ◽

Nicola L. Broadbent ◽

A. Nigel Brooks ◽

Gregory R. Carr ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Advanced Prostate Cancer

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Abstract LBA016: Androgen Receptor (AR) N-Terminus-Domain-Binding Small Molecule Degraders for the Treatment of AR Splice Variant-Positive Castration-Resistant Prostate Cancer

10.1158/1535-7163.targ-21-lba016 ◽

2021 ◽

Author(s):

Ramesh Narayanan

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Splice Variant ◽

Castration Resistant Prostate Cancer ◽

Castration Resistant ◽

N Terminus

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ChemInform Abstract: Small-Molecule Androgen Receptor Downregulators as an Approach to Treatment of Advanced Prostate Cancer.

ChemInform ◽

10.1002/chin.201202200 ◽

2011 ◽

Vol 43 (2) ◽

pp. no-no

Author(s):

Robert H. Bradbury ◽

et al. et al.

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Advanced Prostate Cancer

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Emerging Non-Canonical Small-Molecule Inhibitors of Androgen Receptor (AR) and AR Interactome Partners for the Treatment of Castrate-Resistant Prostate Cancer

2018 Medicinal Chemistry Reviews - Medicinal Chemistry Reviews ◽

10.29200/acsmedchemrev-v53.ch14 ◽

2018 ◽

pp. 267-288

Author(s):

David B. Freeman ◽

André Ri ◽

Marius S. Pop ◽

Nicholas B. Struntz ◽

Angela N. Ko

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Castrate Resistant Prostate Cancer ◽

Castrate Resistant

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Abstract 2598: Developing small molecule inhibitors that target androgen receptor signaling in castration-resistant prostate cancer

10.1158/1538-7445.sabcs18-2598 ◽

2019 ◽

Author(s):

Balaji Chandrasekaran ◽

Ashish Tyagi ◽

Venkatesh Kolluru ◽

Aakash M. Vadhanam ◽

Becca von Baby ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Receptor Signaling ◽

Castration Resistant Prostate Cancer ◽

Androgen Receptor Signaling ◽

Castration Resistant

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Abstract 2598: Developing small molecule inhibitors that target androgen receptor signaling in castration-resistant prostate cancer

10.1158/1538-7445.am2019-2598 ◽

2019 ◽

Author(s):

Balaji Chandrasekaran ◽

Ashish Tyagi ◽

Venkatesh Kolluru ◽

Aakash M. Vadhanam ◽

Becca von Baby ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Receptor Signaling ◽

Castration Resistant Prostate Cancer ◽

Androgen Receptor Signaling ◽

Castration Resistant

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Abstract 3991: Novel small molecule inhibitors of p300/CBP down-regulate androgen receptor (AR) and c-Myc for the treatment of prostate cancer and beyond

10.1158/1538-7445.am2018-3991 ◽

2018 ◽

Cited By ~ 1

Author(s):

Neil Pegg ◽

Jenny Worthington ◽

Barbara Young ◽

Amy Prosser ◽

Luke Gaughan ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Small Molecule Inhibitors

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Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2011.06.122 ◽

2011 ◽

Vol 21 (18) ◽

pp. 5442-5445 ◽

Cited By ~ 26

Author(s):

Robert H. Bradbury ◽

Neil J. Hales ◽

Alfred A. Rabow ◽

Graeme E. Walker ◽

David G. Acton ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Advanced Prostate Cancer

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Faculty Opinions recommendation of Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.5059957.4994055 ◽

2010 ◽

Author(s):

Michael Weber ◽

Daniel G Gioeli

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Amino Terminus ◽

Recurrent Prostate Cancer ◽

Molecule Inhibitor

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