Abstract LBA016: Androgen Receptor (AR) N-Terminus-Domain-Binding Small Molecule Degraders for the Treatment of AR Splice Variant-Positive Castration-Resistant Prostate Cancer

Mapping Intimacies ◽

10.1158/1535-7163.targ-21-lba016 ◽

2021 ◽

Author(s):

Ramesh Narayanan

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Splice Variant ◽

Castration Resistant Prostate Cancer ◽

Castration Resistant ◽

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Small Molecule Sigma1 Modulators Induce the Degradation of Androgen Receptor and Splice Variants in Castration Resistant Prostate Cancer Cells

10.17918/etd-7165 ◽

2021 ◽

Author(s):

Nan Chen

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Cancer Cells ◽

Small Molecule ◽

Splice Variants ◽

Castration Resistant Prostate Cancer ◽

Prostate Cancer Cells ◽

Castration Resistant

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Structure–Activity Relationships for the Marine Natural Product Sintokamides: Androgen Receptor N-Terminus Antagonists of Interest for Treatment of Metastatic Castration-Resistant Prostate Cancer

Journal of Natural Products ◽

10.1021/acs.jnatprod.0c00921 ◽

2020 ◽

Author(s):

Luping Yan ◽

Carmen A. Banuelos ◽

Nasrin R. Mawji ◽

Brian O. Patrick ◽

Marianne D. Sadar ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Natural Product ◽

Marine Natural Product ◽

Castration Resistant Prostate Cancer ◽

Structure Activity Relationships ◽

Castration Resistant ◽

Structure Activity ◽

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The association between androgen receptor splice variant 7 status and prognosis of metastatic castration‐resistant prostate cancer: A systematic review and meta‑analysis

10.1111/and.13642 ◽

2020 ◽

Vol 52 (7) ◽

Author(s):

Jiatong Zhou ◽

Ranlu Liu

Keyword(s):

Prostate Cancer ◽

Systematic Review ◽

Androgen Receptor ◽

Splice Variant ◽

Meta Analysis ◽

Castration Resistant Prostate Cancer ◽

Castration Resistant ◽

Androgen Receptor Splice Variant

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Clinical Utility of Circulating Tumour Cell Androgen Receptor Splice Variant-7 Status in Metastatic Castration-resistant Prostate Cancer

European Urology ◽

10.1016/j.eururo.2019.04.006 ◽

2019 ◽

Vol 76 (5) ◽

pp. 676-685 ◽

Author(s):

Adam Sharp ◽

Jon C. Welti ◽

Maryou B.K. Lambros ◽

David Dolling ◽

Daniel Nava Rodrigues ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Tumour Cell ◽

Splice Variant ◽

Clinical Utility ◽

Castration Resistant Prostate Cancer ◽

Castration Resistant ◽

Circulating Tumour Cell ◽

Androgen Receptor Splice Variant

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Abstract B107: Characterization of a small molecule selective androgen receptor downregulator: A novel approach for the treatment of castration-resistant prostate cancer.

10.1158/1535-7163.targ-11-b107 ◽

2011 ◽

Author(s):

Sarah A. Loddick ◽

Sandra Brave ◽

Hayley Campbell ◽

Luke Gaughan ◽

Jim Growcott ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Castration Resistant Prostate Cancer ◽

Castration Resistant ◽

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Abstract 2148: Exploitation of androgen receptor splice variant signaling by guanine nucleotide exchange factor Vav3 in castration resistant prostate cancer

10.1158/1538-7445.am2012-2148 ◽

2012 ◽

Author(s):

Stephanie Peacock ◽

Cale Fahrenholtz ◽

Kerry L. Burnstein

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Splice Variant ◽

Guanine Nucleotide ◽

Nucleotide Exchange ◽

Castration Resistant Prostate Cancer ◽

Guanine Nucleotide Exchange ◽

Castration Resistant ◽

Nucleotide Exchange Factor ◽

Androgen Receptor Splice Variant

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Abstract 2910: Androgen receptor splice variant-7 predicts resistance to enzalutamide in patients with castration-resistant prostate cancer

10.1158/1538-7445.am2014-2910 ◽

2014 ◽

Author(s):

Emmanuel S. Antonarakis ◽

Changxue Lu ◽

Hao Wang ◽

Brandon Luber ◽

Mary Nakazawa ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Splice Variant ◽

Castration Resistant Prostate Cancer ◽

Castration Resistant ◽

Androgen Receptor Splice Variant

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Use of nuclear-localized androgen receptor splice variant 7 protein in CTCs after 1st androgen receptor signaling inhibitor (ARSi) as a predictive biomarker for overall survival on a second ARSi or taxane chemotherapy in metastatic castration-resistant prostate cancer (mCRPC)

Annals of Oncology ◽

10.1093/annonc/mdy284.045 ◽

2018 ◽

Vol 29 ◽

pp. viii292-viii293

Author(s):

H.I. Scher ◽

R.P. Graf ◽

M. Hulling ◽

E. Carbone ◽

R. Dittamore

Keyword(s):

Prostate Cancer ◽

Overall Survival ◽

Androgen Receptor ◽

Splice Variant ◽

Predictive Biomarker ◽

Castration Resistant Prostate Cancer ◽

Androgen Receptor Signaling ◽

Castration Resistant ◽

Androgen Receptor Splice Variant ◽

Taxane Chemotherapy

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Reply to Julie Steinestel, Christof Bernemann, Andres J. Schrader, and Jochen K. Lennerz's Letter to the Editor re: Emmanuel S. Antonarakis, Changxue Lu, Brandon Luber, et al. Clinical Significance of Androgen Receptor Splice Variant-7 mRNA Detection in Circulating Tumor Cells of Men with Metastatic Castration-resistant Prostate Cancer Treated with First- and Second-line Abiraterone and Enzalutamide. J Clin Oncol 2017;35:2149–56. AR-V7 Testing: What's in it for the Patient?

European Urology ◽

10.1016/j.eururo.2017.06.032 ◽

2017 ◽

Vol 72 (6) ◽

pp. e170-e171 ◽

Author(s):

Jun Luo ◽

Brandon Luber ◽

Hao Wang ◽

Emmanuel S. Antonarakis

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Tumor Cells ◽

Clinical Significance ◽

Splice Variant ◽

Second Line ◽

Castration Resistant Prostate Cancer ◽

Castration Resistant ◽

Androgen Receptor Splice Variant

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Androgen receptor splice variant, AR-V7, and resistance to enzalutamide and abiraterone in men with metastatic castration-resistant prostate cancer (mCRPC).

Journal of Clinical Oncology ◽

10.1200/jco.2014.32.15_suppl.5001 ◽

2014 ◽

Vol 32 (15_suppl) ◽

pp. 5001-5001 ◽

Author(s):

Emmanuel S. Antonarakis ◽

Changxue Lu ◽

Hao Wang ◽

Brandon Luber ◽

Mary Nakazawa ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Splice Variant ◽

Castration Resistant Prostate Cancer ◽

Castration Resistant ◽

Androgen Receptor Splice Variant

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