In vitro Activity of Rifaximin, Metronidazole and Vancomycin against Clostridium difficile and the Rate of Selection of Spontaneously Resistant Mutants against Representative Anaerobic and Aerobic Bacteria, Including Ammonia-Producing Species

Chemotherapy ◽  
2000 ◽  
Vol 46 (4) ◽  
pp. 253-266 ◽  
Author(s):  
Anna Marchese ◽  
Angelo Salerno ◽  
Adelaide Pesce ◽  
Eugenio A. Debbia ◽  
Gian Carlo Schito
Keyword(s):  
Clostridium Difficile ◽  
Vitro Activity ◽  
Aerobic Bacteria ◽  
In Vitro Activity ◽  
Resistant Mutants ◽  
Selection Of

In vitro activity of cadazolid against Clostridium difficile strains isolated from primary and recurrent infections in Stockholm, Sweden

Anaerobe ◽  
2013 ◽  
Vol 20 ◽  
pp. 32-35 ◽  
Author(s):  
Mamun-Ur Rashid ◽  
Helena Martinez Lozano ◽  
Andrej Weintraub ◽  
Carl Erik Nord
Keyword(s):  
Clostridium Difficile ◽  
Vitro Activity ◽  
Recurrent Infections ◽  
In Vitro Activity

scholarly journals In Vitro Activity of OPT-80 against Clostridium difficile

2004 ◽  
Vol 48 (6) ◽  
pp. 2280-2282 ◽  
Author(s):  
Grit Ackermann ◽  
Birgit Löffler ◽  
Daniela Adler ◽  
Arne C. Rodloff
Keyword(s):  
Clostridium Difficile ◽  
Anaerobic Bacteria ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Obligately Anaerobic ◽  
Nosocomial Diarrhea ◽  
Frequent Relapses

ABSTRACT Clostridium difficile remains the major cause of nosocomial diarrhea. Reports on impaired susceptibility of C. difficile to metronidazole and vancomycin and frequent relapses of patients after therapy necessitate the search for new substances. With this study, the activity of OPT-80, a new macrocycle, against 207 C. difficile strains and against other obligately anaerobic bacteria was tested. OPT-80 showed high in vitro activity against all C. difficile strains tested.

scholarly journals Comparative In Vitro Activities of Ertapenem (MK-0826) against 469 Less Frequently Identified Anaerobes Isolated from Human Infections

2002 ◽  
Vol 46 (4) ◽  
pp. 1136-1140 ◽  
Author(s):  
Ellie J. C. Goldstein ◽  
Diane M. Citron ◽  
C. Vreni Merriam ◽  
Yumi A. Warren ◽  
Kerin L. Tyrrell ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Human Infections

ABSTRACT We studied the in vitro activity of ertapenem against 469 less frequently identified anaerobes from 11 genera and 52 species isolated from human infections. Ertapenem was uniformly active against 460 of 469 (98%) strains at concentrations of ≤4 μg/ml. Only 4 of 14 Clostridium difficile, 1 of 11 Clostridium innocuum, and 4 of 6 Lactobacillus sp. strains required ertapenem concentrations of ≥8 μg/ml for inhibition.

scholarly journals Effect of calcium on in vitro activity of LY146032 against Clostridium difficile.

1987 ◽  
Vol 31 (3) ◽  
pp. 461-462 ◽  
Author(s):  
H Faruki ◽  
A C Niles ◽  
R L Heeren ◽  
P R Murray
Keyword(s):  
Clostridium Difficile ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals Selection of Retapamulin, a Novel Pleuromutilin for Topical Use

2006 ◽  
Vol 50 (11) ◽  
pp. 3882-3885 ◽  
Author(s):  
Stephen Rittenhouse ◽  
Sanjoy Biswas ◽  
John Broskey ◽  
Lynn McCloskey ◽  
Terrance Moore ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pyogenes ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Postantibiotic Effect ◽  
Selection Of

ABSTRACT The in vitro activity of retapamulin was determined and compared to that of topical and community antibiotics. The MIC90s of retapamulin against Staphylococcus aureus and Streptococcus pyogenes were 0.12 μg/ml and 0.016 μg/ml, respectively. Retapamulin has a low propensity to select resistance and produces an in vitro postantibiotic effect.

scholarly journals In Vitro Activity of Tedizolid, Dalbavancin, and Ceftobiprole Against Clostridium difficile

2018 ◽  
Vol 9 ◽  
Author(s):  
Dana Binyamin ◽  
Orna Nitzan ◽  
Maya Azrad ◽  
Zohar Hamo ◽  
Omry Koren ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Vitro Activity ◽  
In Vitro Activity
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