Successful Treatment with Methylprednisolone Pulse Therapy for a Life-Threatening Pulmonary Insufficiency in a Patient with Chronic Granulomatous Disease following Pulmonary Invasive Aspergillosis and Burkholderia cepacia Infection

Respiration ◽  
1999 ◽  
Vol 66 (6) ◽  
pp. 551-554 ◽  
Author(s):  
Motohiko Okano ◽  
Masafumi Yamada ◽  
Makoto Ohtsu ◽  
Nobuaki Kawamura ◽  
Yukio Sakiyama ◽  
...  
Keyword(s):  
Invasive Aspergillosis ◽  
Chronic Granulomatous Disease ◽  
Successful Treatment ◽  
Burkholderia Cepacia ◽  
Pulse Therapy ◽  
Methylprednisolone Pulse Therapy ◽  
Pulmonary Insufficiency ◽  
Granulomatous Disease ◽  
Methylprednisolone Pulse ◽  
Life Threatening

Successful Treatment with Voriconazole of Invasive Aspergillosis in Chronic Granulomatous Disease

1998 ◽  
Vol 157 (5) ◽  
pp. 1694-1696 ◽  
Author(s):  
LOUIS G. van ‘t HEK ◽  
PAUL E. VERWEIJ ◽  
CORRY M. WEEMAES ◽  
ROELOF van DALEN ◽  
JAN-BART YNTEMA ◽  
...  
Keyword(s):  
Invasive Aspergillosis ◽  
Chronic Granulomatous Disease ◽  
Successful Treatment ◽  
Granulomatous Disease

Acute Lupus Peritonitis during Treatment ofLupus Nephritis: Successful Treatment with Methylprednisolone Pulse Therapy

Nephron ◽  
2000 ◽  
Vol 86 (4) ◽  
pp. 511-512 ◽  
Author(s):  
Takashi Uzu ◽  
Yasuhiro Chikamori ◽  
Masaya Yamato ◽  
Hirotsugu Iwatani ◽  
Masahiro Kakihara ◽  
...  
Keyword(s):  
Successful Treatment ◽  
Pulse Therapy ◽  
Methylprednisolone Pulse Therapy ◽  
Methylprednisolone Pulse ◽  
Lupus Peritonitis

scholarly journals Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease

2009 ◽  
Vol 77 (10) ◽  
pp. 4337-4344 ◽  
Author(s):  
Adrian M. Zelazny ◽  
Li Ding ◽  
Houda Z. Elloumi ◽  
Lauren R. Brinster ◽  
Fran Benedetti ◽  
...  
Keyword(s):  
Chronic Granulomatous Disease ◽  
Burkholderia Cepacia ◽  
Cell Entry ◽  
Cellular Interactions ◽  
Granulomatous Disease ◽  
Burkholderia Multivorans ◽  
Healthy Donors ◽  
Cell Association ◽  
Life Threatening ◽  
Shed Light

ABSTRACT Chronic granulomatous disease (CGD) patients are susceptible to life-threatening infections by the Burkholderia cepacia complex. We used leukocytes from CGD and healthy donors and compared cell association, invasion, and cytokine induction by Burkholderia multivorans strains. A CGD isolate, CGD1, showed higher cell association than that of an environmental isolate, Env1, which correlated with cell entry. All B. multivorans strains associated significantly more with cells from CGD patients than with those from healthy donors. Similar findings were observed with another CGD pathogen, Serratia marcescens, but not with Escherichia coli. In a mouse model of CGD, strain CGD1 was virulent while Env1 was avirulent. B. multivorans organisms were found in the spleens of CGD1-infected mice at levels that were 1,000 times higher than those found in Env1-infected mice, which was coincident with higher levels of the proinflammatory cytokine interleukin-1β. Taken together, these results may shed light on the unique susceptibility of CGD patients to specific pathogens.

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