Diabetic Glomerulopathy in Young IDDM Patients

1998 ◽  
Vol 50 (1) ◽  
pp. 17-22 ◽  
Author(s):  
S. Rudberg ◽  
R. Osterby
Keyword(s):  
Diabetic Glomerulopathy

scholarly journals Characteristic Renal Histology of a 81-Year-Old Patient with a 30-Year History of Diabetes Mellitus: A Case Report

2020 ◽  
Vol 9 (4) ◽  
pp. 338-343
Author(s):  
Natsuki Shima ◽  
Naoki Sawa ◽  
Masayuki Yamanouchi ◽  
Hiroki Mizuno ◽  
Masahiro Kawada ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Immunofluorescence Microscopy ◽  
Antihypertensive Agents ◽  
Diabetic Glomerulopathy ◽  
Normal Range ◽  
Salt Diet ◽  
Protein Excretion ◽  
Renal Histology ◽  
History Of ◽  
Arteriolar Hyalinosis

Abstract A renal histology of an 81-year-old man with a 30-year history of diabetes mellitus (DM), as well as diabetic retinopathy and neuropathy, was examined. The patient’s blood pressure was controlled within the normal range (less than 140/75 mmHg) using antihypertensive agents including angiotensin receptor blocker. Edematous management was achieved by a strict salt diet (less than 6 g/per day). However, this patient’s glycemic control was poor with HbA1c 8–10%. Serum creatinine was 0.87 mg/dL and estimated globular filtration rate (eGFR) was 64 ml/min/1.73m2. Urinary protein excretion was 1.5 g/day. This patient’s renal biopsy showed linear staining for IgG along the GBM by immunofluorescence microscopy, but light microscopy showed almost intact glomeruli, and the GBM was not thickened as revealed by electron microscopy with a width of 288–368 nm (< 430 nm). While arteriolar hyalinosis was severe, and polar vasculosis was observed around the glomerular vascular pole. This case indicates that long-standing hyperglycemia may induce polar vasculosis by the mechanism of angiogenesis, but diabetic glomerulopathy can become minor change, only when hypertension and edematous management could be controlled strictly.

Steroid-Responsive Relapsing Nephrotic Syndrome Associated with Early Diabetic Glomerulopathy in a Child

Nephron ◽  
1987 ◽  
Vol 46 (1) ◽  
pp. 78-82 ◽  
Author(s):  
R. Peces ◽  
J.R. Riera ◽  
C. López Larrea ◽  
J. Alvarez
Keyword(s):  
Nephrotic Syndrome ◽  
Diabetic Glomerulopathy
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