Is Heart Rate Reduction Beneficial to Patients with Chronic Congestive Heart Failure?

Heart Drug ◽  
2002 ◽  
Vol 2 (3) ◽  
pp. 135-141 ◽  
Author(s):  
Otto Mølby Henriksen ◽  
Niels Gadsbøll
Keyword(s):  
Heart Failure ◽  
Heart Rate ◽  
Congestive Heart Failure ◽  
Chronic Congestive Heart Failure ◽  
Heart Rate Reduction ◽  
Rate Reduction

scholarly journals Effects on Outcomes of Heart Rate Reduction by Ivabradine in Patients With Congestive Heart Failure: Is There an Influence of Beta-Blocker Dose?

2012 ◽  
Vol 59 (22) ◽  
pp. 1938-1945 ◽  
Author(s):  
Karl Swedberg ◽  
Michel Komajda ◽  
Michael Böhm ◽  
Jeffrey Borer ◽  
Michele Robertson ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Rate ◽  
Congestive Heart Failure ◽  
Beta Blocker ◽  
Heart Rate Reduction ◽  
Rate Reduction

scholarly journals Heart rate reduction and exercise performance in recent onset heart failure with reduced ejection fraction: arguments for beta-blocker hypo-response

2015 ◽  
Vol 70 (5) ◽  
pp. 565-572
Author(s):  
Frederik H. Verbrugge ◽  
Jeroen Vrijsen ◽  
Jan Vercammen ◽  
Lars Grieten ◽  
Matthias Dupont ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Rate ◽  
Ejection Fraction ◽  
Beta Blocker ◽  
Exercise Performance ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Reduced Ejection Fraction ◽  
Recent Onset

Baro- and ventricular reflexes in conscious dogs subjected to chronic tachycardia

1992 ◽  
Vol 263 (4) ◽  
pp. H1084-H1089 ◽  
Author(s):  
J. S. Chen ◽  
W. Wang ◽  
K. G. Cornish ◽  
I. H. Zucker
Keyword(s):  
Heart Failure ◽  
Heart Rate ◽  
Congestive Heart Failure ◽  
Clinical Signs ◽  
Chronic Congestive Heart Failure ◽  
Ventricular Pacing ◽  
Arterial Baroreflex ◽  
Failure State ◽  
Before And After ◽  
Blood Pressure Responses

It has been well documented that the arterial baroreflex is depressed in chronic congestive heart failure. Furthermore, cardiopulmonary reflexes have also been shown to be depressed in heart failure. Because cardiac reflexes can be mediated by both mechanical and chemical stimuli, we undertook the current study to determine whether chemically activated cardiac reflexes (Bezold-Jarisch) are abnormally depressed in dogs with chronic heart failure at a point in time when arterial baroreflexes were clearly depressed. We studied heart rate and arterial pressure responses in 13 conscious instrumented dogs before and after chronic ventricular pacing at 250 beats/min for 4-5 wk. At the time the study was done each dog showed both hemodynamic and clinical signs of congestive heart failure. The arterial baroreflex was evaluated by analyzing the heart rate response to acute injections of phenylephrine and nitroglycerin. The Bezold-Jarisch reflex was assessed in nine dogs by determining the heart rate and blood pressure responses to intracoronary injections of various doses of veratridine. Arterial baroreflex responses were uniformly depressed following ventricular pacing. The phenylephrine slope was reduced by 55.8 +/- 6.9% (P < 0.001), and the nitroglycerin slope was reduced by 67.9 +/- 5.0% (P < 0.0001) in the heart failure state. Significant bradycardia and hypotension were seen at each dose of veratridine given (0.01, 0.1, and 0.4 microgram/kg). When compared with the prepaced control state, the magnitude of the hypotension was no different in the heart failure state in response to any dose of veratridine.(ABSTRACT TRUNCATED AT 250 WORDS)

Effects of chronic congestive heart failure on 24-hour blood pressure and heart rate patterns: A hemodynamic approach

1992 ◽  
Vol 123 (4) ◽  
pp. 998-1004 ◽  
Author(s):  
Philippe van de Borne ◽  
Michel Abramowicz ◽  
Serge Degre ◽  
Jean-Paul Degaute
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Heart Rate ◽  
Congestive Heart Failure ◽  
Chronic Congestive Heart Failure

The effect of heart rate reduction with ivabradine on renal function in patients with chronic heart failure: an analysis from SHIFT

2014 ◽  
Vol 16 (4) ◽  
pp. 426-434 ◽  
Author(s):  
Adriaan A. Voors ◽  
Dirk J. van Veldhuisen ◽  
Michele Robertson ◽  
Ian Ford ◽  
Jeffrey S. Borer ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Rate ◽  
Renal Function ◽  
Chronic Heart Failure ◽  
Heart Rate Reduction ◽  
Rate Reduction
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