Immunological Variables Mediate Cognitive Dysfunction in Gulf War Veterans but Not Civilians with Chronic Fatigue Syndrome

2002 ◽  
Vol 10 (2) ◽  
pp. 93-100 ◽  
Author(s):  
Michael Brimacombe ◽  
QuanWu Zhang ◽  
Gudrun Lange ◽  
Benjamin H. Natelson
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Cognitive Dysfunction ◽  
Chronic Fatigue ◽  
Gulf War ◽  
War Veterans ◽  
Gulf War Veterans ◽  
Fatigue Syndrome

Perceived Exertion in Fatiguing Illness: Gulf War Veterans with Chronic Fatigue Syndrome

2003 ◽  
Vol 35 (4) ◽  
pp. 569-574 ◽  
Author(s):  
DANE B. COOK ◽  
PAUL R. NAGELKIRK ◽  
ARNOLD PECKERMAN ◽  
ASHOK POLURI ◽  
JOHN J. LAMANCA ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Perceived Exertion ◽  
Chronic Fatigue ◽  
Gulf War ◽  
War Veterans ◽  
Gulf War Veterans ◽  
Fatigue Syndrome

Chronic Fatigue Syndrome in Male Gulf War Veterans and Civilians

2008 ◽  
Vol 13 (4) ◽  
pp. 529-536 ◽  
Author(s):  
Donald S. Ciccone ◽  
Lois Weissman ◽  
Benjamin H. Natelson
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Gulf War ◽  
War Veterans ◽  
Gulf War Veterans ◽  
Fatigue Syndrome

scholarly journals Systematic review of multi-symptom conditions in Gulf War veterans

2006 ◽  
Vol 36 (6) ◽  
pp. 735-747 ◽  
Author(s):  
HOLLIE V. THOMAS ◽  
NICOLA J. STIMPSON ◽  
ALISON L. WEIGHTMAN ◽  
FRANK DUNSTAN ◽  
GLYN LEWIS
Keyword(s):  
Systematic Review ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Multiple Chemical Sensitivity ◽  
Gulf War ◽  
Chemical Sensitivity ◽  
War Veterans ◽  
Gulf War Veterans ◽  
Fatigue Syndrome ◽  
Multiple Chemical

Background. Gulf War veterans have a number of health complaints. We therefore decided to carry out a systematic review to identify and summarize the findings from studies that have assessed multi-symptom conditions in Gulf War veterans and in an unexposed comparison group.Method. Studies published between January 1990 and May 2004 were identified by searching a large number of electronic databases. Reference lists and websites were also searched and key researchers were contacted. Studies were included if they compared the prevalence of chronic fatigue syndrome, multiple chemical sensitivity, CDC-defined chronic multi-symptom illness, fibromyalgia, or symptoms of either fatigue or numbness and tingling in Gulf War veterans and non-Gulf veterans. A total of 2401 abstracts were independently reviewed by two authors.Results. Twenty-three publications fulfilled the inclusion criteria. Gulf deployment was most strongly associated with chronic fatigue syndrome (OR 3·8, 95% CI 2·2–6·7). Gulf War veterans were also approximately three and a half times more likely than non-Gulf veterans to report multiple chemical sensitivity or chronic multi-symptom illness as defined by CDC. The methodological quality of the studies varied but the later and larger studies were of a high methodological standard with robust sampling strategies, adequate response rates and good adjustment for confounders.Conclusions. The results support the hypothesis that deployment to the Gulf War is associated with greater reporting of multi-symptom conditions.

scholarly journals Aerobic Capacity of Gulf War Veterans with Chronic Fatigue Syndrome

2003 ◽  
Vol 168 (9) ◽  
pp. 750-755 ◽  
Author(s):  
Nagelkirk Paul R. ◽  
Dane B. Cook ◽  
Arnold Peckerman ◽  
William Kesil ◽  
Tracy Sakowski ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Aerobic Capacity ◽  
Chronic Fatigue ◽  
Gulf War ◽  
War Veterans ◽  
Gulf War Veterans ◽  
Fatigue Syndrome

Quantitative sensory testing in gulf war veterans with chronic fatigue syndrome

1999 ◽  
Vol 1 (4) ◽  
pp. 235-240 ◽  
Author(s):  
Arnold Peckerman ◽  
Benjamin H. Natelson ◽  
Howard Kipen ◽  
Sharon L. Smith ◽  
Kristina Dahl ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Quantitative Sensory Testing ◽  
Chronic Fatigue ◽  
Gulf War ◽  
Sensory Testing ◽  
War Veterans ◽  
Gulf War Veterans ◽  
Fatigue Syndrome

scholarly journals Characterising the gut microbiome in veterans with Gulf War Illness: a protocol for a longitudinal, prospective cohort study

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e031114 ◽  
Author(s):  
Julie A Keating ◽  
Catherine Shaughnessy ◽  
Kelsey Baubie ◽  
Ashley E Kates ◽  
Nathan Putman-Buehler ◽  
...  
Keyword(s):  
Cohort Study ◽  
Gut Microbiome ◽  
Chronic Fatigue ◽  
Gulf War ◽  
Case Definition ◽  
Gulf War Illness ◽  
War Veterans ◽  
Gulf War Veterans ◽  
Fatigue Syndrome ◽  
Institutional Review

IntroductionApproximately 25%–35% of the 1991 Gulf War Veteran population report symptoms consistent with Gulf War Illness (GWI), a chronic, multi-symptom illness characterised by fatigue, pain, irritable bowel syndrome and problems with cognitive function. GWI is a disabling problem for Gulf War Veterans, and there remains a critical need to identify innovative, novel therapies.Gut microbiota perturbation plays a key role in the symptomatology of other chronic multi-symptom illnesses, including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Given similarities between ME/CFS and GWI and the presence of gastrointestinal disorders in GWI patients, Veterans with GWI may also have gut abnormalities like those seen with ME/CFS. In this longitudinal cohort study, we are comparing the diversity (structure) and the metagenomes (function) of the gut microbiome between Gulf War Veterans with and without GWI. If we find differences in Veterans with GWI, the microbiome could be a target for therapeutic intervention to alleviate GWI symptoms.Methods and analysisParticipants answer questions about diet, exercise and lifestyle factors. Participants also complete a questionnaire (based on the Kansas case definition of GWI) regarding their medical history and symptoms; we use this questionnaire to group participants into GWI versus healthy control cohorts. We plan to enrol 52 deployed Gulf War Veterans: 26 with GWI and 26 healthy controls. Participants provide stool and saliva samples weekly for an 8-week period for microbiome analyses. Participants also provide blood samples at the beginning and end of this period, which we will use to compare measures of inflammation markers between the groups.Ethics and disseminationThe protocol was approved by the University of Wisconsin-Madison Health Sciences Institutional Review Board and the William S. Middleton Memorial Veterans Hospital Research and Development Committee. Results of this study will be submitted for publication in a peer-reviewed journal.

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