scholarly journals Early Changes in Thyroid-Stimulating Antibody Activity following Radioiodine Therapy

2003 ◽  
Vol 12 (4) ◽  
pp. 266-268 ◽  
Author(s):  
Akheel A. Syed ◽  
Carol Evans ◽  
Marian Ludgate ◽  
John H. Lazarus
Keyword(s):  
Radioiodine Therapy ◽  
Antibody Activity ◽  
Thyroid Stimulating Antibody

Appearance of thyroid stimulating antibody and Graves' disease after radioiodine therapy for toxic nodular goitre

1994 ◽  
Vol 40 (6) ◽  
pp. 803-806 ◽  
Author(s):  
Luca Chiovato ◽  
Ferruccio Santini ◽  
Paolo Vitti ◽  
Giovanna Bendinelli ◽  
Aldo Pinchera
Keyword(s):  
Radioiodine Therapy ◽  
Graves Disease ◽  
Nodular Goitre ◽  
Thyroid Stimulating Antibody ◽  
Toxic Nodular Goitre

scholarly journals Study of processing for measurement of thyroid stimulating antibody activity(TSAb%)

1997 ◽  
Vol 53 (7) ◽  
pp. 928
Author(s):  
Takeshi Uemura ◽  
Hiroshi Kameyama ◽  
Hidezou Noguchi
Keyword(s):  
Antibody Activity ◽  
Thyroid Stimulating Antibody

scholarly journals Immunization with thyroglobulin induces Graves'-like disease in mice

2009 ◽  
Vol 202 (2) ◽  
pp. 217-222 ◽  
Author(s):  
Toyoshi Endo ◽  
Tetsuro Kobayashi
Keyword(s):  
High Titer ◽  
High Serum ◽  
Graves Disease ◽  
Antibody Activity ◽  
Iodide Uptake ◽  
Serum Free ◽  
Thyroid Stimulating Antibody ◽  
Thyroid Glands ◽  
Diffuse Goiter ◽  
Uptake Activity

We immunized AKR/N mice with bovine thyroglobulin (Tg) once every 2 weeks and monitored their time-dependent changes in 125I uptake activity in the thyroid glands. After 3 months, anti-Tg antibody was positive in all sera from the immunized mice. Serum free tri-iodothyronine (T3) and free thyroxine (T4) levels in the immunized mice (n=6) were significantly higher than those in the saline injected (control) mice (n=6). Neck counts as well as scintigraphy of the thyroid glands revealed that iodide uptake activity of the immunized mice was not suppressed, but was instead higher than that of the control mice. Two of the six immunized mice showed extremely high iodide uptake activity. The thyroid glands of these two mice were diffusely enlarged and the height of the epithelial cells was also increased. In addition, two mice with high iodide uptake activity produced a high titer of thyroid-stimulating antibody. Additional experiments showed that 4 out of 11 AKR/N mice and 3 out of 10 C57BL6 mice immunized with Tg had high serum free T3/free T4 levels, high 125I uptake activity of the thyroid, and positive thyroid-stimulating antibody activity. Diffuse goiter, thyrotoxicosis, high iodide uptake activity, and positive thyroid-stimulating antibody are the characteristics of Graves' disease. Thus, these mice exhibit the symptoms of Graves' disease. These results suggest that immunization with Tg induces Graves'-like disease in mice and that our methods will provide a new animal model of Graves' disease.

scholarly journals Thyroid-stimulating antibody activity between different immunoglobulin G subclasses.

1990 ◽  
Vol 86 (3) ◽  
pp. 723-727 ◽  
Author(s):  
A P Weetman ◽  
M E Yateman ◽  
P A Ealey ◽  
C M Black ◽  
C B Reimer ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Antibody Activity ◽  
Thyroid Stimulating Antibody ◽  
Immunoglobulin G Subclasses

scholarly journals Susceptibility Rather than Resistance to Hyperthyroidism Is Dominant in a Thyrotropin Receptor Adenovirus-Induced Animal Model of Graves’ Disease as Revealed by BALB/c-C57BL/6 Hybrid Mice

Endocrinology ◽  
2004 ◽  
Vol 145 (11) ◽  
pp. 4927-4933 ◽  
Author(s):  
Chun-Rong Chen ◽  
H. Aliesky ◽  
P. N. Pichurin ◽  
Y. Nagayama ◽  
S. M. McLachlan ◽  
...  
Keyword(s):  
Dominant Gene ◽  
F1 Hybrids ◽  
Graves Disease ◽  
Antibody Activity ◽  
Igg Subclass ◽  
Potential Candidate ◽  
T Helper ◽  
Blocking Antibody ◽  
Thyroid Stimulating Antibody ◽  
A Subunit

Abstract We investigated why TSH receptor (TSHR) adenovirus immunization induces hyperthyroidism more commonly in BALB/c than in C57BL/6 mice. Recent modifications of the adenovirus model suggested that using adenovirus expressing the TSHR A subunit (A-subunit-Ad), rather than the full-length TSHR, and injecting fewer viral particles would increase the frequency of hyperthyroidism in C57BL/6 mice. This hypothesis was not fulfilled; 65% of BALB/c but only 5% of C57BL/6 mice developed hyperthyroidism. TSH binding inhibitory antibody titers were similar in each strain. Functional TSHR antibody measurements provided a better indication for this strain difference. Whereas thyroid-stimulating antibody activity was higher in C57BL/6 than BALB/c mice, TSH blocking antibody activity was more potent in hyperthyroid-resistant C57BL/6 mice. F1 hybrids (BALB/c × C57BL/6) responded to A-subunit-Ad immunization with hyperthyroidism and TSHR antibody profiles similar to those of the hyperthyroid-susceptible parental BALB/c strain. In contrast, ELISA of TSHR antibodies revealed that the IgG subclass distribution in the F1 mice resembled the disease-resistant C57BL/6 parental strain. Because the IgG subclass distribution is dependent on the T helper 1/T helper 2 cytokine balance, this paradigm can likely be excluded as an explanation for susceptibility to hyperthyroidism. In summary, our data for BALB/c, C57BL/6, and F1 strains suggest that BALB/c mice carry a dominant gene(s) for susceptibility to induction of a thyroid-stimulating antibody/TSH blocking antibody balance that results in hyperthyroidism. Study of this genetic influence will provide useful information on potential candidate genes in human Graves’ disease.

A synthetic oligopeptide derived from human thyrotropin receptor sequence binds to Graves' immunoglobulin and inhibits thyroid stimulating antibody activity but lacks interactions with TSH

1991 ◽  
Vol 178 (1) ◽  
pp. 165-172 ◽  
Author(s):  
Toru Mori ◽  
Hideo Sugawa ◽  
Thavatchai Piraphatdist ◽  
Daisuke Inoue ◽  
Tetsuya Enomoto ◽  
...  
Keyword(s):  
Antibody Activity ◽  
Thyrotropin Receptor ◽  
Thyroid Stimulating Antibody

The FUSION iENA Study: Comparison of I-124-PET/US Fusion Imaging with Conventional Diagnostics for the Functional Assessment of Thyroid Nodules by Multiple Observers

2019 ◽  
Vol 58 (06) ◽  
pp. 434-442 ◽  
Author(s):  
Thomas Winkens ◽  
Philipp Seifert ◽  
Christian Hollenbach ◽  
Christian Kühnel ◽  
Falk Gühne ◽  
...  
Keyword(s):  
Functional Assessment ◽  
Thyroid Nodules ◽  
Radioiodine Therapy ◽  
Fusion Imaging ◽  
Needle Aspiration ◽  
Patient Case ◽  
Positron Emission ◽  
Thyroid Medication ◽  
Case Files

Abstract Aim To investigate the value of I-124 positron emission tomography (PET) / ultrasound (US) fusion imaging in comparison to conventional diagnostics (CD) of Thyroid nodules (TN) by multiple observers. Methods Digital patient case files (PCF) of patients that received CD and I-124-PET/US in clinical routine were prepared containing cine-loops of the examinations. All physicians with nuclear medicine specialty from Germany, Austria, and Switzerland were invited to participate. 106 acquired observers completed 7.2 ± 1.8 (median: 8, range: 4–14) randomly assigned PCF (CD only or CD+PET/US). They assessed the TN function, stated their confidence in functional assessment, and suggested a treatment course for each TN. Results 68 PCF of 34 patients comprising 66 TN ≥ 1 cm (= 1.94 TN/patient) were created. A total of 748 (11.2/TN), and 751 ratings (11.4/TN) were recorded for CD only, and CD+PET/US, respectively. The functional assessment revealed more hyper- or hypofunctioning (524 vs. 320, p < 0.0001) and less indifferent or not rateable (209 vs. 428, p < 0.0001) TN in CD+PET/US vs. CD only. The observers’ confidence in functional assessment was superior in CD+PET/US (p < 0.0001). Furthermore, the ratings were carried out more homogeneous in CD+PET/US (p < 0.0001). Fewer suggestion of follow up (p < 0.0001), and more (p < 0.0001) suggestion of invasive treatments (fine-needle aspiration & surgery) was observed in CD+PET/US. Radioiodine therapy was more often (p = 0.0036), and thyroid medication less often (p = 0.0167) advised in CD+PET/US. Conclusion Functional assessment of equivocal TN shows frequent failures in CD, underestimating the incidence of hyper- and hypofunctioning lesions. Confidence in functional assessment significantly increases with additional PET/US. This influences the proposed treatment course.

The Effect of Carbimazole Following Radioiodine Therapy on Radiation Dose to the Thyroid

1981 ◽  
Vol 20 (02) ◽  
pp. 72-75 ◽  
Author(s):  
R. Kocak ◽  
R.G. Herbert ◽  
C.R. Squire ◽  
T.M.D. Gimlette
Keyword(s):  
Thyroid Gland ◽  
Radiation Dose ◽  
Half Life ◽  
Radioiodine Therapy

Radioiodine in the thyroid gland after a therapy dose of 131I was measured serially in 7 patients without Carbimazole, and in 11 patients starting Carbimazole 60 mg daily fourteen days after the therapy dose. Effective half-life for radioiodine in the gland initially 5.53±1.08 days fell to 4.26±1.12 days (p < 0.01) during Carbimazole, and returned to 5.83±1.21 days (NS) after stopping the drug. The radiation dose to the thyroid from a given therapy dose of 131I followed by Carbimazole was calculated to be 97% of that without Carbimazole when the drug was started after 14 days, and 90% and 75% when the drug was started after 7 days and 1 day respectively.

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