Role of Latent Genital Tuberculosis in Repeated IVF Failure in the Indian Clinical Setting

AbstractMany individuals develop a temporary state of cognitive and emotional impairment after being diagnosed with catastrophic illness. Thus, when crucial decisions about medical treatment are required, they are unable to assimilate information; or worse, the legal need to be informed can rival a psychological desire to not be informed. The Canadian informed consent doctrine is unresponsive to crisis and clinically impracticable, and so paradoxically compromises the integrity and autonomy it was designed to protect. Many aspects of the physician-patient relationship and clinical setting also undermine the philosophical values enshrined in this doctrine. This further jeopardizes the individual's integrity. The Article explores proposals for change such as delaying the informing and consenting, improving the concept of consent, and improving the role of the physician.

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Cetirizine versus diphenhydramine in the prevention of chemotherapy-related hypersensitivity reactions

Journal of Oncology Pharmacy Practice ◽

10.1177/1078155218811505 ◽

2018 ◽

Vol 25 (6) ◽

pp. 1396-1401 ◽

Cited By ~ 2

Author(s):

Charis G Durham ◽

Deepthi Thotakura ◽

Lauren Sager ◽

Jennifer Foster ◽

Jon D Herrington

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Retrospective Study ◽

Prospective Studies ◽

Clinical Setting ◽

Hypersensitivity Reactions ◽

Efficacy And Safety ◽

Infusion Reactions

Objective This study evaluated the role of cetirizine compared to diphenhydramine as premedications for patients receiving paclitaxel, cetuximab, and rituximab infusions. Historically, diphenhydramine has been linked with more sedation in comparison to cetirizine; however, it is unknown if cetirizine can replace diphenhydramine in the prevention of hypersensitivity reactions in patients receiving chemotherapy. Methods This is a retrospective study designed to assess infusion reactions occurring in patients receiving diphenhydramine or cetirizine premedication for rituximab, paclitaxel, or cetuximab therapies. Infusion reactions were defined as various symptoms such as flushing, itching, alterations in heart rate and blood pressure, and dyspnea plus the clinical setting of a concurrent or very recent infusion. Results A total of 207 patients were evaluated in this study with 83 patients receiving cetirizine and 124 diphenhydramine patients. Overall, the percentage of patients with at least one chemotherapy-related infusion event in the cetirizine group was 19.3% (95% CI 11.4–29.4) compared to diphenhydramine group 24.2% (95% CI 17.0–32.7), P = 0.40. Of the patients who received cetirizine and then experienced an event in the first cycle, 41.7% (95% CI 13.7–74.3) of the events were due to paclitaxel, 50.0% (95% CI 19.4–80.6) were due to rituximab, and 8.3% (95% CI 0.1–43.6) were due to cetuximab. Of the patients who received diphenhydramine and then experienced an event in the first cycle, 26.1% (95% CI 5.7–51.4) were due to paclitaxel, 73.9% (95% CI 48.6–94.3) were due to rituximab and none due to cetuximab. Conclusion Cetirizine appears to be a viable substitute for diphenhydramine for the prevention of infusions reactions with cetuximab, paclitaxel, and rituximab infusions in adults. Prospective studies are needed to determine the efficacy and safety of cetirizine compared with diphenhydramine in the prevention of chemotherapy-related infusion reactions.

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Granulocyte Transfusions

PEDIATRICS ◽

10.1542/peds.81.6.915a ◽

1988 ◽

Vol 81 (6) ◽

pp. 915-915

Author(s):

MITCHELL S. CAIRO

Keyword(s):

Supportive Care ◽

Preterm Infants ◽

Clinical Setting ◽

Neonatal Sepsis ◽

Statistical Significance ◽

Buffy Coat ◽

Granulocyte Transfusion

In Reply.— The comments raised by Baley et al are well taken and bring up one of the most important variables in the role of granulocyte transfusion in neonatal sepsis. Most of the studies to date have involved small numbers of patients in single institutions. This has prevented us from accumulating a large enough population of patients to adequately assess the role of either buffy coat transfusions or leukapheresed transfusions in this clinical setting. My comments in the commentary suggested that, with only eight patients in a group of preterm infants with presumed sepsis and only five patients with presumed sepsis with birth weights greater than 1,500 g, the numbers are essentially too small to determine any statistical significance between the role of buffy coat transfusions or supportive care.

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The role of the assistant practitioner in the clinical setting: a focus group study. Part 1

British Journal of Healthcare Assistants ◽

10.12968/bjha.2019.13.2.94 ◽

2019 ◽

Vol 13 (2) ◽

pp. 94-99 ◽

Cited By ~ 1

Author(s):

Catherine Henshall ◽

Andrea Doherty ◽

Helen Green ◽

Liz Westcott ◽

Helen Aveyard

Keyword(s):

Focus Group ◽

Clinical Setting ◽

Focus Group Study ◽

Assistant Practitioner

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Etiopathogenesis, Challenges and Remedies Associated With Female Genital Tuberculosis: Potential Role of Nuclear Receptors

Frontiers in Immunology ◽

10.3389/fimmu.2020.02161 ◽

2020 ◽

Vol 11 ◽

Author(s):

Shalini Gupta ◽

Pawan Gupta

Keyword(s):

Nuclear Receptors ◽

Potential Role ◽

Genital Tuberculosis ◽

Female Genital Tuberculosis ◽

Female Genital

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Role of diuretics, hormonal derangements, and clinical setting of hyponatremia in medical patients

Klinische Wochenschrift ◽

10.1007/bf01726923 ◽

1988 ◽

Vol 66 (15) ◽

pp. 662-669 ◽

Cited By ~ 29

Author(s):

P. Gross ◽

M. Ketteler ◽

C. Hausmann ◽

C. Reinhard ◽

A. Schömig ◽

...

Keyword(s):

Clinical Setting ◽

Medical Patients

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Ulipristal acetate (UPA) for fibroids–IVF outcomes following treatment with UPA after IVF failure: series of 2 case reports

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20172959 ◽

2017 ◽

Vol 6 (7) ◽

pp. 3177 ◽

Cited By ~ 1

Author(s):

Ashish R Kale

Keyword(s):

Case Reports ◽

Uterine Fibroids ◽

Case Series ◽

Standard Of Care ◽

Infertile Woman ◽

Ulipristal Acetate ◽

Uterine Tumors ◽

Size Number ◽

Ivf Failure

Uterine fibroids (also known as leiomyomas or myomas) are the most common form of benign uterine tumors. Fibroids are present in 5-10% of infertile patients, and may be the sole cause of infertility in 1-2.4%. The removal of fibroids by hysteroscopy and laparoscopy has now become the standard of care depending upon the size, number and location of fibroids in an infertile woman. Off lately, there is growing evidence of the crucial role of progesterone pathways in the pathophysiology of uterine fibroids due to the use of selective progesterone receptor modulators (SPRMs) such as ulipristal acetate (UPA). Here, we report a case series of 2 women, with fibroids, who were put on UPA prior to IVF. These women had at least one previous IVF failure. The pre and post UPA fibroid characteristics were compared to see the effect of the drug. IVF was done post 3 month UPA therapy. Both the women showed a drastic reduction in the fibroid size, increased distance from endometrial cavity, and successful post UPA IVF cycles. Safety of the drug has been proven in few recent trials, but the role of UPA in infertile women with fibroids, who have had previous IVF failure, has opened new horizons in this field.

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