Reflex-Epilepsy Induced by Immersion in Hot Water

1988 ◽  
Vol 28 (1) ◽  
pp. 6-10 ◽  
Author(s):  
R.A.C. Roos ◽  
J.G. van Dijk
Keyword(s):  
2020 ◽  
Vol 51 (05) ◽  
pp. 336-340 ◽  
Author(s):  
Fatma Hanci ◽  
Sevim Türay ◽  
Paşa Balci ◽  
Nimet Kabakuş

AbstractHot water epilepsy (HWE) is a subtype of reflex epilepsy in which seizures are triggered by the head being immersed in hot water. Hot water or bathing epilepsy is the type of reflex epilepsy most frequently encountered in our clinic. We describe our patients with HWE and also discuss the clinical features, therapeutic approaches, and prognosis. Eleven patients (10 boys, 1 girl), aged 12 months to 13 years, admitted to the pediatric neurology clinic between January 2018 and August 2019, and diagnosed with HWE or bathing epilepsy based on International League Against Epilepsy (ILAE)-2017, were followed up prospectively for ∼18 months. Patients' clinical and electroencephalography (EEG) findings and treatment details were noted. All 11 patients' seizures were triggered by hot water. Age at first seizure was between 2 months and 12 years. Seizure types were generalized motor seizures, absence, and atonic. EEG was normal in two patients, but nine patients had epileptiform discharges. Magnetic resonance imaging of the brain was performed and reported as normal (except in one case). Histories of prematurity were present in two patients, unprovoked seizures in one, and low birth weight and depressed birth in the other. Patients with HWE have normal neuromuscular development and neurological examination results, together with prophylaxis or seizure control with a single antiepileptic drug, suggesting that it is a self-limited reflex epilepsy.


2010 ◽  
Vol 2010 ◽  
pp. 1-2 ◽  
Author(s):  
Aysel Milanlıoğlu ◽  
Temel Tombul ◽  
Refah Sayın

Hot water epilepsy is a unique form of reflex epilepsy precipitated by the stimulus of bathing with hot water poured over the head. It is mostly seen in infants and children, with a predominance in males. Unlikely, we present a 32-year-old pregnancy woman with the incipient of reflex seizures triggered by pouring hot water over the head while having a bath during the gestation period and treated successfully with carbamazepine 400 mg/day therapy. Hot water epilepsy is known as a benign and self-limited reflex epilepsy, by firstly avoiding hot water or long showers and secondly using intermittent benzodiazepines or conventional antiepileptic drugs, may be sufficient to be seizure-free.


2015 ◽  
Vol 19 ◽  
pp. S86
Author(s):  
A. Mosquera Gorostidi ◽  
G. Azcona Ganuza ◽  
A. Justo Ranera ◽  
I.G. de Gurtubay ◽  
S. Aguilera Albesa ◽  
...  
Keyword(s):  

2015 ◽  
Vol 06 (04) ◽  
pp. 607-609 ◽  
Author(s):  
Rajath Pejaver ◽  
V. Srinivasa ◽  
S. P. Basavanthappa ◽  
C. L. Srinivasa Murthy

ABSTRACTHot water epilepsy (HWE) is a type of reflex epilepsy which occurs when hot water is poured over the head. Most cases have been reported from Southern India. Genetic, cultural, and geographical factors can be responsible for HWE. HWE can be treated by clobazam 1–2 h prior to take a bath rather than continuous anti-epileptic therapy. Medication prior to bathing may be useful in treating older children, eliminating the need to be accompanied by an adult during bathing. It can also be treated by reducing the temperature of the water used for bathing. Here, we report three cases of HWE in varying age groups.


Epilepsia ◽  
1988 ◽  
Vol 29 (1) ◽  
pp. 52-56 ◽  
Author(s):  
P. Satishchandra ◽  
A. Shivaramakrishana ◽  
V. G. Kaliaperumal ◽  
Bruce S. Schoenberg

2009 ◽  
Vol 126 (5) ◽  
pp. 677-683 ◽  
Author(s):  
Rinki Ratnapriya ◽  
Parthasarthy Satishchandra ◽  
S. Dilip ◽  
Girish Gadre ◽  
Anuranjan Anand

2009 ◽  
Vol 125 (5-6) ◽  
pp. 541-549 ◽  
Author(s):  
Rinki Ratnapriya ◽  
Parthasarthy Satishchandra ◽  
S. Dilip Kumar ◽  
Girish Gadre ◽  
Ramesh Reddy ◽  
...  

2016 ◽  
Vol 18 (2) ◽  
pp. 86-86
Author(s):  
Özgür TATLI ◽  
Selim YURTSEVER ◽  
Mücahit GÜNAYDIN ◽  
Faruk ÖZŞAHİN ◽  
Gürkan ALTUNTAŞ ◽  
...  
Keyword(s):  

2010 ◽  
Vol 01 (02) ◽  
pp. 099-101
Author(s):  
Riazahmed Syed

ABSTRACTHot water epilepsy is a form of reflex epilepsy in childhood. We report two children from Saudi Arabia, who presented with seizures following pouring hot water on their head, while bathing. They were not treated by anti-epileptic medication. By decreasing the temperature of the water used for bathing, the seizures were avoided to a large extent in them. This form of epilepsy is reported to be seldom present in various countries but there are no records of its presence in Saudi Arabia.


2019 ◽  
Author(s):  
Shalini Roy Choudhury ◽  
Parthasarathy Satishchandra ◽  
Sanjib Sinha ◽  
Anuranjan Anand

AbstractHot water epilepsy (HWE) is a sensory reflex epilepsy in which seizures are precipitated by a stimulus such as contact with hot water. While there is a genetic basis to its etiology, identity of the genes underlying this relatively uncommon disorder has remained unknown. Here, we present the results of our studies aimed at identifying a causative gene in a south Indian four-generation family with several affected members. We conducted whole-exome sequencing and examined a known locus that maps to 4q24-q28 (HWE2, MIM: 613340) that we had previously identified. We identified a sequence variant, c.1805C>T (p.Thr602Ile) in ZGRF1, located within the HWE2 locus, co-segregating with the disorder. The transcript structure of ZGRF1 was examined in 288 HWE patients, and five additional missense variants, Arg326Gln, Glu660Gly, Arg1862*, Phe1940Leu and Asp1984Gly, present exclusively or almost exclusively in the patients were found. Functional correlates of the six variants identified were examined in cultured mammalian cells. We observed spindle pole defects during cell division and partially disrupted localization of UPF1, a protein involved in cell cycle regulation, at the spindles. Our observations provide insights into the genetic basis of HWE and suggest the involvement of hitherto unanticipated molecular process in this disorder.


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