Molecular cytogenetic evidence to characterize breakpoint regions in Robertsonian translocations

1990 ◽  
Vol 54 (3-4) ◽  
pp. 97-102 ◽  
Author(s):  
S.W. Cheung ◽  
L. Sun ◽  
T. Featherstone
Keyword(s):  
Robertsonian Translocations ◽  
Molecular Cytogenetic ◽  
Cytogenetic Evidence

scholarly journals Chromosome Translocations as a Driver of Diversification in Mole Voles Ellobius (Rodentia, Mammalia)

2019 ◽  
Vol 20 (18) ◽  
pp. 4466 ◽  
Author(s):  
Svetlana A. Romanenko ◽  
Elena A. Lyapunova ◽  
Abdusattor S. Saidov ◽  
Patricia C.M. O’Brien ◽  
Natalia A. Serdyukova ◽  
...  
Keyword(s):  
Diploid Number ◽  
Chromosomal Translocations ◽  
Subterranean Rodents ◽  
Hybrid Zones ◽  
Reciprocal Translocations ◽  
Robertsonian Translocations ◽  
Molecular Cytogenetic ◽  
Chromosome Translocations ◽  
Monobrachial Homology ◽  
Strong Barrier

The involvement of chromosome changes in the initial steps of speciation is controversial. Here we examine diversification trends within the mole voles Ellobius, a group of subterranean rodents. The first description of their chromosome variability was published almost 40 years ago. Studying the G-band structure of chromosomes in numerous individuals revealed subsequent homologous, step-by-step, Robertsonian translocations, which changed diploid numbers from 54 to 30. Here we used a molecular cytogenetic strategy which demonstrates that chromosomal translocations are not always homologous; consequently, karyotypes with the same diploid number can carry different combinations of metacentrics. We further showed that at least three chromosomal forms with 2n = 34 and distinct metacentrics inhabit the Pamir-Alay mountains. Each of these forms independently hybridized with E. tancrei, 2n = 54, forming separate hybrid zones. The chromosomal variations correlate slightly with geographic barriers. Additionally, we confirmed that the emergence of partial or monobrachial homology appeared to be a strong barrier for hybridization in nature, in contradistinction to experiments which we reported earlier. We discuss the possibility of whole arm reciprocal translocations for mole voles. Our findings suggest that chromosomal translocations lead to diversification and speciation.

scholarly journals Flying lemurs – The 'flying tree shrews'? Molecular cytogenetic evidence for a Scandentia-Dermoptera sister clade

BMC Biology ◽  
2008 ◽  
Vol 6 (1) ◽  
pp. 18 ◽  
Author(s):  
Wenhui Nie ◽  
Beiyuan Fu ◽  
Patricia CM O'Brien ◽  
Jinhuan Wang ◽  
Weiting Su ◽  
...  
Keyword(s):  
Tree Shrews ◽  
Molecular Cytogenetic ◽  
Sister Clade ◽  
Cytogenetic Evidence

Distribution of Telomeric Sequences (TTAGGG)n in Rearranged Chromosomes of Phyllotine Rodents (Cricetidae, Sigmodontinae)

2015 ◽  
Vol 147 (4) ◽  
pp. 247-252 ◽  
Author(s):  
Cecilia Lanzone ◽  
Carolina Labaroni ◽  
Natalia Suárez ◽  
Daniela Rodríguez ◽  
Macarena L. Herrera ◽  
...  
Keyword(s):  
Sex Chromosomes ◽  
Chromosomal Evolution ◽  
Robertsonian Translocations ◽  
Telomeric Sequences ◽  
Molecular Cytogenetic ◽  
Interstitial Telomeric Sequences ◽  
Robertsonian Rearrangements ◽  
Recent Origin ◽  
Chromosome Fusions ◽  
Molecular Cytogenetic Techniques

Phyllotines are sigmodontine rodents endemic to South America with broad genetic variability, Robertsonian polymorphisms being the most frequent. Moreover, this taxon includes a species with multiple sex chromosomes, which is infrequent in mammals. However, molecular cytogenetic techniques have never been applied to phyllotines to elucidate their karyotypic evolution. We studied the chromosomes of 4 phyllotine species using FISH with a pantelomeric probe (TTAGGG)n. Graomys griseoflavus, Eligmodontia puerulus, and E. morgani are polymorphic for Robertsonian translocations, whereas Salinomys delicatus possesses XX/ XY1Y2 sex chromosomes. Telomeric signals were detected at both ends of all chromosomes of the studied species. In S. delicatus interstitial telomeric sequences (ITS) were observed in the 3 major chromosome pairs, which are equidistant from one of the telomeres in these chromosomes. These results suggest that ITS are important in the reshuffling of the highly derived karyotype of S. delicatus. Considering the phylogeny of phyllotines, the Robertsonian rearrangements of G. griseoflavus, E. puerulus, and E. morgani possibly represent chromosome fusions which have occurred independently. The pericentromeric regions of the biarmed chromosomes of these species do not contain telomeric sequences characteristic for strict fusions of recent origin, suggesting a common pattern of telomeric repeat loss during chromosomal evolution of these rodents.

scholarly journals Molecular Cytogenetic Evidence for a Common Breakpoint in the Largest Inverted Duplications of Chromosome 15

1998 ◽  
Vol 62 (4) ◽  
pp. 925-936 ◽  
Author(s):  
A.E. Wandstrat ◽  
J. Leana-Cox ◽  
L. Jenkins ◽  
S. Schwartz
Keyword(s):  
Chromosome 15 ◽  
Molecular Cytogenetic ◽  
Cytogenetic Evidence

Frequency of USP6 rearrangements in myositis ossificans, brown tumor, and cherubism: molecular cytogenetic evidence that a subset of “myositis ossificans-like lesions” are the early phases in the formation of soft-tissue aneurysmal bone cyst

2008 ◽  
Vol 37 (4) ◽  
pp. 321-327 ◽  
Author(s):  
William R. Sukov ◽  
Marcello F. Franco ◽  
Michele Erickson-Johnson ◽  
Margaret M. Chou ◽  
K. Krishnan Unni ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Aneurysmal Bone Cyst ◽  
Myositis Ossificans ◽  
Bone Cyst ◽  
Brown Tumor ◽  
Molecular Cytogenetic ◽  
Cytogenetic Evidence ◽  
Early Phases

Cytogenetic and molecular cytogenetic evidence of recurrent 8q24.1 loss in osteochondroma

2002 ◽  
Vol 137 (2) ◽  
pp. 102-107 ◽  
Author(s):  
Michael G Feely ◽  
Amber K Boehm ◽  
Robert S Bridge ◽  
Pamela A Krallman ◽  
James R Neff ◽  
...  
Keyword(s):  
Molecular Cytogenetic ◽  
Cytogenetic Evidence

scholarly journals Molecular Cytogenetic Evidence of Rearrangements on the Y Chromosome of the Threespine Stickleback Fish

Genetics ◽  
2008 ◽  
Vol 179 (4) ◽  
pp. 2173-2182 ◽  
Author(s):  
Joseph A. Ross ◽  
Catherine L. Peichel
Keyword(s):  
Y Chromosome ◽  
Threespine Stickleback ◽  
Molecular Cytogenetic ◽  
Cytogenetic Evidence
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