Characterization of Cytoplasmic Inclusions Formed during Influenza/WSN Virus Infection of Chick Embryo Fibroblast Cells

Intervirology ◽  
1977 ◽  
Vol 8 (5) ◽  
pp. 281-293 ◽  
Author(s):  
Mary P. Morrongiello ◽  
Samuel Dales
Keyword(s):  
Chick Embryo ◽  
Virus Infection ◽  
Fibroblast Cells ◽  
Chick Embryo Fibroblast ◽  
Cytoplasmic Inclusions

Interferon Action:Effect on the Formation of Poxvirus Specific Polysomes and Viral RNA

1970 ◽  
Vol 25 (10) ◽  
pp. 1164-1170 ◽  
Author(s):  
I. Horak ◽  
J. Hilfenhaus ◽  
W. Siegert ◽  
C. Jungwirth ◽  
G. Bodo ◽  
...  
Keyword(s):  
Chick Embryo ◽  
Viral Rna ◽  
Fibroblast Cells ◽  
Cowpox Virus ◽  
Chick Embryo Fibroblast ◽  
L Cells ◽  
Chicken Fibroblast

Treatment of chick embryo fibroblast cells or mouse L-cells with homologous interferon resulted in a reduced formation of poxvirus specific polysomes and of viral RNA. In chick cells infected with cowpox virus the reduced formation of viral polysomes and virus-specific RNA after pretreatment of cells with interferon was observed at all timepoints studied (1 - 6 hours p. i.). Exposure of cells to poly I: poly C caused a similar effect. In mouse L-cells infected with vaccinia WR virus pretreatment with interferon did not result in a reduced formation of viral polysomes or virus-specific RNA up to 1 hour p. i. At about 45 min even a slight increase of the formation of viral polysomes and RNA was observed. At later stages of infection (2 -4 hours p. i.) a reduced synthesis of viral polysomes and RNA was seen, similar to that found in the chicken fibroblast system.

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