Inhibition of Human Platelet Aggregation by the Proteolytic Effect of Streptokinase Role of the Human Factor-VIII-Related Protein

1976 ◽  
Vol 5 (5) ◽  
pp. 306-317
Author(s):  
Ricardo Castillo ◽  
Santiago Maragall ◽  
Javier Alvarez Guisasola ◽  
Francisco Casals ◽  
Juan Profitós ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Factor Viii ◽  
Human Factor ◽  
Human Platelet ◽  
Related Protein ◽  
Human Platelet Aggregation ◽  
Human Factor Viii

scholarly journals Inhibition of Human Platelet Aggregation by Plasmin Digests of Human Factor VIII

Blood ◽  
1973 ◽  
Vol 42 (5) ◽  
pp. 749-751 ◽  
Author(s):  
M. B. Donati ◽  
G. de Gaetano ◽  
J. Vermylen ◽  
M. Verstraete
Keyword(s):  
Platelet Aggregation ◽  
Factor Viii ◽  
Human Factor ◽  
Human Platelet ◽  
Hemorrhagic Diathesis ◽  
Thrombin Time ◽  
Prolonged Incubation ◽  
Human Platelet Aggregation ◽  
Human Factor Viii

Abstract Human factor VIII, upon prolonged incubation at 37°C with plasmin, inhibits platelet aggregation induced by ADP, adrenaline, or collagen. The human factor VIII digests are not anticoagulant in the thrombin time or partial thromboplastin time. Factor VIII split products may interfere in vivo with platelet function and thus could contribute in some way to the hemorrhagic diathesis of fibrinolytic states.

59 Role of phosphatidylinositol 3-kinase in human platelet aggregation

1997 ◽  
Vol 25 (4) ◽  
pp. S600-S600 ◽  
Author(s):  
BUKHTIAR H. SHAH ◽  
SHEIKH A. SAEED ◽  
GAZALA SHAMIM ◽  
ZAFAR NAWAZ ◽  
ANWAR H. GILANI
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Phosphatidylinositol 3 Kinase ◽  
Human Platelet Aggregation ◽  
Phosphatidylinositol 3

scholarly journals Studies of the human factor VIII/von Willebrand's factor protein. II. Identification and characterization of the von Willebrand protein

Blood ◽  
1975 ◽  
Vol 46 (3) ◽  
pp. 417-430
Author(s):  
HR Gralnick ◽  
BS Coller
Keyword(s):  
Factor Viii ◽  
Human Factor ◽  
Polyacrylamide Gel Electrophoresis ◽  
Gel Filtration ◽  
Related Protein ◽  
Human Factor Viii ◽  
Von Willebrand’S Factor ◽  
Von Willebrand ◽  
Identification And Characterization

The purified factor VIII-related protein we have previously characterized from normal cryoprecipitate possesses both procoagulant activity and vWf activity. We have attempted to isolate and characterize this protein from three patients with severe vWd. This protein is absent or markedly diminished in amount in these vWd patients, as judged by gel filtration, polyacrylamide-gel electrophoresis, and immunoprecipitation assays. Likewise, the procoagulant and vWf activities are deficient. As vWf activity is one of the major biologic functions of either the normal or hemophilic factor VIII-related protein, the purified protein should be designated the f VIII/vWf protein.

scholarly journals Role of chondroitin 4-sulphate as a receptor for polycation induced human platelet aggregation

1996 ◽  
Vol 119 (7) ◽  
pp. 1447-1453 ◽  
Author(s):  
José L. Donato ◽  
Sisi Marcondes ◽  
Edson Antunes ◽  
Marie D. Nogueira ◽  
Helena B. Nader ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Human Platelet Aggregation
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