KLOTHO Gene Polymorphisms G-395A and C1818T Are Associated with Low-Density Lipoprotein Cholesterol and Uric Acid in Japanese Hemodialysis Patients

2009 ◽  
Vol 30 (4) ◽  
pp. 383-388 ◽  
Author(s):  
Yasuhiko Shimoyama ◽  
Kentaro Taki ◽  
Yoko Mitsuda ◽  
Yoshinari Tsuruta ◽  
Nobuyuki Hamajima ◽  
...  
2008 ◽  
Vol 28 (9) ◽  
pp. 423-426 ◽  
Author(s):  
Renata L. Miranda ◽  
Antonio V. Mundim ◽  
Álisson S. Costa ◽  
Ruyther V. Guimarães ◽  
Frederico O.C. Silva

An analysis was made of 30 four-day-old ostriches to evaluate their protein, metabolite, mineral, and serum enzyme profiles, to correlate them with the birds' sex. The values obtained were: Total proteins 3.59±0.72g/dL, albumin 1.04±0.14g/dL, globulins 2.51±0.56g/dL, A:G ratio 0.43± 0.07, total cholesterol 615.10±101.15mg/dL, high density lipoprotein cholesterol (HDL-C) 132.72±20.33mg/dL, low density lipoprotein cholesterol (LDL-C) 454.93±90.81mg/dL, very low density lipoprotein cholesterol (VLDL-C) 27.45±9.96mg/dL, triglycerides 137.23±49.78mg/dL, uric acid 6.24±2.15mg/dL, urea 18.27±12.33mg/dL, creatinine 0.30±0.04mg/dL, total calcium 9.38± 0.76mg/dL, ionized calcium 7.17±0.64mg/dL, phosphorus 6.96±0.91mg/dL, Ca:P ratio 1.37±0.21, iron 24.74±13.02µg/dL, sodium 142.03±6.17mEq/L, chlorides 109.59± 4.99mEq/L, aspartate aminotransferase (AST) 200.67±31.42 U/L, alanine aminotransferase (ALT) 3.90±1.92 U/L, γ-glutamyltransferase (GGT) 1.18±0.73 U/L, alkaline phosphatase (ALP) 597.30± 231.36 U/L, and creatine kinase (CK) 2348.30±755.60 U/L. Males and females showed significant differences in total proteins, globulins, alkaline phosphatase, A:G ratio, and uric acid.


2005 ◽  
Vol 23 (2) ◽  
pp. 134-140 ◽  
Author(s):  
Chih-Kang Chiang ◽  
Tai-I Ho ◽  
Shih-Ping Hsu ◽  
Yu-Sen Peng ◽  
Mei-Fen Pai ◽  
...  

2008 ◽  
Vol 33 (4) ◽  
pp. 761-768 ◽  
Author(s):  
Kevin C.M. Wood ◽  
Morgan D. Fullerton ◽  
Ahmed El-Sohemy ◽  
Marica Bakovic

The purpose of this study was to assess the individual and interactive effects between hepatic lipase (LIPC; C-514T, G-250A) and apolipoprotein E (APOE) (E2, E3, E4) gene polymorphisms on levels of plasma lipoprotein cholesterol and triglyceride among healthy, young, Canadian adults (n = 440). All subjects with at least one APOE2 allele had significantly lower low-density lipoprotein cholesterol, total cholesterol, and total cholesterol – high-density lipoprotein cholesterol ratio when compared with those with the APOE3 or APOE4 allele. There were significant differences in the LIPC allele and genotype frequencies between Caucasian (n = 207) and Asian (n = 211) individuals, but ethnicity did not contribute to the variations in circulating lipids. In addition, the lowest triglyceride levels (0.87 ± 0.27 mmol·mL–1) were found in all APOE2 individuals carrying LIPC-514-CC and LIPC-250-GG genotypes, whereas the highest triglyceride levels (1.29 ± 0.34 –1.32 ± 0.32 mmol·mL–1) were found in APOE2 individuals carrying the opposite genotypes, LIPC-514TT and LIPC-250AA. These observations, distinct from the anti-atherogenic effects of APOE2 through the lowering of low-density lipoprotein cholesterol and LIPC on high-density lipoprotein cholesterol, suggest that there is an interactive effect between APOE and LIPC genotypes on plasma triglyceride levels. These results provide the basis for further studies on establishing which genotype combinations would be the most protective against hypertriglyceridemia.


2004 ◽  
Vol 37 (10) ◽  
pp. 937-940 ◽  
Author(s):  
Eleni T. Bairaktari ◽  
Christos Tzallas ◽  
M. Kalientzidou ◽  
Alexandros D. Tselepis ◽  
Kostas C. Siamopoulos ◽  
...  

2001 ◽  
Vol 34 (8) ◽  
pp. 593-602 ◽  
Author(s):  
Eleni Bairaktari ◽  
Moses Elisaf ◽  
Christos Tzallas ◽  
Sonia Anna Karabina ◽  
Alexandros D. Tselepis ◽  
...  

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