B-Cell Chronic Lymphocytic Leukemia Associated with High Serum IGE Levels and Pruriginous Skin Lesions: Successful Therapy with IFN-α2b after Failure on IFN-γ

Dermatology ◽  
1996 ◽  
Vol 192 (2) ◽  
pp. 110-115 ◽  
Author(s):  
K. Neuber ◽  
B. Berg-Drewniock ◽  
M. Volkenandt ◽  
M. Neumaier ◽  
W. Zeller ◽  
...  
2018 ◽  
pp. 92-96
Author(s):  
S. R. Goryacheva ◽  
T. V. Sorokina ◽  
L. S. Al-Radi ◽  
A. M. Sherstnev ◽  
T. N. Moiseeva

The description of the clinical observation of the successful therapy with ibrutinib recurrent B-cell chronic lymphocytic leukemia associated with autoimmune complications is given. The reasons for occurrence the autoimmune complications of CLL, their effect on the disease prognosis as well as the tactics of conducting similar patients have been considered.


2006 ◽  
Vol 12 (4) ◽  
pp. 187-192
Author(s):  
F. Scamardella ◽  
M. Maconi ◽  
L. Albertazzi ◽  
B. Gamberi ◽  
L. Gugliotta ◽  
...  

Author(s):  
Alessandro Pileri ◽  
Carlotta Baraldi ◽  
Alessandro Broccoli ◽  
Roberto Maglie ◽  
Annalisa Patrizi ◽  
...  

2001 ◽  
Vol 194 (11) ◽  
pp. 1639-1648 ◽  
Author(s):  
Andreas Rosenwald ◽  
Ash A. Alizadeh ◽  
George Widhopf ◽  
Richard Simon ◽  
R. Eric Davis ◽  
...  

The most common human leukemia is B cell chronic lymphocytic leukemia (CLL), a malignancy of mature B cells with a characteristic clinical presentation but a variable clinical course. The rearranged immunoglobulin (Ig) genes of CLL cells may be either germ-line in sequence or somatically mutated. Lack of Ig mutations defined a distinctly worse prognostic group of CLL patients raising the possibility that CLL comprises two distinct diseases. Using genomic-scale gene expression profiling, we show that CLL is characterized by a common gene expression “signature,” irrespective of Ig mutational status, suggesting that CLL cases share a common mechanism of transformation and/or cell of origin. Nonetheless, the expression of hundreds of other genes correlated with the Ig mutational status, including many genes that are modulated in expression during mitogenic B cell receptor signaling. These genes were used to build a CLL subtype predictor that may help in the clinical classification of patients with this disease.


2021 ◽  
Author(s):  
Francesca Magrinelli ◽  
Sara Mariotto ◽  
Gianpaolo Nadali ◽  
Giuseppe Todeschini ◽  
Massimiliano Lanzafame ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document