Umbilical Artery Doppler Waveform in Pregnancies with Uncomplicated Intra-Uterine Growth Retardation

1988 ◽  
Vol 26 (3) ◽  
pp. 206-210 ◽  
Author(s):  
N.G. Haddad ◽  
F.D. Johnstone ◽  
P.R. Hoskins ◽  
S.E. Chambers ◽  
B.B. Muir ◽  
...  
Keyword(s):  
Growth Retardation ◽  
Umbilical Artery ◽  
Doppler Waveform ◽  
Uterine Growth ◽  
Umbilical Artery Doppler ◽  
Intra Uterine Growth Retardation

scholarly journals Application of Umbilical Artery Classification in Complicated Monochorionic Twins

2015 ◽  
Vol 18 (5) ◽  
pp. 601-605 ◽  
Author(s):  
Lucia Pasquini ◽  
Silvia Conticini ◽  
Tiziana Tomaiuolo ◽  
Giovanni Sisti ◽  
Viola Seravalli ◽  
...  
Keyword(s):  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Umbilical Artery ◽  
Type I ◽  
Monochorionic Twins ◽  
Intrauterine Growth ◽  
Type Iii ◽  
Uterine Growth ◽  
Umbilical Artery Doppler ◽  
Intra Uterine Growth Retardation

We report our experience on the application of Gratacos’ classification in a cohort of monochorionic pregnancies complicated by selective intra-uterine growth retardation based on the Doppler assessment of the umbilical artery. Materials and methods: A retrospective study was conducted on 52 cases of monochorionic twin pregnancies, in which one twin presented an abdominal circumference at or below the 10th percentile for gestational age. Cases were classified into three types according to the umbilical artery Doppler in the smaller twin. Subsequently, patients were divided into two groups: the selective IntraUterine Growth Retardation group and the Twin-to-Twin Transfusion Syndrome (TTTS) group. Results: Of the total 52 cases, 37 were classified as Type I, 12 as Type II, and 3 as Type III cases. In the total group, progressive fetal deterioration of the smaller fetus requiring active management was observed in 66.7% of Type II and 11.1% of Type I cases (p < .001), and in no Type III case. Unexpected fetal death of the smaller twin was observed more frequently in Type III (two cases, 66.7%) than in Types I and II cases (5% and 33%, respectively). Among the 52 cases, TTTS with oligo-polyhydramnios sequence was diagnosed in 10 cases. The remaining 42 cases were therefore defined as selective intra-uterine growth retardation. In the selective IntraUterine Growth Retardation group, results were similar to those obtained for the whole population. Conclusions: Classification of complicated monochorionic twins based on the umbilical artery Doppler is particularly important for counseling, even when we include TTTS cases, and permits the prediction of clinical evolution and perinatal outcome.

scholarly journals Effects of prenatal glucocorticoid exposure on cardiac calreticulin and calsequestrin protein expression during early development and in adulthood

2003 ◽  
Vol 371 (1) ◽  
pp. 61-69 ◽  
Author(s):  
Maria L. LANGDOWN ◽  
Mark J. HOLNESS ◽  
Mary C. SUGDEN
Keyword(s):  
Cardiac Function ◽  
Protein Expression ◽  
Growth Retardation ◽  
Premature Death ◽  
Fetal Life ◽  
Dexamethasone Treatment ◽  
Increased Risk ◽  
Uterine Growth ◽  
Intra Uterine Growth Retardation ◽  
Glucocorticoid Action

Overexpression of the conserved Ca2+-binding proteins calreticulin and calsequestrin impairs cardiac function, leading to premature death. Calreticulin is vital for embryonic development, but also impairs glucocorticoid action. Glucocorticoid overexposure during late fetal life causes intra-uterine growth retardation and programmed hypertension in adulthood. To determine whether intra-uterine growth retardation or programmed hypertension was associated with altered calreticulin or calsequestrin expression, effects of prenatal glucocorticoid overexposure (maternal dexamethasone treatment on days 15—21 of pregnancy) were examined during fetal life and postnatal development until adulthood (24 weeks). Dexamethasone (100 or 200μg/kg of maternal body weight) was administered via osmotic pump. Calreticulin was detected as a 55kDa band and calsequestrin as 55 and 63kDa bands in 21 day fetal hearts. Only the 55kDa calsequestrin band was detected postnatally. Prenatal glucocorticoid overexposure at the higher dose decreased calreticulin protein expression (26%; P<0.05) but increased calsequestrin protein expression, both 55 and 63kDa bands, by 87% (P<0.01) and 78% (P<0.01); only the 55kDa calsequestrin band was increased at the lower dose (66%; P<0.05). Offspring of dams treated at the lower dexamethasone dose were studied further. In control offspring, cardiac calreticulin protein expression declined between 2 and 3 weeks of age, and remained suppressed until adulthood. Cardiac calsequestrin protein expression increased 2-fold between fetal day 21 and postnatal day 1 and continued to increase until adulthood, at which time it was 3.4-fold higher (P<0.001). Prenatal dexamethasone exposure minimally affected postnatal calsequestrin protein expression, but the postnatal decline in calreticulin protein expression was abrogated and calreticulin protein expression in adulthood was 2.2-fold increased (P<0.001) compared with adult controls. In view of the known associations between cardiac calreticulin overexpression and impaired cardiac function, targeted up-regulation of calreticulin may contribute to the increased risk of adult heart disease introduced as a result of prenatal overexposure to glucocorticoids.

Association of increased maternal ferritin levels with gestational diabetes and intra-uterine growth retardation

2010 ◽  
Vol 36 (1) ◽  
pp. 58-63 ◽  
Author(s):  
V. Soubasi ◽  
S. Petridou ◽  
K. Sarafidis ◽  
Ch. Tsantali ◽  
E. Diamanti ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Growth Retardation ◽  
Uterine Growth ◽  
Intra Uterine Growth Retardation

Tyrosine α ketoglutarate transaminase in the liver of rats with intra-uterine growth retardation

Life Sciences ◽  
1971 ◽  
Vol 10 (19) ◽  
pp. 1115-1123
Author(s):  
C. Degremont ◽  
J.M. Roux ◽  
E. Swierczewski ◽  
C. Tordet-Caridroit
Keyword(s):  
Growth Retardation ◽  
Uterine Growth ◽  
Intra Uterine Growth Retardation

Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas

2003 ◽  
Vol 81 (3) ◽  
pp. 257-262 ◽  
Author(s):  
J.B. Sharma ◽  
Ashok Kumar ◽  
A. Kumar ◽  
M. Malhotra ◽  
R. Arora ◽  
...  
Keyword(s):  
Growth Retardation ◽  
Uterine Growth ◽  
Intra Uterine Growth Retardation
Sign in / Sign up

Export Citation Format

Share Document