Premature Death
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Cancer ◽  
2021 ◽  
Author(s):  
Freddie Bray ◽  
Mathieu Laversanne ◽  
Elisabete Weiderpass ◽  
Isabelle Soerjomataram
Keyword(s):  

2021 ◽  
Author(s):  
Wenjing Ye ◽  
Weiwei Lu ◽  
Yibo Ding ◽  
Yichen Chen ◽  
Lin Wang ◽  
...  

Abstract Background: Lung cancer is a leading cause of deaths worldwide, and its incidence shows an upward trend. The study in the long-term changes in premature death of lung cancer in a developed region of China has a great exploratiory significance to further clarify the effectiveness of intervention measures.Methods: Cancer death data were collected from the Mortality Registration System of Shanghai Pudong New Area (PNA). We analysed crude mortality rate (CMR), age-standardized mortality rate by Segi’s world standard population (ASMRW), and years of life lost (YLL) of lung cancer from 1973 to 2019. Temporal trends of CMR, ASMRW, and rate of YLL were calculated by joinpoint regression expressed as an annual percent change (APC) with corresponding 95% confidence interval.Results: 80,543,137 person-years were enrolled in this study in PNA from 1973 to 2019. There were 42,229 deaths in permanent residents from lung cancer. The CMR and ASMRW were 52.43/105 person-years and 27.79/105 person-years. YLL due to premature death from lung cancer was 481779.14 years, and the rate of YLL was 598.16/105 person-years. The CMR, and rate of YLL for deaths had significantly increasing trends in males, females, and the total population (P<0.001). The CMR in the total population increased by 2.86% (95% CI=2.66%-3.07%, P < 0.001) per year during the study period. The YLL rate increased with an APCC of 2.21% (95% CI = 1.92% to 2.51%, P < 0.001) per year. The contribution rates of increased values of CMR caused by demographic factors were more evident than non-demographic factors.Conclusion: The aging population, progress of treatment, smoking, and even environmental pollution may be the factors that affect the long-term changes in premature death of lung cancer in PNA from1973 to 2019. Our research can help us to understand the changes of lung cancer mortality, and our results could also be used for other similar cities in designing future prevention plans.


2021 ◽  
Vol 16 (2) ◽  
pp. 111
Author(s):  
Brigitte Sarah Renyoet

Millions of children and adolescents in Indonesia today still show a high number of premature death in children who are moderately malnourished and severely malnourished. The research objective was to calculate the estimated economic losses potential due to underweight among toddlers in Indonesia. This was a descriptive research by analyzing secondary data of nutritional status and socio-economic indicators in 2013 from the Indonesian Ministry of Health and Central Statistical Agency. The formula to calculate potential economic loss is based on Konig’s formula (1995) and the correction factor from research by Horton (1999). The results showed that the average economic loss in 32 provinces in Indonesia is approximately IDR 93 billion – IDR 417 billion, which seen from the GRDP percentage, the economic loss due to a decrease in productivity amounted to 2% and 9% or about 0.1–0.7% of the average GRDP of the provinces in Indonesia. Nationally, economic losses due to low productivity in underweight toddlers reach IDR 3,054 billion – IDR 13,746 billion (0.04–0.2%) of Indonesia’s total GDP. The results of this study are expected to show that the importance of this issue was handled and can assist the government in planning for health and nutrition programs targeted to human resources in Indonesia qualifi ed and productive.


PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11485
Author(s):  
Peter R.T. Bowman ◽  
Godfrey L. Smith ◽  
Gwyn W. Gould

The global incidence, associated mortality rates and economic burden of diabetes are now such that it is considered one of the most pressing worldwide public health challenges. Considerable research is now devoted to better understanding the mechanisms underlying the onset and progression of this disease, with an ultimate aim of improving the array of available preventive and therapeutic interventions. One area of particular unmet clinical need is the significantly elevated rate of cardiomyopathy in diabetic patients, which in part contributes to cardiovascular disease being the primary cause of premature death in this population. This review will first consider the role of metabolism and more specifically the insulin sensitive glucose transporter GLUT4 in diabetic cardiac disease, before addressing how we may use exercise to intervene in order to beneficially impact key functional clinical outcomes.


2021 ◽  
Author(s):  
Hongying Hao ◽  
Lizheng Xu ◽  
Anli Leng ◽  
Jingjie Sun ◽  
Nicholas Stephen ◽  
...  

Abstract Objective: To provide the first estimates of the cost of productivity losses attributed to diabetes age 20-69 years old in urban and rural areas of China. Methods: Construct through life table modelling, expectancy life of diabetes sufferers, including the years of potential life lost and working years of life lost. Using the human capital approach, we measured the productivity losses attributed to absenteeism, presenteeism, labor force dropout and premature deaths due to diabetes of the population aged 20-69 years in urban and rural areas in China. Results: In 2017, we estimated that there were 100.46 million diabetes lost hours, with the total cost of productivity losses US$613.60 billion, comprising US$326.40 billion from labor force dropout, US$186.34 billion from premature death, US$97.71 billion from absenteeism, and US$27.04 billion from presenteeism. Productivity loss was greater in urban (US$490.79 billion) than rural areas (US$122.81 billion), with urban presenteeism (US$2.54 billion) greater than rural presenteeism (US$608.55 million); urban absenteeism (US$79.10 billion) greater than rural absenteeism (US$18.61 billion); urban labour force dropout (US$261.24 billion) greater than rural labour force dropout (US$65.15 billion) and urban premature death (US$147.90 billion) greater than rural premature death (US$38.44 billion). Conclusions: Diabetes had a large and significant negatively impact on productivity in urban and rural in China, with a significant gap in the level of diabetes management in urban compared to rural regions. Productivity loss was significantly higher in urban than rural regions. Further investment is required in the prevention, diagnosis and control of diabetes in under-resourced health services in rural locations and also in urban areas, where most diabetes cases reside. Specifically, targeted and effective diabetes prevention and management actions are urgently required.


2021 ◽  
Author(s):  
Deon Bridge

Particulate matter from fireworks events are poorly understood sources of PM2.5 despite their potential to add significant quantities of PM2.5 to the atmosphere. PM2.5 has been found to aggravate various cardiovascular and respiratory illnesses and has been linked to premature death. Each year La Ronde amusement park on Sainte-Helene Island exhibits numerous firework events in what is considered one of the world's premiere pyrotechnic competitions. These individual events are the centre of study for this project. Each event was modelled using Lakes Environmental's version of AERMOD, which estimated PM2.5 concentration plumes which then underwent geospatial analysis using ArcMap. This project details the PM2.5 plume dynamics from La Ronde fireworks events from 1990-2004, and how these events impact a ten kilometer radius around the island of Sainte-Helene in Montreal, Canada.


2021 ◽  
Author(s):  
Deon Bridge

Particulate matter from fireworks events are poorly understood sources of PM2.5 despite their potential to add significant quantities of PM2.5 to the atmosphere. PM2.5 has been found to aggravate various cardiovascular and respiratory illnesses and has been linked to premature death. Each year La Ronde amusement park on Sainte-Helene Island exhibits numerous firework events in what is considered one of the world's premiere pyrotechnic competitions. These individual events are the centre of study for this project. Each event was modelled using Lakes Environmental's version of AERMOD, which estimated PM2.5 concentration plumes which then underwent geospatial analysis using ArcMap. This project details the PM2.5 plume dynamics from La Ronde fireworks events from 1990-2004, and how these events impact a ten kilometer radius around the island of Sainte-Helene in Montreal, Canada.


Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2927
Author(s):  
Nikitas Georgiou ◽  
Vasileios K. Gkalpinos ◽  
Spyridon D. Katsakos ◽  
Stamatia Vassiliou ◽  
Andreas G. Tzakos ◽  
...  

Hypertension is one of the most common diseases nowadays and is still the major cause of premature death despite of the continuous discovery of novel therapeutics. The discovery of the Renin Angiotensin System (RAS) unveiled a path to develop efficient drugs to fruitfully combat hypertension. Several compounds that prevent the Angiotensin II hormone from binding and activating the AT1R, named sartans, have been developed. Herein, we report a comprehensive review of the synthetic paths followed for the development of different sartans since the discovery of the first sartan, Losartan.


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