Loss-of-Function Mutations within the Filaggrin Gene and Atopic Dermatitis

Author(s):  
Hiroshi Kawasaki ◽  
Akiharu Kubo ◽  
Takashi Sasaki ◽  
Masayuki Amagai
2021 ◽  
Vol 11 (11) ◽  
pp. 115-123
Author(s):  
Mousumi Das

Atopic dermatitis is a common, chronic, intensely pruritic, relapsing inflammatory skin disease that affects both children and adults. Atopic dermatitis is often the originating of a series of allergic disorders, mentioned as the "atopic march".There are numerous risk factors correlated with AD development. However, only two have always been related, and they are (1) family history of atopy and (2) loss of function mutations in the FLG gene. Topical anti-inflammatory therapy with topical corticosteroids or topical calcineurin inhibitors treatment are available in conventional therapy but sometimes it has been reported that patients are also benefited from Homoeopathic treatment. Four patients who presented at the outpatient department at National Institute of Homoeopathy, Saltlake, Kolkata with Atopic dermatitis and a family history of asthma, allergic rhinitis were treated with constitutional homoeopathic medicine. Details of consultations, treatment and assessment are summarized. A constitutional treatment thus eliminates the symptoms locally and internally as well as long-lasting relief from complaints. Common remedies include Mercuris Solubilis, Sulphur. This case series shows positive results of homoeopathy in the treatment of Atopic dermatitis. Key words: Atopic dermatitis, Family history, Individualized Homoeopathic treatment, Case series, repertorisation.


2019 ◽  
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pp. 58-60
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Emi Yamazaki ◽  
Katsuko Kikuchi ◽  
Yoji Sasahara ◽  
Michihiro Kono ◽  
Masashi Akiyama ◽  
...  

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Vol 155 (5) ◽  
pp. 1093-1094 ◽  
Author(s):  
A. Ruether ◽  
M. Stoll ◽  
T. Schwarz ◽  
S. Schreiber ◽  
R. Fölster-Holst

PEDIATRICS ◽  
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pp. S123-S123
Author(s):  
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Cecilia P. Mikita

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Vol 31 (6) ◽  
pp. 1038-1043 ◽  
Author(s):  
Y.M.F. Andersen ◽  
A. Egeberg ◽  
E. Balslev ◽  
C.L.T. Jørgensen ◽  
P.B. Szecsi ◽  
...  

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