Clinical Efficacy and Safety in Children with Vesicoureteral Reflux of a Single Injection of Two Different Bulking Agents – Polydimethylsiloxane (Macroplastique) or Dextranomer/Hyaluronic Acid Copolymer (Deflux): A Short-Term Prospective Comparative Study

Endoscopic treatment for vesicoureteral reflux (VUR) has become an established alternative to long-term antibiotic prophylaxis and ureteral reimplantation. We present the outcome of endoscopic treatment with dextranomer/hyaluronic acid copolymer (Deflux) for VUR in children by a single surgeon at our institute from October 2003 to October 2009. We reviewed the cases of 150 patients (total 239 ureters), 56 girls (37%) and 94 boys (63%), with a mean age of 2.2 years and a median followup of 2.5 years (range 3–68 months). Among the 239 ureters treated, 67.4% (161/239) were cured with a single injection, and a second and third injection raised the cure rate to 86.6% (207/239) and 88.3% (211/239), respectively. None had postoperative ureteral obstruction.

Download Full-text

PROSPECTIVE COMPARATIVE STUDY OF POLYDIMETHYLSILOXANE VS HYALURONIC ACID INJECTION FOR TREATMENT OF VESICOURETERAL REFLUX

The Journal of Urology ◽

10.1016/s0022-5347(08)60583-2 ◽

2008 ◽

Vol 179 (4S) ◽

pp. 201-201 ◽

Cited By ~ 1

Author(s):

Katherine Moore ◽

Stephane Bolduc

Keyword(s):

Hyaluronic Acid ◽

Comparative Study ◽

Vesicoureteral Reflux ◽

Hyaluronic Acid Injection ◽

Acid Injection ◽

Prospective Comparative Study

Download Full-text

Can We Rely on the Presence of Dextranomer-Hyaluronic Acid Copolymer Mounds on Ultrasound to Predict Vesicoureteral Reflux Resolution After Injection Therapy?

Ultrasound Quarterly ◽

10.1097/01.ruq.0000409896.23170.c2 ◽

2011 ◽

Vol 27 (4) ◽

pp. 272

Author(s):

Yoshimi Endo

Keyword(s):

Hyaluronic Acid ◽

Vesicoureteral Reflux ◽

Injection Therapy ◽

Acid Copolymer

Download Full-text

Efficacy and Safety of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild-to-Moderate Acne Vulgaris: A Comparative Study

Dermatology Practical & Conceptual ◽

10.5826/dpc.1103a63 ◽

2021 ◽

pp. 2021063

Author(s):

Surabhi Dayal ◽

Satbir Singh ◽

Priyadarshini Sahu

Keyword(s):

Salicylic Acid ◽

Adverse Effects ◽

Comparative Study ◽

Clinical Efficacy ◽

Trichloroacetic Acid ◽

Acne Vulgaris ◽

Efficacy And Safety ◽

Inflammatory Lesions ◽

Treatment Groups ◽

Proven Efficacy

Background: Both salicylic acid (SA) and trichloroacetic acid (TCA) have proven efficacy with goodsafety profiles in the treatment of acne vulgaris. Objectives: This study compared the clinical efficacy and safety of 25% TCA and 30% SA peels in thetreatment of mild and moderate acne vulgaris. Methods: Patients with mild or moderate acne vulgaris were randomized into 2 groups of 25 personseach, and treated with either the TCA peel or the SA peel at 2-week intervals for 12 weeks. Evaluationof active acne was done by individual lesion counts (comedones, papules and pustules) and calculationof the Michaelsson acne score (MAS). Results: Both peels led to significant decrease in individual lesion counts and MAS compared to baselinevalues, without significant differences between the treatment groups. Thus, the peels had equivalentefficacy against acne vulgaris. The TCA peel was better in treating non-inflammatory lesions,while the SA peel was better for inflammatory lesions, but the differences were not significant. Noserious adverse effects were recorded, but more patients in the TCA peel group experienced burningand stinging sensations. Conclusion: The efficacy of 25% TCA is comparable to that of 30% SA in mild-to-moderate acnevulgaris, but safety and tolerability were better with the SA peel than TCA peel.

Download Full-text