scholarly journals Efficacy and Safety of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild-to-Moderate Acne Vulgaris: A Comparative Study

2021 ◽  
pp. 2021063
Author(s):  
Surabhi Dayal ◽  
Satbir Singh ◽  
Priyadarshini Sahu
Keyword(s):  
Salicylic Acid ◽  
Adverse Effects ◽  
Comparative Study ◽  
Clinical Efficacy ◽  
Trichloroacetic Acid ◽  
Acne Vulgaris ◽  
Efficacy And Safety ◽  
Inflammatory Lesions ◽  
Treatment Groups ◽  
Proven Efficacy

Background: Both salicylic acid (SA) and trichloroacetic acid (TCA) have proven efficacy with goodsafety profiles in the treatment of acne vulgaris. Objectives: This study compared the clinical efficacy and safety of 25% TCA and 30% SA peels in thetreatment of mild and moderate acne vulgaris. Methods: Patients with mild or moderate acne vulgaris were randomized into 2 groups of 25 personseach, and treated with either the TCA peel or the SA peel at 2-week intervals for 12 weeks. Evaluationof active acne was done by individual lesion counts (comedones, papules and pustules) and calculationof the Michaelsson acne score (MAS). Results: Both peels led to significant decrease in individual lesion counts and MAS compared to baselinevalues, without significant differences between the treatment groups. Thus, the peels had equivalentefficacy against acne vulgaris. The TCA peel was better in treating non-inflammatory lesions,while the SA peel was better for inflammatory lesions, but the differences were not significant. Noserious adverse effects were recorded, but more patients in the TCA peel group experienced burningand stinging sensations. Conclusion: The efficacy of 25% TCA is comparable to that of 30% SA in mild-to-moderate acnevulgaris, but safety and tolerability were better with the SA peel than TCA peel.

scholarly journals A COMPARATIVE STUDY OF THE EFFICACY AND SAFETY OF 12 % GLYCOLIC ACID CREAM AND 10% AZELAIC ACID CREAM IN THE TREATMENT OF POST ACNE HYPERPIGMENTATION.

2021 ◽  
pp. 34-35
Author(s):  
Archana Rede ◽  
Sanjay N. Agrawal ◽  
Yoganand Kulkarni
Keyword(s):  
Comparative Study ◽  
Azelaic Acid ◽  
Glycolic Acid ◽  
Acne Vulgaris ◽  
Inflammatory Disorder ◽  
Efficacy And Safety ◽  
Common Complication ◽  
Pilosebaceous Unit ◽  
Inflammatory Lesions ◽  
Chronic Inflammatory Disorder

Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that is associated with significant psychosocial repercussions. Post inflammatory hyperpigmentation is a most common complication seen after post acne. Therapeutic goal of treatment include promoting degradation of melanosomes and inhibiting their formation. Patient treated with Azelaic acid / Glycolic acid experienced of significant greater reduction in number of inflammatory lesions. This study focuses on the comparison of efficacy of 12% Glycolic acid and 10% Azelaic acid in treating post acne hyperpigmentation.

Jessner's solutionvs. 30% salicylic acid peels: a comparative study of the efficacy and safety in mild-to-moderate acne vulgaris

2016 ◽  
Vol 16 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Surabhi Dayal ◽  
Ashish Amrani ◽  
Priyadarshini Sahu ◽  
Vijay Kumar Jain
Keyword(s):  
Salicylic Acid ◽  
Comparative Study ◽  
Acne Vulgaris ◽  
Efficacy And Safety

scholarly journals Comparative study of clinical efficacy and safety of intrathecal isobaric ropivacaine 0.75% with fentanyl versus isobaric ropivacaine 0.75% alone for caesarean

2020 ◽  
Vol 7 (1) ◽  
pp. 1
Author(s):  
Pushpal Gandhi ◽  
Mahendra Agrawal ◽  
Bhavika Agrawal ◽  
Simarn Behl
Keyword(s):  
Caesarean Section ◽  
Adverse Effects ◽  
Comparative Study ◽  
Clinical Efficacy ◽  
Total Duration ◽  
Sensory Block ◽  
Hemodynamic Parameters ◽  
Efficacy And Safety ◽  
Physical Status ◽  
Significant Difference

<p><strong>Background: </strong>Compare the clinical efficacy and safety of intrathecal isobaric ropivacaine 0.75% with fentanyl, 10 mcg vs isobaric ropivacaine 0.75% alone for caesarean section.</p><p><strong>Methods: </strong>Two hundred patients were considered eligible for the study of which one hundred and sixty-eight patients undergoing caesarean section under spinal anesthesia and were included in the study. Parturient to ASA physical status I-II scheduled for caesarean section were randomly selected for the study and are divided into group of 84 each.<strong></strong></p><p><strong>Results: </strong>There was significant difference in sensory block duration at T<sub>10</sub> (min) and total duration of analgesia (min) in both groups. This difference between two group’s was not significant. Adverse Effects in group RF 5 (5.9%) patients had hypotension and 2 (2.3%) bradycardias in group R 3 (3.5%) patient had hypotension.<strong></strong></p><p><strong>Conclusions: </strong>Hemodynamic parameters were comparable in both the groups. Total duration of analgesia and sensory block duration at T<sub>10</sub> was significantly shorter with ropivacaine (with saline) compared to ropivacaine with fentanyl.</p>

Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild‐to‐moderate acne vulgaris

2019 ◽  
Vol 19 (2) ◽  
pp. 393-399
Author(s):  
Surabhi Dayal ◽  
Kirti Dudeja Kalra ◽  
Priyadarshini Sahu
Keyword(s):  
Salicylic Acid ◽  
Comparative Study ◽  
Mandelic Acid ◽  
Acne Vulgaris ◽  
Efficacy And Safety ◽  
Acid Versus

Efficacy and safety of a novel water‐soluble herbal patch for acne vulgaris treatment: a randomized, assessor‐blinds controlled, intra‐individual split‐face comparative study

2021 ◽  
Author(s):  
Kulwipapat Jaturapisanukul ◽  
Montree Udompataikul ◽  
Silada kanolrungsee ◽  
Salinee Rojhirunsakool ◽  
Nanticha kamanamool ◽  
...  
Keyword(s):  
Comparative Study ◽  
Acne Vulgaris ◽  
Water Soluble ◽  
Efficacy And Safety ◽  
Split Face

Comparative study of buffered 50% glycolic acid (pH 3.0) + 0.5% salicylic acid solution vs Jessner's solution in patients with acne vulgaris

2017 ◽  
Vol 17 (5) ◽  
pp. 797-801
Author(s):  
Jeong In Jae ◽  
Hyun Dong Ju ◽  
Kim Dong Hyun ◽  
Moon Soo Yoon ◽  
Hee Jung Lee
Keyword(s):  
Salicylic Acid ◽  
Acid Solution ◽  
Comparative Study ◽  
Glycolic Acid ◽  
Acne Vulgaris ◽  
Acid Ph

scholarly journals Comparative clinical study of efficacy and safety of adapalene 0.1% gel versus benzoyl peroxide 2.5% gel for the treatment of acne vulgaris

2019 ◽  
Vol 8 (10) ◽  
pp. 2317
Author(s):  
Anuradha Dubey ◽  
Hanmant Amane
Keyword(s):  
Side Effects ◽  
Benzoyl Peroxide ◽  
Acne Vulgaris ◽  
Total Duration ◽  
The Other ◽  
Efficacy And Safety ◽  
Inflammatory Lesions ◽  
Significant Difference ◽  
Comparative Clinical Study ◽  
Topical Treatments

Background: Acne vulgaris is characterised by comedones, papules, pustules and nodules occurring in a sebaceous distribution. Topical treatments, such as adapalene and benzoyl peroxide, are popular in mild to moderate acne vulgaris. This study was aimed to compare the efficacy and safety of adapalene with benzoyl peroxide in the patients of mild to moderate acne vulgaris.Methods: We planned a randomized, open-labelled, prospective study to compare the efficacy and side effects of adapalene and benzoyl peroxide in acne patients. A total of 100 patients with mild to moderate acne vulgaris were included in the study. They were randomly divided into 2 groups with 50 patients in each group. One group was given 0.1% adapalene gel and the other group received 2.5% benzoyl peroxide gel. Efficacy was assessed as reduction in the lesion counts, whereas for safety, the side effects like dryness, burning, irritation, erythema were recorded during the treatment. Total duration of the study was 3 months.Results: The study revealed that adapalene was more effective than benzoyl peroxide in treating non-inflammatory and inflammatory lesions of acne vulgaris, and there was a statistically significant difference found between the groups (p≤0.05) in efficacy. Adapalene was also found to be comparatively safer than benzoyl peroxide because the patients treated with adapalene had lesser side effects than those treated with benzoyl peroxide.Conclusions: Our study concludes a better efficacy and safety of adapalene than benzoyl peroxide in the treatment of mild to moderate acne vulgaris.

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