Reduction in Serum High Mobility Group Box-1 Level by Polymyxin B-Immobilized Fiber Column in Patients with Idiopathic Pulmonary Fibrosis with Acute Exacerbation

2011 ◽  
Vol 32 (4) ◽  
pp. 310-316 ◽  
Author(s):  
Shinji Abe ◽  
Hiroki Hayashi ◽  
Yoshitsugu Seo ◽  
Kuniko Matsuda ◽  
Koichiro Kamio ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Acute Exacerbation ◽  
High Mobility ◽  
Polymyxin B ◽  
High Mobility Group

Serum high‐mobility group box 1 is associated with the onset and severity of acute exacerbation of idiopathic pulmonary fibrosis

Respirology ◽  
2019 ◽  
Vol 25 (3) ◽  
pp. 275-280 ◽  
Author(s):  
Kakuhiro Yamaguchi ◽  
Hiroshi Iwamoto ◽  
Shinjiro Sakamoto ◽  
Yasushi Horimasu ◽  
Takeshi Masuda ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Acute Exacerbation ◽  
High Mobility ◽  
High Mobility Group

scholarly journals Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Masahito Ebina ◽  
Hiroyuki Taniguchi ◽  
Taku Miyasho ◽  
Shingo Yamada ◽  
Naoko Shibata ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Acute Exacerbation ◽  
Late Phase ◽  
High Mobility ◽  
Alveolar Epithelial Cells ◽  
High Mobility Group ◽  
High Mobility Group Protein ◽  
Cytoplasmic Staining ◽  
Group Protein

The pathogenesis of acute exacerbation of idiopathic pulmonary fibrosis (IPF) remains to be elucidated. To evaluate the roles of inflammatory mediators in acute exacerbation, the concentrations of high mobility group protein B1 (HMGB1), a chief mediator of acute lung injury, and 18 inflammatory cytokines were measured in the bronchoalveolar lavage fluid, serially sampled from seven IPF patients after the onset of acute exacerbation. HMGB1 gradually increased in the alveolar fluid after the onset of acute exacerbation, in positive correlation with monocytes chemotactic protein-1 (MCP-1), a potent fibrogenic mediator. In the lung tissues of eight IPF patients autopsied after acute exacerbation, intense cytoplasmic staining for HMGB1 was observed in the alveolar epithelial cells in alveolar capillary augmented lesions, where the capillary endothelial cells remarkably reduced the expression of thrombomodulin, an intrinsic antagonist of HMGB1. These results suggest pathogenic roles for HMGB1 and MCP-1 in the late phase of acute exacerbation of IPF.

scholarly journals Beneficial Effect of Polymyxin B-immobilized Fiber Column (PMX) Hemoperfusion Treatment on Acute Exacerbation of Idiopathic Pulmonary Fibrosis

2006 ◽  
Vol 45 (18) ◽  
pp. 1033-1038 ◽  
Author(s):  
Yoshitsugu Seo ◽  
Shinji Abe ◽  
Misuzu Kurahara ◽  
Daisuke Okada ◽  
Yoshinobu Saito ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Beneficial Effect ◽  
Acute Exacerbation ◽  
Polymyxin B

scholarly journals Polymyxin B-immobilized Fiber Column (PMX) Treatment for Idiopathic Pulmonary Fibrosis with Acute Exacerbation: A Multicenter Retrospective Analysis

2012 ◽  
Vol 51 (12) ◽  
pp. 1487-1491 ◽  
Author(s):  
Shinji Abe ◽  
Arata Azuma ◽  
Hiroshi Mukae ◽  
Takashi Ogura ◽  
Hiroyuki Taniguchi ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Retrospective Analysis ◽  
Acute Exacerbation ◽  
Polymyxin B

scholarly journals Direct hemoperfusion with polymyxin B-immobilized fiber column in a patient with acute exacerbation of idiopathic pulmonary fibrosis

2020 ◽  
Vol 35 (4) ◽  
pp. 302-306
Author(s):  
Shin Young Kim ◽  
Jin Han Park ◽  
Hyo Jung Kim ◽  
Hang Jea Jang ◽  
Hyun Kuk Kim ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Acute Exacerbation ◽  
Polymyxin B ◽  
Direct Hemoperfusion
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