Unusual Intracytoplasmic Crystalline Inclusions in Chronic Myelomonocytic Leukemia with Double Minute Chromosomes and MYC Amplification: A Rare Case

2014 ◽  
Vol 132 (1) ◽  
pp. 68-72 ◽  
Author(s):  
Kanji Miyazaki ◽  
Kenshi Suzuki
Keyword(s):  
Rare Case ◽  
Chronic Myelomonocytic Leukemia ◽  
Crystalline Inclusions ◽  
Double Minute ◽  
Myelomonocytic Leukemia ◽  
Double Minute Chromosomes

scholarly journals FLT3 Amplification as Double Minute Chromosomes in a Patient with Chronic Myelomonocytic Leukemia

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Heyang Zhang ◽  
Xiaoxue Wang ◽  
Shibo Li ◽  
Xianfu Wang ◽  
Xianglan Lu ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Gene Amplification ◽  
Chronic Myelomonocytic Leukemia ◽  
Comparative Genomic ◽  
Myeloid Neoplasms ◽  
Double Minute ◽  
Myelomonocytic Leukemia ◽  
Double Minute Chromosomes

Double minute chromosomes (dmins) are a form of gene amplification presenting as small spherical paired chromatin bodies. Dmins are rare in hematologic malignancies and are generally associated with a poor prognosis. Some case reports identified MYC or MLL gene amplification performing as dmin in myeloid neoplasms. FLT3 (FMS-related tyrosine kinase 3) acts as an oncogene in myeloid neoplasms which is associated with several signal transduction pathways. Genomic amplification of FLT3 has not been reported in hematological disease. The current study attempts to demonstrate the existence of double minute chromosomes via FLT3 gene amplification in a patient diagnosed with chronic myelomonocytic leukemia (CMML). Routine G-banded karyotype, array-based comparative genomic hybridization, and fluorescence in situ hybridization analyses were used to characterize the cytogenetic abnormality in the patient’s bone marrow. FLT3 amplification as dmins in a patient with CMML was revealed. This case study reports a rare double minute chromosome via FLT3 amplification in CMML by using array-based comparative genomic hybridization and fluorescence in situ hybridization analyses. The study also proposed another possible mechanism of FLT3 genes in leukemogenesis.

Trisomy 6 and Double Minute Chromosomes in a Case of Chronic Myelomonocytic Leukemia

1998 ◽  
Vol 106 (2) ◽  
pp. 180-181 ◽  
Author(s):  
Constantina Sambani ◽  
Dimitris T.P. Trafalis ◽  
George Vessalas ◽  
George Politis ◽  
Platon Peristeris ◽  
...  
Keyword(s):  
Chronic Myelomonocytic Leukemia ◽  
Double Minute ◽  
Myelomonocytic Leukemia ◽  
Double Minute Chromosomes

Acute myelomonocytic leukemia with double minute chromosomes and a normal karyotype

1987 ◽  
Vol 25 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Junko H. Ohyashiki ◽  
Kazuma Ohyashiki ◽  
Kenneth B. Miller ◽  
Barry P. Cuiffo ◽  
Avery A. Sandberg
Keyword(s):  
Normal Karyotype ◽  
Double Minute ◽  
Acute Myelomonocytic Leukemia ◽  
Myelomonocytic Leukemia ◽  
Double Minute Chromosomes

scholarly journals A Rare Case of Paraneoplastic Aortitis Associated with Chronic Myelomonocytic Leukemia

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Sylwia Sasinowska ◽  
Pamela Traisak ◽  
Michael McCormack ◽  
Hala Eid
Keyword(s):  
Rare Case ◽  
Chronic Myelomonocytic Leukemia ◽  
Large Vessel ◽  
Primary Malignancy ◽  
Broad Term ◽  
Abnormal Chest ◽  
Common Causes ◽  
Systemic Glucocorticoids ◽  
Thoracic And Abdominal ◽  
Myelomonocytic Leukemia

Aortitis is a broad term describing inflammation of the aorta. The most common causes of aortitis are the large-vessel vasculitides giant cell arteritis and Takayasu arteritis. Other etiologies include aortitis associated with other autoimmune disorders, infectious causes, and paraneoplastic and idiopathic cases. We describe a rare case of a large-vessel arteritis occurring in association with chronic myelomonocytic leukemia (CMML). A 68-year-old female with recent diagnosis of CMML presented to our office for evaluation of abnormal chest computed tomography (CT) that showed inflammation surrounding the entirety of thoracic and abdominal aorta, consistent with aortitis. In the absence of other evident causes of large-vessel vasculitis, we attributed this finding to a paraneoplastic autoimmune phenomenon and started treatment with systemic glucocorticoids. This rare case emphasizes the need to recognize autoimmune complications in CMML and treat the inflammation along with the primary malignancy promptly.

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