Effect of Polymorphisms in the NADSYN1/DHCR7 Locus (rs12785878 and rs1790349) on Plasma 25-Hydroxyvitamin D Levels and Coronary Artery Disease Incidence

Abstract Background To investigate the causal association between serum 25-hydroxyvitamin D (25OHD), calcium (Ca), and parathyroid hormone (PTH) levels and the risk of coronary artery disease (CAD) in patients with diabetes using a Mendelian randomization approach. Methods Genetic signatures associated with serum 25OHD, Ca, and PTH levels were extracted from recently published genome-wide association study (GWAS), including 79,366, 39,400, 29,155 individuals, respectively. Genetic association estimates for CAD in patients with diabetes were obtained from a GWAS of 15,666 individuals with diabetes (3,968 CAD cases, 11,696 controls). The inverse-variance-weighted method was employed for the primary analysis, and other robust methods were applied for sensitivity analyses. Results Six, seven and five single nucleotide polymorphisms were identified as instrumental variables for serum 25OHD, Ca and PTH levels, respectively. There was no significant association between genetically predicted serum 25OHD levels and the risk of CAD in patients with diabetes (odds ratio (OR) = 1.04, 95% confidence interval (CI): 0.58 - 1.87, P = 0.888). Similarly, genetically predicted serum Ca (OR = 1.83, 95% CI: 0.62 – 5.35, P = 0.273) and PTH levels (OR = 1.27, 95% CI: 0.67 – 2.44, P = 0.464) were not significantly associated with the risk of CAD in patients with diabetes. These findings were robust in sensitivity analyses. Conclusions/interpretation Serum 25OHD, Ca and PTH levels may not be causally associated with the risk of CAD in patients with diabetes.

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Serum Bioavailable and Free 25-Hydroxyvitamin D Levels, but Not Its Total Level, Are Associated With the Risk of Mortality in Patients With Coronary Artery Disease

Circulation Research ◽

10.1161/circresaha.118.313558 ◽

2018 ◽

Vol 123 (8) ◽

pp. 996-1007 ◽

Cited By ~ 29

Author(s):

Chao Yu ◽

Hongliang Xue ◽

Liqing Wang ◽

Qian Chen ◽

Xuechen Chen ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Hydroxyvitamin D ◽

Total Level ◽

Risk Of Mortality ◽

25 Hydroxyvitamin D ◽

Artery Disease

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Letter by Choi and Kwak Regarding Article, “Serum Bioavailable and Free 25-Hydroxyvitamin D Levels, but Not Its Total Level, Are Associated With the Risk of Mortality in Patients With Coronary Artery Disease”

Circulation Research ◽

10.1161/circresaha.119.315631 ◽

2019 ◽

Vol 125 (10) ◽

Author(s):

Yoon-Hyeong Choi ◽

Jung Hyun Kwak

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Hydroxyvitamin D ◽

Total Level ◽

Risk Of Mortality ◽

25 Hydroxyvitamin D ◽

Artery Disease

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Impact of serum 25 hydroxyvitamin D deficiency on lipid biomarkers in established coronary artery disease

Turkish Journal of Biochemistry ◽

10.1515/tjb-2021-0148 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Shaheena Yassir ◽

Madan Gopal Ramarajan ◽

Seema Patil ◽

Shaheen B. Shaikh ◽

Yassir M. Abdulla ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Lipid Profile ◽

Negative Correlation ◽

Density Lipoprotein ◽

Significant Negative Correlation ◽

Lipid Biomarkers ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Artery Disease

Abstract Objectives Vitamin D deficiency (VDD) is associated with coronary artery disease (CAD) directly by augmenting atherosclerosis and indirectly through cardiovascular risk factors. The present study was aimed to find an association of 25 hydroxyvitamin D (25(OH)D) with lipid profile among established CAD. Methods A cross-sectional study was conducted among 73 patients of angiographically confirmed CAD aged between 35 and 55 years of both gender. Serum 25(OH)D and lipid profile were estimated by ELISA kit and Roche autoanalyzer respectively. Atherogenic index of plasma (AIP) and sdLDL (small dense low-density lipoprotein) were calculated using the accepted formula. Results The mean 25(OH)D level was 17.95 ± 13.51. Only 15% had sufficient 25(OH)D level. There was a significant negative correlation of 25(OH)D with TC/HDL (T.cholesterol/High-density lipoprotein) ratio (p=0.022). Multivariate logistic regression analysis showed no statistically significant impact of 25(OH)D with lipid biomarkers. Conclusions We found low 25(OH)D mean value among CAD and a significant negative correlation of 25(OH)D with TC/HDL. This study suggests VDD may affect primary lipid target resulting in unfavorable outcomes in CAD.

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The Impact of Serum 25-hydroxyvitamin D, Calcium, and Parathyroid Hormone Levels on the Risk of Coronary Artery Disease in Patients With Diabetes: A Mendelian Randomization Study

10.21203/rs.3.rs-97969/v1 ◽

2020 ◽

Author(s):

Songzan Chen ◽

Fangkun Yang ◽

Tian Xu ◽

Yao Wang ◽

Kaijie Zhang ◽

...

Keyword(s):

Coronary Artery Disease ◽

Parathyroid Hormone ◽

Coronary Artery ◽

Mendelian Randomization ◽

Causal Association ◽

Serum 25Ohd ◽

Hydroxyvitamin D ◽

Patients With Diabetes ◽

25 Hydroxyvitamin D ◽

Artery Disease

Abstract BackgroundTo investigate the causal association between serum 25-hydroxyvitamin D (25OHD), calcium (Ca), and parathyroid hormone (PTH) levels and the risk of coronary artery disease (CAD) in patients with diabetes using a Mendelian randomization approach.MethodsGenetic signatures associated with serum 25OHD, Ca, and PTH levels were extracted from recently published genome-wide association study (GWAS), including 79,366, 39,400, 29,155 individuals, respectively. Genetic association estimates for CAD in patients with diabetes were obtained from a GWAS of 15,666 individuals with diabetes (3,968 CAD cases, 11,696 controls). The inverse-variance-weighted method was employed for the primary analysis, and other robust methods were applied for sensitivity analyses.ResultsSix, seven and five single nucleotide polymorphisms were identified as instrumental variables for serum 25OHD, Ca and PTH levels, respectively. There was no significant association between genetically predicted serum 25OHD levels and the risk of CAD in patients with diabetes (odds ratio (OR) = 1.04, 95% confidence interval (CI): 0.58 - 1.87, P = 0.888). Similarly, genetically predicted serum Ca (OR = 1.83, 95% CI: 0.62 – 5.35, P = 0.273) and PTH levels (OR = 1.27, 95% CI: 0.67 – 2.44, P = 0.464) were not significantly associated with the risk of CAD in patients with diabetes. These findings were robust in sensitivity analyses.Conclusions/interpretationThis study found no evidence to support the causal association between serum 25OHD, Ca and PTH levels and the risk of CAD in patients with diabetes.

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