Ontogeny of Benzodiazepine Binding Sites in Fetal Rat Brain: An in vitro Autoradiographic Study

2015 ◽  
pp. 111-118
Author(s):  
J. G. Richards ◽  
M. Schlumpf ◽  
W. Lichtensteiger ◽  
H. M�hler
Keyword(s):  
Rat Brain ◽  
Binding Sites ◽  
Autoradiographic Study ◽  
Fetal Rat ◽  
Benzodiazepine Binding ◽  
Benzodiazepine Binding Sites ◽  
Fetal Rat Brain

Benzodiazepine binding sites: Localization and characterization in the limbic system of the rat brain

1986 ◽  
Vol 16 (5) ◽  
pp. 573-596 ◽  
Author(s):  
Dominique Marcel ◽  
Dinah Weissmann-Nanopoulos ◽  
Evelyne Mach ◽  
J.F. Pujol
Keyword(s):  
Rat Brain ◽  
Limbic System ◽  
Binding Sites ◽  
Benzodiazepine Binding ◽  
Benzodiazepine Binding Sites

An autoradiographical saturation kinetic study of the different benzodiazepine binding sites in rat brain by using [3H] flunitrazepam as a radioligand

1995 ◽  
Vol 50 (10) ◽  
pp. 1619-1625 ◽  
Author(s):  
Carlos Soria ◽  
Victoria Revilla ◽  
Maria Adoración Candelas ◽  
Pedro Calvo ◽  
Arsenio Fernández-López
Keyword(s):  
Kinetic Study ◽  
Rat Brain ◽  
Binding Sites ◽  
Saturation Kinetic ◽  
Benzodiazepine Binding ◽  
Benzodiazepine Binding Sites

?-Adrenergic Binding Sites in Fetal Rat Brain

1984 ◽  
Vol 43 (2) ◽  
pp. 578-581 ◽  
Author(s):  
A. Bruinink ◽  
W. Lichtensteiger
Keyword(s):  
Rat Brain ◽  
Binding Sites ◽  
Fetal Rat ◽  
Fetal Rat Brain

Interaction between human brain tumour biopsies and fetal rat brain tissue in vitro

1990 ◽  
Vol 81 (2) ◽  
pp. 130-140 ◽  
Author(s):  
O. Engebraaten ◽  
R. Bjerkvig ◽  
M. Lund-Johansen ◽  
K. Wester ◽  
P.-H. Pedersen ◽  
...  
Keyword(s):  
Human Brain ◽  
Rat Brain ◽  
Brain Tissue ◽  
Brain Tumour ◽  
Fetal Rat ◽  
Rat Brain Tissue ◽  
Fetal Rat Brain

scholarly journals TGF-β1 EXPRESSION BY GLIOMA C6 CELLS IN VITRO

2017 ◽  
Vol 39 (4) ◽  
pp. 258-263 ◽  
Author(s):  
L D Liubich ◽  
L M Kovalevska ◽  
M I Lisyany ◽  
V M Semenova ◽  
T A Malysheva ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Rat Brain ◽  
Glioma Cells ◽  
C6 Glioma ◽  
C6 Glioma Cells ◽  
C6 Cells ◽  
Fetal Rat ◽  
Tgf Β1 ◽  
Fetal Rat Brain

The aim of the work was to study the impact of fetal rat brain cell supernatant (FRBCS) on the expression of transforming growth factor β1 (TGF-β1) and p53 in C6 cells of rat glioma in vitro. Materials and Methods: FRBCS was obtained from suspensions of fetal rat brain cells on the 14th (E14) day of gestation. C6 glioma cells were cultured for 48 h in the presence of FRBCS or FRBCS + anti-TGF-β1 monoclonal antibody. Immunocytochemical staining for TGF-β1 and p53 was performed. Results: The proportion of TGF-β1-immunopositive tumor cells in C6 glioma cultures was statistically significantly higher than in the control cell cultures of normal fetal rat brain. FRBCS reduced the proportion of TGF-β1-immunopositive tumor cells and increased the proportion of p53-immunopositive cells in C6 glioma cultures. In cells cultured with FRBCS + anti-TGF-β1 monoclonal antibody, the above effects of FRBCS were abrogated. Conclusion: The obtained results suggest that TGF-β1 seems to be responsible for decrease in TGF-β1 expression and increase in p53 expression in C6 glioma cells treated with FRBCS.

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