Chronic administration of diazepam to rats causes changes in EEG patterns and in coupling between GABA receptors and benzodiazepine binding sites in vitro

1984 ◽  
Vol 323 (1) ◽  
pp. 93-102 ◽  
Author(s):  
Laura Mele ◽  
Stefano Sagratella ◽  
Marino Massotti
Keyword(s):  
Binding Sites ◽  
Gaba Receptors ◽  
Chronic Administration ◽  
Benzodiazepine Binding ◽  
Benzodiazepine Binding Sites

Anticonvulsant and anxiolytic-like effects of compounds isolated from Polygala sabulosa (Polygalaceae) in rodents: in vitro and in vivo interactions with benzodiazepine binding sites

2007 ◽  
Vol 197 (3) ◽  
pp. 351-360 ◽  
Author(s):  
Filipe Silveira Duarte ◽  
Mariel Marder ◽  
Alexandre Ademar Hoeller ◽  
Marcelo Duzzioni ◽  
Beatriz Garcia Mendes ◽  
...  
Keyword(s):  
Binding Sites ◽  
Benzodiazepine Binding ◽  
Benzodiazepine Binding Sites

scholarly journals The interaction of substituted benzamides with brain benzodiazepine binding sites in vitro

1988 ◽  
Vol 94 (4) ◽  
pp. 1234-1240 ◽  
Author(s):  
Roger W. Horton ◽  
Sandra Lowther ◽  
Jane Chivers ◽  
Peter Jenner ◽  
C. David Marsden ◽  
...  
Keyword(s):  
Binding Sites ◽  
Benzodiazepine Binding ◽  
Substituted Benzamides ◽  
Benzodiazepine Binding Sites

Increased density of peripheral benzodiazepine-binding sites in ovarian carcinomas as compared with benign ovarian tumours and normal ovaries

1990 ◽  
Vol 78 (2) ◽  
pp. 155-158 ◽  
Author(s):  
Yeshayahu Katz ◽  
Gilad Ben-Baruch ◽  
Yoel Kloog ◽  
Joseph Menczer ◽  
Moshe Gavish
Keyword(s):  
Ovarian Carcinoma ◽  
Binding Sites ◽  
Ovarian Carcinomas ◽  
Binding Characteristics ◽  
Normal Tissues ◽  
Benign Ovarian Tumours ◽  
Benzodiazepine Binding ◽  
Ovarian Tumours ◽  
Benzodiazepine Binding Sites

1. Benzodiazepines are involved in the control of proliferation and differentiation of normal and malignant cells in vitro. This regulatory ability is probably mediated via peripheral benzodiazepine-binding sites. 2. In the present study we compared the binding characteristics of peripheral benzodiazepine-binding sites in human epithelial ovarian carcinoma with those in benign ovarian tumours and normal ovaries. 3. The affinity and density of peripheral benzodiazepine-binding sites in homogenate preparations of ovarian carcinoma as compared with benign ovarian tumours and with normal tissues (used as controls) were determined using a ligand specific for peripheral benzodiazepine-binding sites, [3H]PK 11195, an isoquinoline carboxamide derivative. 4. We observed a robust (three-to five-fold) increase in the neoplasm compared with benign ovarian tumours and normal tissues, without a concomitant change in affinity values. 5. This finding may reflect a change in the metabolic rates of ovarian cancer which is expressed as the alteration in the density of peripheral benzodiazepine-binding sites.

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